December 2008
Volume 49, Issue 12
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Index  |   December 2008
2008 Subject Index
Investigative Ophthalmology & Visual Science December 2008, Vol.49, 5674-5706. doi:https://doi.org/
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      2008 Subject Index. Invest. Ophthalmol. Vis. Sci. 2008;49(12):5674-5706. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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January pages 1–478 
February pages 479–842 
March pages 843–1290 
April pages 1291–1744 
May pages 1745–2302 
June pages 2303–2780 
July pages 2781–3258 
August pages 3259–3740 
September pages 3741–4218 
October pages 4219–4696 
November pages 4697–5174 
December pages 5175–5706 
A
ABCA4 gene, retinal dysfunction in patients with Stargardt disease and carrier relatives, 1191 
ABCR-deficient mice 
lipofuscin pigments in RPE after vitamin A supplementation, 3821 
recovery of rod photoreceptors in, 2743 
Acanthamoeba-induced cytopathic effect, inhibition by milk proteins, 1010 
Accommodation 
age-related changes in, 1736 
ciliary body forward accommodative movement facilitated by zonular attachments to lens capsule (monkey), 5495 
effect of surgical intervention on lens and ciliary body function in monkeys, 5484 
lens refractive index distribution changes with age and, 2531 
objective accommodative amplitudes by age, 2919 
Acvr1, role in lens development (mouse), 4953 
Acyl-CoA dehydrogenase 9 and carnitine palmitoyltransferase I in retina, 1660 
Adenosine receptors 
mediation of cannabidiol anti-inflammation in retina by equilibrative nucleoside transporter and A2A adenosine receptor (rat), 5526 
NMDA relaxation of porcine retinal arterioles via, 4590 
Adherent junctions expressed by corneal endothelial cells, 3879 
Adhesion molecules, poly(I:C) in immunoinflammatory response in cultured corneal fibroblasts, 3336 
Adolescents, OCT study of retinal and optic disc findings in, 4328 
α2-Adrenergic receptor subtypes and diurnal IOP variation (mouse), 929 
β2-Adrenergic receptor signaling–mediated corneal epithelial wound repair (mouse), 1857 
Advanced glycation end products, inhibition of crystallin ascorbylation in mouse model of lenticular aging, 4945 
Age effects. See also Geriatric population; Pediatric population 
age-dependent control of lens growth by hypoxia, 1023 
age-related changes in accommodation, 1736 
age-related changes in rat corneal epithelial nerve density, 910 
age-related changes in retinal functional topography, 5024 
age-related cone abnormalities in zebrafish with genetic lesions in sonic hedgehog, 4631 
age-related losses of RGCs and axons, 4437 
effect of age and fixation instability on retinotopic mapping of primary visual cortex, 3734 
effect of aging on retinal artery blood column diameter, 2094 
fiber cell beaded filament and lens structural stability (mouse), 1030 
HIF-1 as age-dependent regulator of lens cell proliferation (mouse), 4961 
inhibition of crystallin ascorbylation in mouse model of lenticular aging, 4945 
lens refractive index distribution changes with age and accommodation, 2531 
lipoprotein-like particle accumulation in aging Bruch’s membrane, 2721 
local neuroretinal function during acute hypoxia in older people, 807 
objective accommodative amplitudes by age, 2919 
on torsional optokinetic nystagmus, 589 
on transscleral albumin permeability, 4041 
Age-Related Eye Disease Study 2, brightness, contrast, and color balance of digital vs. film retinal images in, 3269 
Age-related macular degeneration (AMD) 
AMD-like lesions in rat retina after perinatal hemorrhage, 2790 
brightness, contrast, and color balance of digital vs. film retinal images in, 3269 
cataract surgery and risk of, 4795 
CCL2, CCR2, and TLR4 genes in, 364 
ceruloplasmin/hephaestin knockout mouse model of, 2728 
comparison of bevacizumab, ranibizumab, and pegaptanib in vitro, 4523 
complement factor H (CFH) polymorphism in 
in Chinese patients, 3312 
functional and structural implications of, 1763 
HTRA1 variants, smoking and, 2357 
measurement in plasma using monoclonal antibodies, 1983 
neovascular AMD in Koreans, 2071 
10q26 gene cluster variants and AMD risk in Indian patients and, 1771 
documenting fixation at an extrafoveal locus in, 5274 
elastin-mediated choroidal endothelial cell migration in, 5574 
fMRI study of eye movement control in, 1728 
focal macular ERG in wet-type AMD, 3121 
foveal cone–photoreceptor integrity in, 2077 
genotype–phenotype correlations for exudative AMD, 3090 
high-resolution spectral domain OCT in geographic atrophy associated with, 4137 
HLA-Cw*0701 genotype and NK cell receptor AA haplotype in, 5077 
imaging polarimetry in, 2661 
interleukin gene polymorphisms in, 693 
late outgrowth endothelial progenitor cells in, 2696 
lutein/zeaxanthin and omega-3 fatty acid supplementation in older adults, 3864 
macular pigment and AMD (new developments), 843 
mitochondrial proteomics of RPE in, 2848 
neovascular 
choroidal circulation and, 358 
coagulation gene predictors of PDT for, 3100 
and complement factor H polymorphism in Koreans, 2071 
elastin gene polymorphisms in polypoidal choroidal vasculopathy and, 1101 
OCT repeatability in, 1084 
phacoemulsification and, 1079 
quantitative OCT after ranibizumab for, 3115 
quantitative OCT findings in subtypes of, 5048 
in vivo 3-D optical frequency domain imaging at 1050 nm, 4545 
peripheral vision and self-induced motion in, 3253 
plasma-soluble Fas ligand and, 1345 
prevalence and risk factors in elderly Chinese population, 3126 
protection from membrane attack complex formation on murine RPE, 4126 
