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Naoya Fujimoto, Emiko Adachi-Usami; Frequency Doubling Perimetry in Resolved Optic Neuritis. Invest. Ophthalmol. Vis. Sci. 2000;41(9):2558-2560.
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purpose. To study the visual field with frequency doubling technology (FDT) in
patients with recovered optic neuritis and to detect loss of
magnocellular projecting cells (M cells) in the extrafovea.
methods. Fourteen patients who had undergone one attack of optic neuritis and
recovered normal vision (1.0 or better) and critical fusion frequency
were examined with conventional Humphrey automated perimetry central
30-2 and FDT c-20 threshold tests. After 1 year, 12 patients were
reexamined with central 30-2 and FDT c-20 tests. The visual fields
examined by both perimeters were divided into three zones. The mean
sensitivity in each zone in involved eyes, uninvolved eyes, and
involved eyes after 1 year was compared with that in healthy eyes.
results. Conventional automated perimetry showed depression toward the fovea.
However, FDT demonstrated general depression, especially midperipheral
deficits. After 1 year, the midperipheral deficits with frequency
doubling perimetry (FDP) improved, as did central depression,
as observed with central 30-2 tests.
conclusions. FDT was developed to detect early glaucomatous damage, which was
thought to be caused by a loss of M cells. Our study suggested that
patients with resolved optic neuritis also had a loss of M-cell
function in the extrafoveal area, as observed by field damage and its
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