Purchase this article with an account.
Donald C. Hood, Jeffrey G. Odel, Xian Zhang; Tracking the Recovery of Local Optic Nerve Function after Optic Neuritis: A Multifocal VEP Study. Invest. Ophthalmol. Vis. Sci. 2000;41(12):4032-4038.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
purpose. To explore the multifocal visual evoked potential (mVEP) as a technique
for tracking local optic nerve damage after unilateral optic neuritis
methods. Humphrey visual fields and mVEP recordings were obtained from three
patients within 7 days of an episode of ON. Patients were retested
during the recovery phase, approximately 4 to 7 weeks later. The
multi-input procedure of Sutter was used to obtain 60 local VEP
responses (the mVEP) to a scaled checkerboard pattern. The mVEPs were
recorded separately for monocular stimulation of both eyes.
results. Initially, all three patients had extensive visual field defects,
reduced visual acuity, and depressed mVEP amplitude in regions of poor
visual field sensitivity. By 4 to 7 weeks, the fields recovered to near
normal sensitivity in most locations, and visual acuity returned to
20/20. The mVEP recovered to nearly full amplitude in all regions, but
substantial delays were present in many locations. The delayed
responses were associated with regions of visual field loss documented
during the acute phase.
conclusions. The mVEP can be used to track local optic nerve damage after unilateral
ON. This technique should be useful in observing the effects of
treatments as well as in testing hypotheses about the mechanisms
underlying both the acute loss of vision and the subsequent
This PDF is available to Subscribers Only