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Mineo Kondo, Yozo Miyake, Nagako Kondo, Atsuhiro Tanikawa, Satoshi Suzuki, Masayuki Horiguchi, Hiroko Terasaki; Multifocal ERG Findings in Complete Type Congenital Stationary Night Blindness. Invest. Ophthalmol. Vis. Sci. 2001;42(6):1342-1348.
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purpose. To study the multifocal electroretinogram (mfERG) in patients with the
complete type of congenital stationary night blindness (cCSNB), which
is thought to be due to a defect in neurotransmission from the
photoreceptors to the ON-bipolar cells.
methods. mfERGs were recorded with the VERIS recording system from four patients
with cCSNB, none of whom had nystagmus. The stimulus array consisted of
61 hexagons, and the total recording time was approximately 4 minutes.
The amplitudes and implicit times of the first- and second-order
kernels of the local responses were compared with those from 20 myopic
controls. Waveforms of the summed response from all locations were also
compared between the two groups.
results. The first-order kernels of the mfERGs of cCSNB patients had normal
amplitudes but delayed implicit times for nearly the whole field
tested. The second-order kernel was severely attenuated in amplitude in
cCSNB patients. The ratios of the second- to first-order kernel
amplitudes were significantly reduced in cCSNB and clearly separated
the cCSNB group from the control group without any overlap of the
conclusions. The second-order kernel, which is involved in adaptative mechanism of
the retina to repeated flashes, is selectively reduced in cCSNB. The
delay of the implicit times of the first-order kernel in patients with
cCSNB may be related to the severe amplitude reduction of the
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