racial and other risk factors for, 2395 
repeatability of visual acuity scores in, 4347 
Toll-like receptor polymorphisms and, 1652 
visual outcome after RPE–choroid translocation in, 758 
Age-related maculopathy (ARM) 
macular vs. peripheral drusen in, 1200 
measuring rod and cone dynamics in, 55 
Akt pathway 
IGF-1R/PI3K/AKT signaling in rod outer segments, 4765 
PI3K/Akt signaling in regulation of Nrf2-dependent antioxidant functions in RPE, 1671 
PI3K/Akt signaling in uveal melanoma cell migration, 497 
Albinism 
autosomal recessive ocular albinism in Caucasian patients, 868 
OA1 and Gαi3 in melanosomal biogenesis and optic pathway formation (mouse), 3245 
optic nerve projections in human carriers of oculocutaneous albinism type 1a, 2756 
VEP and fMRI in identification of, 238 
Albumin, transscleral albumin permeability, 4041 
Aldehyde dehydrogenase, gene expression of mouse corneal crystallin Aldh3a1, 1814 
Aldose reductase inhibitor, inhibition of pericyte loss and endothelial cell growth by, 3216 
ALK1 gene transfection, remodeling retinal neovascularization by, 4553 
Alzheimer disease, amyloid-β and retinal degeneration in mouse model of, 5136 
Amblyopia 
anisometropia, amblyopia, and stereoacuity in school children with high prevalence of astigmatism, 4427 
color and motion VEPs in strabismic amblyopia, 4418 
effect on fine motor skills in children, 594 
temporal instability in amblyopic vision, 3940 
α-Aminoadipate, induction of progenitor cell properties of Müller glia (mouse), 1142 
5-Aminoimidazole-4-carboxamide riboside (AICAR), anti-inflammatory effects in RPE cells, 1274 
Amniotic membrane extract, suppression of apoptosis in RAW264.7 cells by, 4468 
Amniotic membrane transplantation, effect on healing of bacterial keratitis (rat), 163 
AMPA receptor subunits in developing rabbit retina, 5619 
Amyloid β 
accumulation of, and upregulation of angiogenic factors in ARPE19 cells, 2376 
and retinal degeneration in mouse model of Alzheimer disease, 5136 
Anandamide-induced increase in aqueous outflow facility, 4528 
Anatomy 
anterior limiting lamina–stroma interface, 3914 
overlapping of retinal nerve fibers in horizontal plane, 1753 
Angiogenesis. See also Neovascularization 
amyloid β accumulation and upregulation of angiogenic factors in ARPE19 cells, 2376 
corneal, drug modification of (rat), 250 
cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells, 1242 
dexamethasone inhibition of inflammatory and angiogenic mediators, 2030 
differential suppression by NSAIDs (mouse), 3909 
improved corneal graft survival due to ZK 261991-blocked angiogenesis, 1836 
role of FHL2 gene in (mouse), 5314 
triamcinolone acetonide inhibition of, 1184 
Angiopoietin-like 7 protein, glaucoma and, 3438 
Angiopoietin/Tie-2 system, in pericyte survival and recruitment in diabetic retinopathy, 2163 
Angiotensin (1–7), IOP reduction by (rabbit), 2557 
Angiotensin II type 1 receptor blockade, inhibition of neovascularization by (mouse), 4370 
Animal models 
abnormal reactivity of Müller cells after retinal detachment in mice deficient in GFAP and vimentin, 3659 
β2-adrenergic receptor signaling–mediated corneal epithelial wound repair (mouse), 1857 
α-2 adrenergic receptor subtypes and diurnal IOP variation (mouse), 929 
age-related cataract induced by targeted knockout of βB2-crystallin gene (mouse), 5476 
age-related changes in rat corneal epithelial nerve density, 910 
age-related cone abnormalities in zebrafish with genetic lesions in sonic hedgehog, 4631 
AMD-like lesions in rat retina after perinatal hemorrhage, 2790 
amelioration of vitreous abnormalities in diabetes by inhibitor of albumin glycation (rat), 5089 
AMPA receptor subunits in developing rabbit retina, 5619 
amyloid-β and retinal degeneration in mouse model of Alzheimer disease, 5136 
anti-inflammatory effects of C. longa and B. aristata in endotoxin-induced uveitis (rabbit), 4036 
apolipoprotein E mimetic peptide treatment of ocular herpetic stromal keratitis (mouse), 4263 
apoptosis after Pseudomonas aeruginosa keratitis delayed by substance P (mouse), 4458 
association of PTB-1B with c-Met receptor and modulation of corneal wound healing (rabbit), 2927 
astaxanthin inhibition of choroidal neovascularization (mouse), 1679 
astigmatism in experimental myopia or hyperopia (chicken), 858 
autoimmune optic neuritis in Marmoset monkeys, 3707 
autologous partial thickness RPE-choroid transplantation (rabbit), 3185 
azurocidin in diabetic blood-retinal barrier breakdown (rat), 726 
basic fibroblast growth factor in retinoblastoma progression and survival (mouse), 5215 
BDNF and survival of retinal dopaminergic neurons (guinea pig), 1282 
BDNF protection of ganglion cell morphology after optic nerve injury (cat), 2456 
biodegradable collagen–glycosaminoglycan polymer for scleral buckling (rabbit), 2673 
bone marrow–derived microglia in retina (mouse), 4162 
canine model of inherited myopia, 4784 
canine model of late infantile neuronal ceroid lipofuscinosis, 2686 
caspase 1 and ERK in inflammation-induced inhibition of lacrimal gland protein secretion (mouse), 4392 
cell communication mechanisms in vertebrate retina (Proctor Lecture), 5184 
ceruloplasmin/hephaestin knockout mouse model of AMD, 2728 
change in embryonic eye size and retinal cell proliferation after glycosaminoglycan injection (chick), 3289 
characterization of Ca2+-binding protein 5 knockout mouse retina, 5126 
characterization of spontaneous mouse RPE cell line B6-RPE07, 3699 
chloride channels and acinar cell volume in rabbit lacrimal gland, 5517 
5-chlorouracil delivery using poly(ortho esters) in filtering surgery for glaucoma (rabbit), 2993 
