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Peter Jeppesen, Javad Sanye-Hajari, Toke Bek; Increased Blood Pressure Induces a Diameter Response of Retinal Arterioles that Increases with Decreasing Arteriolar Diameter. Invest. Ophthalmol. Vis. Sci. 2007;48(1):328-331. doi: https://doi.org/10.1167/iovs.06-0360.
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purpose. To study the diameter response of retinal arterioles as a function of the arteriolar diameter.
methods. Ten healthy young volunteers aged 22 to 33 years were subjected to diameter measurement of four successive segments of a retinal arteriole with a retinal vessel analyzer (RVA). At each of the segments, the diameter response during an increase in the systemic blood pressure (mean arterial pressure [MAP]) induced by isometric exercise was compared to the diameter of the arterioles during rest.
results. The isometric exercise induced a significant contraction of the studied vessel segments averaging 2.5% ± 0.4% (P < 0.0001, n = 40). There was a significant negative correlation between the baseline diameter of the studied vessel segments and the diameter response induced by isometric exercise (P = 0.02).
conclusions. The blood pressure–induced diameter response of retinal arterioles increased with decreasing diameter of the vessels. The results indicate that the distal retinal arterioles play a major role in the regulation of retinal blood flow.
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