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José L. Hernández-Verdejo, Miguel A. Teus, José M. Román, Gema Bolívar; Porcine Model to Compare Real-Time Intraocular Pressure during LASIK with a Mechanical Microkeratome and Femtosecond Laser. Invest. Ophthalmol. Vis. Sci. 2007;48(1):68-72. doi: 10.1167/iovs.06-0192.
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purpose. To compare real-time intraocular pressure (IOP) during laser in situ keratomileusis (LASIK) in porcine eyes using two types of microkeratomes.
methods. An interventional, prospective study of two microkeratomes: a Moria 2 (Moria group) and an IntraLase femtosecond laser (IntraLase Corp., Irvine, CA; IntraLase group). These devices were used to create lamellar corneal flaps in freshly enucleated porcine eyes. The IOP changes induced by the procedures were recorded with a reusable blood pressure transducer connected to the anterior chamber by direct cannulation.
results. Seven porcine eyes were studied in each group. The IOP increased during the suctioning phase, reaching a mean of 122.52 ± 30.40 and 160.52 ± 22.73 mm Hg during the cutting phase in the Moria group (the total time in this group was 36.42 ± 7.48 seconds; suctioning required 21.42 ± 7.48 seconds and the cutting phase, 15 ± 2.88 seconds). In the IntraLase group, the IOP reached 89.24 ± 24.26 mm Hg during the suctioning phase and 119.33 ± 15.88 mm Hg during the intrastromal laser application (the total time was 92.85 ± 13.49 seconds; suctioning required 40.00 ± 9.57 seconds and the cutting phase 52.85 ± 5.66 seconds). Both IOPs during both phases differed significantly between the two groups (P = 0.01 for all comparisons).
conclusions. Real-time IOP can be measured during LASIK using a transducer connected to the anterior chamber. The results showed a significant increase in IOP during the procedure in both groups, although with the IntraLase the IOP seemed to increase to a lesser extent than with the conventional mechanical microkeratome.
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