choroidal neovascularization in LOXL1-deficient mice, 2599 
choroidal vessel abnormalities in mice lacking TIMP-3, 2813 
ciliary body forward accommodative movement facilitated by zonular attachments to lens capsule (monkey), 5495 
circadian regulation of retinoschisin in chick retina, 1615 
clinical time-course of experimental autoimmune uveoretinitis (mouse), 5458 
CNTF modulation of electrical retinal stimulation thresholds (rat), 372 
comparison of anterior segment structures in two rat glaucoma models, 2478 
cones in rhodopsin mutant P23H-3 retina (rat), 1116 
connexin43 knockdown in corneal wound healing (rat), 93 
corneal wound healing in osteopontin-deficient mouse, 1367 
CRP-induced retinal vascular dysfunction (pig), 2053 
αA-crystallin–associated photoreceptor protection in experimental uveitis (mouse), 1161 
CXCL8, CLCR1, and CXCR2 expression in human and rabbit retina, 4578 
delay of retinal degeneration in rd10 mouse by gene therapy, 4278 
dense nuclear cataract caused by γB-crystallin mutation (mouse), 304 
detection of corneal fibrosis by imaging second harmonic–generated signals (rabbit), 4377 
development of refractive status and ocular growth in C57BL/6 mice, 5208 
developmental changes in conjunctiva-associated lymphoid tissue (rabbit), 644 
differential suppression of corneal angiogenesis by NSAIDs (mouse), 3909 
differentiation and production of action potentials by embryonic rat retina stem cells, 5144 
drug modification of corneal angiogenesis (rat), 250 
duplication and divergence of zebrafish CRALBP genes, 3812 
duration of binocular decorrelation and latent nystagmus in strabismic monkeys, 1872 
dynamic imaging of retinal microglia with time-lapse confocal microscopy (mouse), 4169 
early inner retinal dysfunction in streptozotocin-induced diabetic rats, 3595 
effect of amniotic membrane transplantation on healing of bacterial keratitis (rat), 163 
effect of eye pigmentation on transscleral drug delivery (rat), 333 
effect of methylprednisolone on RGCs and visual function after ocular ischemia (rat), 5003 
effect of surgical intervention on lens and ciliary body function in monkeys, 5484 
effect of thioltransferase deletion on cellular sensitivity to oxidative stress in lens epithelial cells (mouse), 4497 
effects of anti–VEGF-A monoclonal antibody on murine choroidal neovascularization, 1178 
effects of λ-carrageenan on replication of feline herpesvirus (cat), 1496 
effects of LINGO-1 antagonists on RGC survival after ocular hypertension and optic nerve transection (rat), 975 
effects of lipid raft disruption in Pseudomonas aeruginosa keratitis (mouse), 1000 
effects of photocoagulation on intraretinal PO2 (cat), 380 
effects of triamcinolone acetonide on leukocyte dynamics in rat retinal microcirculation, 2127 
efficacy of intravitreal and intracerebral rituximab injections in lymphoma (mice), 4738 
electrically invoked intrinsic signals in monkey retina, 2193 
elevated MMP expression in MRL mouse retina, 1686 
endoscopic vitrectomy in keratoprosthesis exchange (rabbit), 4407 
endothelin-1 effect on fast axonal transport in rat optic nerve, 961 
engrafted chicken neural tube–derived stem cells support axonal regeneration in rat optic nerve, 3513 
erythropoietin protection of retinal cells in diabetes (rat), 732 
estrogen and regulation in regulation of meibomian gland gene expression (mouse), 1797 
evaluating neural activity of RGCs in macaque retina, 4655 
evaluation of new photosensitizer Stakel for PDT (rabbit and rat), 1633 
failure of Rpe65−/−/Nrl−/− mice to generate cone outer segments, 1126 (erratum, 1762) 
fiber cell beaded filament and lens structural stability (mouse), 1030 
FoxE3 expression during lens fiber differentiation (mouse), 4269 
functional rescue of degenerating photoreceptors in Pde6bH620Q mice, 5067 
gene expression changes in porcine retinal detachment, 1262 
gene expression in rats that are susceptible or resistant to EAU, 1957 
gene expression of mouse corneal crystallin Aldh3a1, 1814 
gene profiling of retinal detachment and reattachment (mouse), 511 
genetic modifiers of retinal degeneration in rd3 mouse, 2863 
Gif1 mutation, lens development, and small-eye mouse phenotype, 1525 
glucosamine inhibition of endotoxin-induced uveitis (rat), 5441 
GPR48 regulation of epithelial cell proliferation and migration during eyelid development (mouse), 4245 
heme oxygenase-1 in corneal wound healing (mouse), 3379 
HIF-1 as age-dependent regulator of lens cell proliferation (mouse), 4961 
high-frequency ultrasound of choroidal melanoma xenograft volume (rat), 16 
human Müller stem cell transplantation in rat glaucoma, 3449 
hydrodynamic and morphologic changes in aqueous humor outflow pathway after IOP elevation (cow), 5346 
N-(4-hydroxyphenyl) retinamide and choroidal neovascularization (mouse), 1210 
hypermucoviscosity as virulence factor in Klebsiella pneumoniae endophthalmitis (mouse), 4931 
identification of photoreceptor precursors in pars plana (mouse), 422 
IL-6 as photoreceptor neuroprotectant in experimental retinal detachment (mouse, rat), 3193 
imaging of mouse RGC death in vivo, 5546 
imaging technique for anterior and posterior segments (mouse), 5168 
imbalance in cysteine proteinase cathepsins and cystatin C in rd1 mouse retina, 1089 
inducible expression of Cre recombinase in RPE (mouse), 1248 
induction of photoreceptor phenotype by exogenous Crx expression in mouse retinal stem cells, 429 
influence of quantitative trait locus on mouse chromosome 19 to cone ERG, 4058 
inhibition of crystallin ascorbylation in mouse model of lenticular aging, 4945 
