New Zealand White female rabbits (weight range, 2.5–3.5 kg) from the Western Oregon Rabbit Company (Philomath, OR) were anesthetized by inhalation of 2% to 4% isoflurane. Pupils were dilated with 1% tropicamide and 2.5% phenylephrine hydrochloride, and 0.5% proparacaine drops was administered to each eye. A surgical microscope (model 310187; Zeiss, Jena, Germany) was used with a silicone flat lens (Dutch Ophthalmics, Kingston, NH) to visualize the retina. After disinfection with 5% povidone iodine, 100 μL autologous blood obtained through the ear vein was immediately injected into the subretinal space in a nasal juxtapapillary location along the myelinated streak. An angled 1-inch, 30-gauge needle (Becton Dickinson, Franklin Lakes, NJ) was introduced transsclerally 3 to 4 mm posterior to the limbus, and blood was injected subretinally to form a bullous retinal elevation. In other eyes, blood injection was made under the retinal pigment epithelium (RPE). This resulted in a low, diffuse hemorrhage, confirmed histologically to be in the sub-RPE space, allowing comparison with the effects of blood in the subneurosensory retinal space. In selected fellow eyes, 2 mg triamcinolone acetonide (IVTA; Bristol-Myers Squibb, Princeton, NJ) was injected intravitreally immediately after the bilateral subretinal blood injection. Subconjunctival antibiotic (cefazolin, 150 μL) was given after the procedure.