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Atsushi Hayashi, Shinichi Usui, Kiyotomi Kawaguchi, Sayuri Fujioka, Shunji Kusaka, Takashi Fujikado, Masahito Ohji, Yasuo Tano; Retinal Changes after Retinal Translocation Surgery with Scleral Imbrication in Dog Eyes. Invest. Ophthalmol. Vis. Sci. 2000;41(13):4288-4292.
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purpose. To examine retinal changes induced by scleral imbrication during
retinal translocation surgery in dog eyes.
methods. Fifteen dogs were anesthetized and underwent retinal translocation
surgery. After lensectomy and vitrectomy, an intentional retinal
detachment was created, and the upper temporal sclera around the
equator was imbricated with five mattress sutures. Translocated
distances were calculated by pre- and postoperative photographs. At 1,
2, and 4 weeks after the surgery, the retina was studied by TdT-dNTP
terminal nick-end labeling (TUNEL) and immunohistochemistry of peanut
agglutinin (PNA) lectin and glial fibrillary acidic protein (GFAP).
results. The retina was translocated by a mean distance of 0.53 ± 0.30
disc diameters or 959 ± 543 μm. Retinal folds were created
around the optic disc in all eyes. Histologic examination of the
retinal folds 1 week after the surgery showed many TUNEL-positive cells
in the outer nuclear layer, loss of photoreceptor cells, and shortening
of the outer and inner segments. A strong immunoreactivity to GFAP was
detected in the folds of the retina.
conclusions. The results demonstrated that retinal translocation surgery by scleral
imbrication inevitably caused retinal folds as a postoperative
complication, and the retina within the folds showed extensive loss of
photoreceptor cells. It is recommended that the foveal translocation
surgery be planned to avoid involving the fovea in the retinal
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