inhibition of neovascularization by blocking angiotensin II type 1 receptor (mouse), 4370 
in vivo imaging of RGCs (macaque), 467 
in vivo labeling of mammalian cones, 2643 
interaction of CaBP4 and Unc119 in photoreceptors (mouse), 2366 
intratissue refractive index shaping of cornea and lens (cat), 5332 
intravitreal colchicine effects on RNFL (monkey), 255 
IOP elevation and glaucomatous changes in mice, 613 
IOP reduction by angiotensin (1–7) (rabbit), 2557 
ischemic tolerance in rat retina induced by lipopolysaccharide, 4604 
Klf4 target genes in mouse cornea, 3360 
lack of IFN-γ synthesis in aqueous humor during corneal graft rejection and suppressed NO production by macrophages (rat), 4923 
leukocytes in HSV-infected corneas without herpes stromal keratitis (mouse), 1488 
light-induced retinal changes observed with high-resolution autofluorescence imaging of RPE (macaque), 3715 
lipofuscin pigments in RPE of abca4-/- mice after vitamin A supplementation, 3821 
long-term vision rescue by human neural progenitors in rat model of photoreceptor degeneration, 3201 
manganese-enhanced MRI of DBA/2J mouse model of hereditary glaucoma, 5083 
mapping of neonatal Fc receptor in rodent eye, 2025 
MCP-1 deficiency and retinal neovascularization in murine ischemic retinopathy, 4195 
measurement of glucose utilization in cone-dominant ground squirrel retina, 4613 
mechanisms of murine lacrimal gland repair, 4399 
mediation of cannabidiol anti-inflammation in retina by equilibrative nucleoside transporter and A2A adenosine receptor (rat), 5526 
metabolic properties of rat oculorotatory EOMs, 4865 
mitochondrial OPA1 release in glaucomatous optic nerve (mouse), 4903 
mitomycin C–induced corneal endothelial DNA damage (goat), 4837 
Müller cell response to blue light injury of rat retina, 3559 
multifocal ERG in rhodopsin P347L transgenic pigs, 2208 
murine CMV infection and apoptosis in retinal cultures, 295 
murine model for lipid metabolism dysfunction, 1307 
murine model of Bruch membrane lipoidal degeneration, 390 
murine model of dry eye, 1386 
myogenic growth factors decrease EOM force generation (rabbit), 221 
neuronal NO in lactate-induced vasodilation (minipig), 5060 
neuroprotective effects of somatostatin in rat retina, 3081 
neutrophil chemotaxis and IL-10 expression in tolerance of endotoxin-induced uveitis (rat), 5450 
neutrophil protection of retina in HSV-1–injected eye (mouse), 4018 
new pathogenic epitopes of IRBP in EAU (mouse), 1946 
NMDA relaxation of porcine retinal arterioles via adenosine receptors, 4590 
NO in regulation of retinal blood flow in response to hyperoxia (cat), 4595 
NOD2 in murine muramyl dipeptide–induced uveitis, 1518 
non-mitogenic anti-CD3F(ab′)2 monoclonal antibody for herpetic stromal keratitis (mouse), 5425 
novel allele of Crybb2 in mouse and its expression in brain, 1533 
objective vision testing for inherited retinal disease (dog), 3568 
ocular safety of intravitreal infliximab (rabbit), 1151 
orbital drainage of radiolabeled colloids (rabbit), 2563 
osteopontin expression in rat retina after injury, 762 
oxidative stress-induced alterations in lysosomal function in porcine TM cells, 3961 
Oxr1 in hyperoxia-challenged mouse retina, 4561 
oxygen-induced neovascularization independent of VEGF in ROP (rat), 1591 
paclitaxel-releasing polytetrafluoroethylene/polylactide-co-glycolide laminate after strabismus surgery (rabbit), 5340 
(+)-pentazocine protection against retinal neurodegeneration (mouse), 4154 
periocular triamcinolone enhances intraocular gene expression after adenoviral delivery (mouse), 399 
peripheral refraction in infant monkeys, 3747 
pharmacokinetics of intraocular drug delivery of Oregon Green–labeled triamcinolone by subtenon injection (rabbit), 4506 
pharmacologic activity of Physalis peruviana fruit juice (rabbit), 3074 
phase-contrast OCT of transverse flows in mouse retina and choroid, 5055 
photoreceptor preservation in murine retinal detachment, 781 
photoreceptor protection after PDT using dexamethasone (rat), 5008 
phototopic ERG from amacrine cell signaling in RCS rat retinal degeneration, 442 
primate model of NAION, 2985 
protection from membrane attack complex formation on murine RPE in AMD, 4126 
protective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in rabbit subretinal hemorrhage, 4071 
protective effect of saffron supplement on retinal stress (rat), 1254 
protective effects of CD1d-reactive invariant NK cells in corneal inflammation (mouse), 105 
protective effects of proinsulin in mouse model of RP, 4188 
protective effects of thioredoxins 1 and 2 in RGCs after optic nerve transection (rat), 3535 
Prox1 in regulation of chicken βB1-crystallin promoter, 1542 
Prpf3 knockout mice and zebrafish, 3830 
quantification of ischemic damage in rat retina, 1056 
rabbit dry eye induced by benzalkonium chloride, 1850 
rabbit model of RPE transplantation, 4115 
reactivation of uveitogenic T cells by retinal astrocytes (mouse), 282 
real-time in vivo imaging of retinal cell apoptosis after laser exposure (rat), 2773 
recording focal macular photopic negative response from monkeys, 3544 
recovery of rod photoreceptors in ABCR-deficient mice, 2743 
recruitment of retinal microglia and uveal tract dendritic cells and macrophages in young mouse eye, 1599 
regulatory T cells in experimental autoimmune uveitis (rat), 3999 
reprogramming progeny cells of embryonic chick RPE to produce photoreceptors, 4145 
rescue in RCS rats after late-stage RPE transplantation, 416 
restoration of lysosomal pH in RPE cells (mouse), 772 
retinal changes in early-onset cone–rod dystrophy (dog), 1106 
