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Frank Schuettauf, Rita Naskar, Christian K. Vorwerk, David Zurakowski, Evan B. Dreyer; Ganglion Cell Loss after Optic Nerve Crush Mediated through AMPA-Kainate and NMDA Receptors. Invest. Ophthalmol. Vis. Sci. 2000;41(13):4313-4316.
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purpose. Glutamate antagonists can block ganglion cell death due to optic nerve
crush. Although most investigators have focused on blockade of the N-methyl-d-aspartate (NMDA) subtype of
glutamate receptor, we have chosen to evaluate the efficacy of blockade
of the AMPA-kainate (KA) receptor in this experimental paradigm.
methods. The optic nerves of rats were crushed, and ganglion cell survival was
assessed. Groups of animals were treated with an NMDA antagonist, an
AMPA-KA antagonist, or both.
results. The AMPA-KA antagonist DNQX was more effective, although not additive
in preserving retinal ganglion cells after optic nerve crush than the
NMDA antagonist MK801.
conclusions. Activation of the AMPA-KA subtype of glutamate receptor may play a role
in glutamate-mediated cell death after optic nerve
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