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Minoru Endo, Jon H. Kaas, Neeragi Jain, Earl L. Smith, Yuzo Chino; Binocular Cross-Orientation Suppression in the Primary Visual Cortex (V1) of Infant Rhesus Monkeys. Invest. Ophthalmol. Vis. Sci. 2000;41(12):4022-4031.
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© ARVO (1962-2015); The Authors (2016-present)
purpose. To better understand the course of cortical maturation during early
development, the phenomenon of binocular cross-orientation suppression
in neurons of the primary visual cortex (V1) in young infant monkeys
methods. Extracellular single-unit recordings were made in anesthetized and
paralyzed monkeys ranging in age between 6 days and 8 weeks.
Orthogonally oriented, dichoptic sine-wave gratings were used as visual
results. V1 neurons in young infant monkeys showed a higher prevalence and
greater magnitude of binocular cross-orientation suppression than in
adult monkeys. Binocular suppression decreased and reached an adult
level between 4 and 8 weeks of age, the presumed onset-age for
stereopsis in monkeys.
conclusions. During the first 4 weeks of life, the functional connections that are
necessary for initiating binocular cross-orientation suppression exist
in the monkey primary visual cortex. This finding is consistent with
the view that before the abrupt onset of stereopsis, human infants may
detect the differences between interocularly iso-oriented gratings and
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