retinal effects of postnatal hyperoxia in neonatal rat, 458 
retinal Frizzled-5 in regulation of hyaloid vitreous vasculature development (mouse), 5561 
retinal microglia activation and optic nerve integrity with minocycline in murine glaucoma, 1437 
retinal ON pathway defect in myopia (mouse), 706 
retinal pathology in α1 integrin-null mice, 4647 
retinal response to repeated IOP challenge (rat), 3026 
retinal VLDLR expression and neovascularization in knockout mouse model of retinal angiomatous proliferation, 407 
retinol dehydrogenases RDH11 and RDH12 in mouse retina, 1071 
RGC abnormalities in Ins2Akita diabetic mice, 2635 
RhoA and synaptic plasticity of salamander photoreceptors, 4177 
rhodamine 6G toxicity in rat retina, 2120 
RNA expression atlas of RP genes in human and mouse retina, 2330 
RNFL birefringence and thickness and ERG after optic nerve transection (monkey), 4444 
role of Acvr1 in lens development (mouse), 4953 
role of FHL2 gene in angiogenesis (mouse), 5314 
role of P2X7 in cornea (mouse), 4384 
Rpe65−/− and Lrat−/− murine models of Leber congenital amaurosis, 2384 
secretoglobins in rabbit lacrimal glands, 2856 
selective degeneration of central photoreceptors after hyperbaric oxygen (mouse), 3207 
separation of two populations of mouse limbal stem cells, 3903 
sialoadhesin expression in degenerating retinas after transplantation (mouse), 5602 
Stat6-independent inflammation of IκBζ−/− mice, 3387 
statin modulation of HSP expression and RGC survival after retinal ischemia/reperfusion (rat), 4971 
structural factors that mediate scleral stiffness (pig), 4232 
subconjunctival topotecan in fibrin sealant in murine retinoblastoma, 490 
substance P promotes susceptibility to Pseudomonas aeruginosa keratitis (mouse), 1502 
superior oblique palsy and torsional optokinetic nystagmus (monkey), 1421 
suppression of choroidal neovascularization by thioredoxin-1 interaction with complement factor H (mouse), 5118 
suppression of choroidal neovascularization by vaccine derived from VEGFR2 (mouse), 2143 
suppression of corneal neovascularization by dendritic cell immunization against VEGFR2 (mouse), 2172 
susceptibility of ovine lens crystallins to proteolytic cleavage in hereditary cataract, 1016 
synaptic pathology in retinoschisis knockout mouse retina and modification by gene therapy, 3677 
tauroursodeoxycholic acid preservation of photoreceptors in rd10 mice through postnatal day 30, 2148 
3-D two-photon imaging of conjunctiva-associated lymphoid tissue (mouse), 1512 
thyroid hormone required for cone opsin expression during retinal development (mouse), 2039 
thyroxine effects on embryonic chick corneal innervation, 139 
time-dependent effects of elevated IOP on optic nerve head axonal transport (pig), 986 
TNF-α in pathogenesis of Bacillus cereus endophthalmitis (mouse), 4482 
topical doxycycline induction of BDNF in RPE cells (rat), 3631 
transcriptional analyses after CCR3 blockade of hypersensitivity reactions in experimental allergic conjunctivitis (mouse), 5307 
Tyr43His mutant of human myocilin protein in glaucoma (mouse), 1932 
VEGF antibody decreases tortuosity in rat ROP model, 3107 
VEGF165 inhibition enhances PDT efficacy in ocular neovascularization (mouse), 662 
vertical pursuit in monkeys with acute superior oblique palsy, 3927 
visual phenotype of Rpe65rd12 and rd/rd mice, 2737 
zeaxanthin effects on retinal metabolic abnormalities in diabetic rats, 1645 
Zeb1 mutant mouse model of posterior corneal dystrophy, 1843 
Anisometropia, amblyopia, and stereoacuity in school children with high prevalence of astigmatism, 4427 
Anterior chamber 
angle measurement with anterior segment OCT, 3469 
heritability of anterior chamber depth in Chinese, 81 
shared genetic determinant of axial length, anterior chamber depth, and angle opening distance, 4790 
Anterior ischemic optic neuropathy (AION), RGC apoptosis induced by (rat), 3671 
Anterior segment 
comparison of anterior segment structures in two rat glaucoma models, 2478 
effects of cyclic IOP on conventional outflow facility, 275 
imaging technique for posterior segment and (mouse), 5168 
Anti-CD3F(ab′)2 monoclonal antibody for herpetic stromal keratitis (mouse), 5425 
Antihypertensive therapy 
effects of timolol-dorzolamide fixed combination vs. latanoprost on circadian diastolic ocular perfusion pressure in glaucoma, 4226 
latanoprost-induced collagen gel contraction, 1429 
modification of corneal angiogenesis (rat), 250 
Antimicrobial peptides, defensin beta-109 expression on ocular surface in inflammation and infection, 28 
Antimicrobial therapy 
efficacy of riboflavin/UVA combination treatment, 3402 
improving therapeutic regimens for Bacillus endophthalmitis, 1480 
topical doxycycline induction of BDNF in RPE cells (rat), 3631 
Antioxidants 
antioxidant effect of quercetin in human RPE, 1712 
antioxidant function of p53 in RGCs, 4237 
and cataract in North Indian population, 3328 
effects of RPE melanosomes on photosensitized and iron-mediated oxidation, 2838 
mitochondrial complex I defect in primary open-angle glaucoma TM cells, 1447 
PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in RPE, 1671 
zeaxanthin effects on retinal metabolic abnormalities in diabetic rats, 1645 
Zip2 modulation of Nrf2-dependent antioxidant functions in RPE, 1665 
Apolipoprotein E mimetic peptide treatment of ocular herpetic stromal keratitis (mouse), 4263 
Apoptosis and cell death 
after Pseudomonas aeruginosa keratitis delayed by substance P (mouse), 4458 
anti-apoptotic effects of TFF1 in conjunctival cells, 3790 
anti-apoptotic role of αB-crystallin in RPE cells, 4753 
