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Michael A. Sandberg, Basil S. Pawlyk, Eliot L. Berson; Acuity Recovery and Cone Pigment Regeneration after a Bleach in Patients with Retinitis Pigmentosa and Rhodopsin Mutations. Invest. Ophthalmol. Vis. Sci. 1999;40(10):2457-2461.
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purpose. To assess visual acuity recovery times and cone photopigment regeneration
kinetics after a bleach in the fovea of patients with dominant
retinitis pigmentosa due to rhodopsin mutations.
methods. The authors measured acuity recovery times by computerized
photostress testing in 13 patients with dominant retinitis pigmentosa
and one of eight rhodopsin mutations. The authors also measured their
time constants of cone photopigment regeneration with a video imaging
fundus reflectometer to determine whether acuity recovery time depended
on pigment regeneration kinetics. These values were compared with those
of normal subjects, by the Mann–Whitney U test. The
relationship between acuity recovery time and the time constant of cone
photopigment regeneration among the patients was quantified by the
Spearman rank correlation.
results. The visual acuity recovery times, which averaged 22.0 seconds for
the patients with retinitis pigmentosa and 11.2 seconds for the normal
subjects, were significantly slower for the patient group
(P < 0.001). The time constants of cone pigment
regeneration, which averaged 172 seconds for the patients with
retinitis pigmentosa and 118 seconds for the normal subjects, also were
significantly slower for the patient group (P =
0.043). The authors also found a significant, positive correlation
between the visual acuity recovery time and the time constant of
pigment regeneration for the patients with retinitis pigmentosa
(r = 0.65, P = 0.017).
conclusions. A slowing of foveal visual acuity recovery and cone pigment
regeneration, which are related to each other, can occur in patients
with retinitis pigmentosa, due to a rod-specific gene
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