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Marc Labetoulle, Paul Kucera, Gabriella Ugolini, Florence Lafay, Eric Frau, Hervé Offret, Anne Flamand; Neuronal Propagation of HSV1 from the Oral Mucosa to the Eye. Invest. Ophthalmol. Vis. Sci. 2000;41(9):2600-2606.
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purpose. To identify possible neuronal pathways leading to herpetic ocular
disease after primary oral infection in mice.
methods. The SC16 strain of herpes simplex virus (HSV)-1 (106 plaque-forming units) was injected into the mucocutaneous border of the
left upper lip. Animals were killed 2 to 10 days postinoculation (DPI).
Spread of the virus in neural structures was studied by
results. HSV1 first replicated at the site of inoculation and then at the
superior cervical ganglion (at 2 DPI). The trigeminal ganglion and the
facial nerve fibers were infected by 4 DPI. Infection of the ciliary
body and iris occurred at 6 DPI, together with several brain stem
nuclei belonging to the autonomic or sensory pathways. Between 8 and 10
DPI, the neural infection gradually cleared up, except for the
ipsilateral sympathetic ganglion, and ipsilateral keratitis appeared in
conclusions. The pattern of viral dissemination in this mouse model suggests that
infection of iris and ciliary body results from transfer of virus in
the superior cervical ganglion from sympathetic neurons innervating the
lip to neighboring neurons innervating the anterior uvea. Later,
zosteriform spread of virus from the trigeminal system may have
contributed to the clinical and histologic
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