αA-crystallin–associated photoreceptor protection in experimental uveitis (mouse), 1161 
delayed by protective effects of proinsulin in mouse model of RP, 4188 
effects of LINGO-1 antagonists on RGC survival after ocular hypertension and optic nerve transection (rat), 975 
FKBP8 in RPE apoptosis, 1721 
murine CMV infection and apoptosis in retinal cultures, 295 
protection against apoptosis by exogenous glutathione in Leber hereditary optic neuropathy, 671 
protective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in rabbit subretinal hemorrhage, 4071 
protective effect of saffron supplement on retinal stress (rat), 1254 
rat AION induces RGC apoptosis, 3671 
real-time in vivo imaging of retinal cell apoptosis after laser exposure (rat), 2773 
suppression in RAW264.7 cells by amniotic membrane extract, 4468 
Aquaporin-0, gene profiling of retinal detachment and reattachment (mouse), 511 
Aqueous humor 
anandamide-induced increase in aqueous outflow facility, 4528 
circadian variation of aqueous dynamics, 1473 
in glaucoma, angiopoietin-like 7 protein elevation in, 3438 
hydrodynamic and morphologic changes in aqueous humor outflow pathway after IOP elevation (cow), 5346 
lack of IFN-γ synthesis in aqueous humor during corneal graft rejection and suppressed NO production by macrophages (rat), 4923 
levels of VEGF in RP, 3499 
pharmacologic inhibition of GGTase-I and outflow of, 2464 
soluble gp130 in uveitis aqueous humor, 3988 
Arachnoid granulations, ex vivo model of CSF outflow across, 4721 
Artificial cornea, construction from collagen–chondroitin sulfate foams and human cell cultures, 5325 
ARVO/Pfizer Ophthyalmics Research Institute Conference, drug delivery to posterior intraocular tissues, 4712 
Asian populations 
complement factor H polymorphism and AMD in Chinese, 3312 
corneal biomechanical characteristics and refractive error in Singaporean children, 3852 
effect of progressive addition lenses on myopia progression in Japanese children, 2781 
estimating rate of progressive visual field damage in open-angle glaucoma, 66 
heritability of anterior chamber depth in Chinese, 81 
heritability of central corneal thickness in Chinese, 4303 
heritability of iridotrabecular angle width in Chinese children, 1356 
heritability of optic disc and cup in Chinese, 1350 
interleukin gene polymorphisms in AMD, 693 
LOXL1 polymorphisms and pseudoexfoliation in Japanese, 3976 
prevalence and risk factors of AMD in elderly Chinese population, 3126 
prevalence and types of glaucoma in Malay people, 3846 
retinal vascular narrowing in Asian eyes with glaucoma, 5397 
retinal vessel caliber, blood pressure, and cardiovascular risk factors in, 1784 
shared genetic determinant of axial length, anterior chamber depth, and angle opening distance, 4790 
spectacle acceptance among rural Chinese children, 2895 
visual function and myopia in rural Chinese children, 2888 
Astaxanthin, inhibition of choroidal neovascularization (mouse), 1679 
Astigmatism 
anisometropia, amblyopia, and stereoacuity in school children with high prevalence of, 4427 
dominant genetic effects on, 1339 
in experimental myopia or hyperopia (chicken), 858 
Astrocytes 
effect of TGF-β2 in human optic nerve astrocytes, 1464 
oxidative stress and TGF-β2–induced HSP27 expression in optic nerve head astrocytes, 5403 
reactivation of uveitogenic T cells by retinal astrocytes (mouse), 282 
ATM gene variants in idiopathic perifoveal telangiectasia, 3806 
Atmospheric pressure and temperature influences on IOP, 5392 
Attentional visual field, effect of cognitive and vision loss on topography of, 4672 
Authentication of cell lines in ophthalmic research laboratories, New Developments, 4697 
Autoimmune optic neuritis in Marmoset monkeys, 3707 
Axial length 
and corneal curvature in children with congenital/infantile cataract, 4774 
diurnal variation of axial length, IOP, and anterior eye biometrics, 2911 
shared genes in refraction and, 4336 
shared genetic determinant of axial length, anterior chamber depth, and angle opening distance, 4790 
Axons 
age-related losses of RGCs and, 4437 
endothelin-1 effect on fast axonal transport in rat optic nerve, 961 
engrafted chicken neural tube–derived stem cells support axonal regeneration in rat optic nerve, 3513 
time-dependent effects of elevated IOP on optic nerve head axonal transport (pig), 986 
Azurocidin, in diabetic blood-retinal barrier breakdown (rat), 726 
B
B-RAF mutations in uveal melanoma, 23 
Bacillus endophthalmitis 
improving therapeutic regimens for, 1480 
TNF-α in pathogenesis of (mouse), 4482 
Balance measures and motion-detection threshold in older adults, 5257 
Barbados Eye Studies, impact of glaucoma, lens opacities, and cataract surgery on visual functioning and quality of life, 1333 
Basic fibroblast growth factor, in retinoblastoma progression and survival (mouse), 5215 
Bayesian machine learning classifiers for combining structural and functional measurements in glaucoma, 945 
Behçet disease, with active uveitis, IL-23 and IL-17 in, 3058 
Benzalkonium chloride, rabbit dry eye induced by, 1850 
Benzo(e)pyrene, effects on RPE cells, 5111 
Berberis aristata, anti-inflammatory effects in endotoxin-induced uveitis (rabbit), 4036 
Best macular dystrophy, retinal function in, 5553 
Bestrophin-2, in generation of IOP, 1563 
Bevacizumab 
compared with ranibizumab and pegaptanib in vitro, 4523 
effects on retinal cells in organotypic culture, 3164 
interaction between murine VEGF-A and, 522 
subretinal detection after intravitreous injection (rabbit), 1097 
BF gene variants, in Chinese patients with polypoidal choroidal vasculopathy, 2613 
Binocular vision 
