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Beatrix Feigl, Ian B. Stewart, Brian Brown, Andrew J. Zele; Local Neuroretinal Function during Acute Hypoxia in Healthy Older People. Invest. Ophthalmol. Vis. Sci. 2008;49(2):807-813. doi: 10.1167/iovs.07-0994.
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purpose. To measure the effect of acute, mild, systemic hypoxia on neuroretinal function in two different age groups.
methods. The slow-flash paradigm of the multifocal electroretinogram (mfERG) was measured in two different oxygenation levels. Twelve participants of two age groups (28 ± 4 and 55 ± 5 years) breathed room air (normoxia) or 12% oxygen (hypoxia).
results. During normoxia (SaO2 = 98%) there was a significantly different effect between the younger and older participants on the mfERG positive waveform components (N1P1 amplitudes and P1 implicit times; P < 0.001). Hypoxia (SaO2 = 90%) significantly decreased N1P1 response density amplitudes in the central retinal field in both groups, with a larger effect in the older group (P < 0.001). There was no significant change in function of the cellular generators of oscillatory potentials (OPs).
conclusion. The results extend recent findings by showing a greater effect of hypoxia on ON- and OFF-bipolar cell function in healthy older persons than in younger persons, but no effect on OPs during moderate acute hypoxia in either age group.
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