Erratum

Erratum

Erratum in: “A New Locus for Autosomal Dominant Cataract on Chromosome 19: Linkage Analyses and Screening of Candidate Genes” by Bateman et al. ( Invest Ophthalmol Vis Sci. 2006;47:3441–3449). 

In the Abstract, the 4th sentence of the Results section should read, “Assuming full penetrance, the highest calculated maximum lod score was 3.91 with D19S903.” 

In Figure 1 , haplotype shading was incorrect for generation 3, individual 5, allele 8. 

In Table 1 , there are corrections to four lod scores in the Crystallin, alpha A and Crystallin beta B2 lines: Crystallin, alpha A: the lod score at θ = 0.3 should be −0.09. Crystallin, beta B2: the lod score at θ = 0.05 should be −5.25, the lod score at θ = 0.1 should be −2.47, and the lod score at θ = 0.3 should be −0.52. 

Figure 1.

 

Pedigree of ADC4 family with haplotypes in the mapped region of chromosome 19. The pedigree has been modified slightly, to protect the confidentiality of the family. Affected individuals are annotated as solid symbols; numbers indicate individuals studied (examined, samples obtained). Haplotypes in the critical region on chromosome 19 are indicated below each individual studied for linkage in this region, and the conserved region is in a shaded box. *Individuals from whom DNA was collected.

Table 1.

 

ADC Panel Markers and Lod Scores with ADC4 Locus

Gene; Protein	Mbp, †	Gene/Phenotpe Symbols (OMIM)	Marker			Allele Size Range (bp)	PCR Conditions	Lod Score
								Locus	Mbp			(θm = θf = 0)	0.001	0.05	0.1	0.2	0.3	0.4
		CCV	D1S243	2.2	142-170	1998 Panel	−∞	−8.78	−2.18	−1.17	−0.39	−0.12	−0.03
		CTPA	D1S508	7.5	73-85	1998 Panel	−∞	−8.60	−3.22	−2.18	−1.15	−0.58	−0.23
Gap junction protein alpha 8; connexin 50	144.6	CZP1/GJA8	D1S514	120.0	145-157	1998 Panel	−∞	−1.50	0.12	0.32	0.42	0.36	0.22
		Nuclear cataracts	D2S2333	85.4	246-260	TA	−∞	−14.39	−4.35	−2.70	−1.23	−0.54	−0.17
Crystallin, gamma C, gamma D	208.8	CRYG	D2S72	204.6	159-173	1998 Panel	−∞	−14.39	−4.33	−2.66	−1.16	−0.45	−0.11
Beaded filament structural protein 2	133.3	BFSP2	D3S1267	124.5	129-167	TA	−∞	−12.29	−3.89	−2.47	−1.17	−0.52	−0.17
Paired-like homeodomain transcription factor 3	104.0	PITX3	D10S2470	N/A	243-267	TA	−∞	−2.99	0.21	0.60	0.74	0.58	0.30
Paired box gene 6	31.8	PAX6	PAX6CA/GT	31.8	272-292	TA	−∞	−17.69	−5.91	−3.91	−2.04	−1.05	−0.42
Crystallin, alpha B	111.3	CRYAB	D11S4176	93.7	224-254	TA	−∞	−14.69	−4.61	−2.92	−1.37	−0.60	−0.19
Major intrinsic protein of lens fiber	55.1	MIP	D12S90	56.7	166-182	1998 Panel	−∞	−2.39	0.77	1.11	1.17	0.94	0.54
Gap junction protein alpha 3; connexin 46	19.6	CZP3/GJA3	D13S1236	21.6	124-132	1998 Panel	−∞	−2.70	−1.00	−0.70	−0.40	−0.22	−0.10
		CCPSO	D15S117	56.3	132-150	1998 Panel	−∞	−14.39	−4.35	−2.70	−1.23	−0.54	−0.17
		CTM	D16S265	62.1	89-117	1998 Panel	−∞	−11.69	−3.35	−2.00	−0.84	−0.31	−0.07
Heat-shock transcription factor 4	65.8	HSF4	D16S3095	68.5	150-162	TA	−∞	−4.20	−0.90	−0.42	−0.05	0.06	0.06
		CTM	D16S518	76.7	272-290	1998 Panel	−∞	−11.39	−3.05	−1.71	−0.56	−0.09	0.07
		CTAA2	D17S849	0.4	251-261	1998 Panel	−∞	−11.99	−3.63	−2.26	−1.06	−0.52	−0.23
Crystallin, beta A1	24.6	CCZS	D17S805	19.3	216-228	1998 Panel	−∞	−11.69	−3.35	−2.00	−0.84	−0.31	−0.07
		CCA1	D17S836	74.8	202-210	1998 Panel	0.30	0.30	0.26	0.21	0.13	0.06	0.02
Ferritin	54.2	FTL	D19S412	51.7	97-109	TA	*
		CCP3	D20S917	9.2	141-167	TA	*
Crystallin, alpha A	43.5	CRYAA	D21S171	44.8	111-133	1998 Panel	−∞	−4.50	−1.18	−0.67	−0.25	−0.09	−0.02
Crystallin, beta B2	23.9	CRYBB2	D22S258	24.3	177-195	1998 Panel	−∞	−12.29	−5.25	−2.47	−1.17	−0.52	−0.17
Crystallin, beta B1	25.3	CRYBB1	D22S1167	25.4	266-278	TA		−8.10	−3.00	−2.10	−1.19	−0.67	−0.29

 TA, true allele PCR conditions (Applied Biosystems, Inc.).

*  Markers added to panel after ADC4 linkage analyses concluded.

†  Mb locations based on NCBI map build 35.1.