duration of binocular decorrelation and latent nystagmus in strabismic monkeys, 1872 
posterior parietal cortex effects on binocular coordination, 230 
Biomaterials 
artificial cornea construction from collagen–chondroitin sulfate foams and human cell cultures, 5325 
biodegradable collagen–glycosaminoglycan polymer for scleral buckling (rabbit), 2673 
factors affecting perceptual thresholds in epiretinal prostheses, 2303 
hyaluronic acid-chitosan nanoparticles for ocular gene therapy, 2016 
innervation of tissue-engineered recombinant human collagen-based corneal substitutes, 3895 
paclitaxel-releasing polytetrafluoroethylene/polylactide-co-glycolide laminate after strabismus surgery (rabbit), 5340 
predicting vitreous hemorrhage clearance after Vitrase injection in diabetic patients, 4219 
tissue-engineered recombinant human collagen-based corneal substitutes for implantation, 3887 
Biomechanics 
corneal biomechanical characteristics and refractive error in Singaporean children, 3852 
model of effect of viscosity and elasticity on hysteresis, 3919 
role of lens capsule on mechanical accommodative response in a lens stretcher, 4490 
structural factors that mediate scleral stiffness (pig), 4232 
Blebbistatin, prevention of inhibitory effects of thrombin on intercellular calcium wave propagation by, 4816 
Blink, measuring higher-order aberrations after blinking in dry eye, 133 
Blood flow 
NO in regulation of retinal blood flow in response to hyperoxia (cat), 4595 
phase-contrast OCT of transverse flows in mouse retina and choroid, 5055 
retinal and choroidal, indomethacin effect on, 1065 
Blood pressure 
effect of aging on retinal artery blood column diameter, 2094 
retinal vessel caliber, blood pressure, and cardiovascular risk factors in Asian population, 1784 
Blood-retinal barrier, azurocidin in diabetic blood-retinal barrier breakdown (rat), 726 
Bone marrow–derived microglia in retina (mouse), 4162 
Bothnia dystrophy, RLBP1 and CAIV mutations in, 3172 
Brain 
effect of age and fixation instability on retinotopic mapping of primary visual cortex, 3734 
ex vivo model of CSF outflow across human arachnoid granulations, 4721 
Listing’s law in skew deviation due to brainstem or cerebellar lesions, 204 
novel allele of Crybb2 in mouse and its expression in, 1533 
posterior parietal cortex effects on binocular coordination, 230 
Brain-derived neurotrophic factor (BDNF) 
effect of electrical stimulation on BDNF induction in Müller cells, 4641 
protection of ganglion cell morphology after optic nerve injury (cat), 2456 
and survival of retinal dopaminergic neurons (guinea pig), 1282 
topical doxycycline induction of (rat), 3631 
Branch retinal vein occlusion (BRVO), effect of dorzolamide on retinal oxygen tension in (pig), 1136 
Bruch’s membrane 
aging, lipoprotein-like particle accumulation in, 2721 
lipoidal degeneration, murine model, 390 
Bulbar redness grading scales, accuracy of, 1398 
C
C-reactive protein (CRP), retinal vascular dysfunction induced by (pig), 2053 
C2 gene variants, in Chinese patients with polypoidal choroidal vasculopathy, 2613 
CaBP4, interaction with Unc119 in photoreceptors (mouse), 2366 
Cadherins 
intercellular adherent junctions expressed by corneal endothelial cells, 3879 
VIP in maintenance of corneal endothelial differentiation state, 3491 
Caffeine consumption and glaucoma risk, 1924 
Calcium 
activation of store-operated Ca2+ channels in TM cells, 677 
blebbistatin prevention of inhibitory effects of thrombin on intercellular calcium wave propagation, 4816 
induction of amyloid β accumulation by ER calcium disruption and upregulation of angiogenic factors in ARPE19 cells, 2376 
mitochondrial defects and dysfunction in calcium regulation in glaucomatous TM cells, 4912 
muscarinic receptor-activated calcium influx in mouse Müller cells, 3065 
P2Y receptor subtypes regulate calcium signaling in RPE, 350 
sigma-1 receptor regulation of voltage-gated calcium channels, 4993 
Calcium-binding protein 5 knockout mouse retina, 5126 
Candidate gene studies 
CCL2, CCR2, and TLR4 genes in AMD, 364 
TCF8 in Fuchs endothelial corneal dystrophy, 184 
TGIF in myopia, 49 
Cannabidiol anti-inflammation in retina, mediation by equilibrative nucleoside transporter and A2A adenosine receptor (rat), 5526 
Cannabinoid receptors, in conjunctival epithelium, 4535 
Carbon dioxide, retinal arteriolar and middle cerebral artery responses to hypercarbic/hyperoxic stimuli, 5503 
Carbonic anhydrase IV, role in corneal endothelial function, 1048 
Cardiovascular disease 
cardiovascular risk factors for retinal vein occlusion, 4297 
retinal vessel caliber, blood pressure, and cardiovascular risk factors in Asian population, 1784 
Carnitive palmitoyltransferse I and acyl-CoA dehydrogenase 9 in retina, 1660 
Carotenoids 
antioxidants and cataract in North Indian population, 3328 
astaxanthin inhibition of choroidal neovascularization (mouse), 1679 
zeaxanthin effects on retinal metabolic abnormalities in diabetic rats, 1645 
λ-Carrageenan, effects on replication of feline herpesvirus (cat), 1496 
Caspase 1 and ERK in inflammation-induced inhibition of lacrimal gland protein secretion (mouse), 4392 
Caspase-12 gene, regulated expression in RPE, 5593 
Cataract 
age-related cataract induced by targeted knockout of βB2-crystallin gene (mouse), 5476 
antioxidants and cataract in North Indian population, 3328 
corneal curvature and axial length in children with congenital/infantile cataract, 4774 
dense nuclear cataract caused by γB-crystallin mutation (mouse), 304 
due to connexin50 mutants, 2549 
free and bound water in normal and cataractous lenses, 1991 
