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Geoffrey B. Arden, Janet E. Wolf; The Electro-oculographic Responses to Alcohol and Light in a Series of Patients with Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2000;41(9):2730-2734.
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purpose. Alcohol produces changes in the electro-oculogram (EOG) similar to
those caused by light, but indirect evidence indicates that alcohol
directly affects the retinal pigment epithelium (RPE). An investigation
of the alcohol-induced increase (termed the alcohol rise in this study)
in patients with disease of the photoreceptors was therefore of
methods. Standard EOGs were recorded after oral administration of alcohol in a
group of patients with retinitis pigmentosa (RP).
results. The average response of 17 patients to alcohol was a slow decrease of
potential, which contrasts with the normal alcohol rise. In patients
with considerable residual peripheral field, alcohol produced a small
increase of voltage, followed by a prolonged decrease. The slower
decrease in the EOG voltage was evident in patients with small fields
and could be seen even in those who had lost all visual function. Light
caused small increments of EOG voltage (termed light rises), again
related to the field size.
conclusions. It is probable that the intracellular signaling system that causes the
alcohol and light rises is lost in RP.
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