impact of glaucoma, lens opacities, and cataract surgery on visual functioning and quality of life, 1333 
intracellular aggregation of two cataract-associated γ-crystallin mutants, 3483 
susceptibility of ovine lens crystallins to proteolytic cleavage in hereditary cataract, 1016 
visual function and quality of life in elderly women with, 1 
Cataract surgery 
endophthalmitis after, PCR for bacterial identification in, 1971 
in pediatric patients, glaucoma risk after, 1791 (erratum, 2805) 
phacoemulsification and neovascular AMD, 1079 
resolution visual fields in children surgically treated for congenital cataract, 3730 
and risk of AMD, 4795 
Catenins, intercellular adherent junctions expressed by corneal endothelial cells, 3879 
Cathepsins, imbalance in cysteine proteinase cathepsins and cystatin C in rd1 mouse retina, 1089 
CCL2 in AMD, 364 
CCR2 in AMD, 364 
CCR3, transcriptional analyses after CCR3 blockade of hypersensitivity reactions in experimental allergic conjunctivitis (mouse), 5307 
CCR7, expression by uveal melanoma, 636 
Cell communication mechanisms in vertebrate retina (Proctor Lecture), 5184 
Cell cycle 
arrest by kynurenine in lens epithelial cells, 5466 
Rho/ROCK in corneal epithelial cell cycle regulation, 175 
Cell death. See Apoptosis and cell death 
Central corneal thickness, heritability in Chinese, 4303 
Cerebral palsy, visual sensory and motor deficits in children with, 572 
Cerebrospinal fluid (CSF), ex vivo model of CSF outflow across human arachnoid granulations, 4721 
CERKL mutations and associated phenotypes in autosomal recessive RP, 2709 
Ceruloplasmin/hephaestin knockout mouse model of AMD, 2728 
Chemokines and chemokine receptors 
CCL2 and CCR2 in AMD, 364 
control of chemokine gradients by RPE, 4620 
CXCL8, CLCR1, and CXCR2 expression in human and rabbit retina, 4578 
expression by uveal melanoma, 636 
poly(I:C) in immunoinflammatory response in cultured corneal fibroblasts, 3336 
recruitment of retinal microglia and uveal tract dendritic cells and macrophages in young mouse eye, 1599 
transcriptional analyses after CCR3 blockade of hypersensitivity reactions in experimental allergic conjunctivitis (mouse), 5307 
Chemotherapy 
5-chlorouracil delivery using poly(ortho esters) in filtering surgery for glaucoma (rabbit), 2993 
subconjunctival topotecan in fibrin sealant in murine retinoblastoma, 490 
Chennai Glaucoma Study, neural rim characteristics of healthy South Indians, 3457 
Chinese populations 
complement factor H polymorphism and AMD in, 3312 
estimating rate of progressive visual field damage in open-angle glaucoma, 66 
heritability of anterior chamber depth in, 81 
heritability of central corneal thickness in Chinese, 4303 
interleukin gene polymorphisms in AMD, 693 
shared genetic determinant of axial length, anterior chamber depth, and angle opening distance, 4790 
Chloride channels and acinar cell volume in rabbit lacrimal gland, 5517 
5-Chlorouracil, delivery using poly(ortho esters) in filtering surgery for glaucoma (rabbit), 2993 
Chondroitin sulfate 
artificial cornea construction from collagen–chondroitin sulfate foams and human cell cultures, 5325 
change in embryonic eye size and retinal cell proliferation after glycosaminoglycan injection (chick), 3289 
Choroideremia 
new type of mutations in, 1315 
syndromic, 4096 
Chromosomes 
influence of quantitative trait locus on mouse chromosome 19 to cone ERG, 4058 
monosomy of chromosome 3 and inflammatory phenotype in uveal melanoma, 505 
novel high myopia locus on 5p15, 3768 
Ciliary body 
effect of surgical intervention on lens and ciliary body function in monkeys, 5484 
forward accommodative movement facilitated by zonular attachments to lens capsule (monkey), 5495 
imaging technique for anterior and posterior segments (mouse), 5168 
thickness of, and refractive error in children, 4353 
versican and fibrillin-1 form hyaluronan-binding complex in, 2870 
Ciliary neurotrophic factor (CNTF), modulation of electrical retinal stimulation thresholds (rat), 372 
Circadian rhythms 
effects of timolol-dorzolamide fixed combination vs. latanoprost on circadian diastolic ocular perfusion pressure in glaucoma, 4226 
regulation of retinoschisin in chick retina, 1615 
variation of aqueous dynamics, 1473 
Climatic keratopathy droplets, proteomic analysis of, 2829 
Clinical trials 
effect of progressive addition lenses on myopia progression in Japanese children, 2781 
effect of soft contact lenses on myopia progression in children, 4702 
effects of timolol-dorzolamide fixed combination vs. latanoprost on circadian diastolic ocular perfusion pressure in glaucoma, 4226 
factors affecting perceptual thresholds in epiretinal prostheses, 2303 
indomethacin effect on retinal and choroidal blood flow, 1065 
nonpreserved care solutions and contact lens wear, 7 
OCT scan circle location and mean RNFL measurement variability, 2315 
OCT vs. fundus photography of retinal thickening in diabetic macular edema, 1745 
Ophthalmic Clinical Trial Design and Endpoints Symposium, 479 
predicting vitreous hemorrhage clearance after Vitrase injection in diabetic patients, 4219 
quantification of metamorphopsia in macular hole patients, 3741 
visual function and quality of life in elderly women with cataracts, 1 
CLRN1 gene mutations, retinal disease in Usher syndrome III due to, 2651 
Clusterin, in Fuchs endothelial corneal dystrophy, 2946 
Cognitive and vision loss, effect on topography of attentional visual field, 4672 
Colchicine, intravitreal, effects on RNFL (monkey), 255 
Collagen 
artificial cornea construction from collagen–chondroitin sulfate foams and human cell cultures, 5325 
collagen–glycosaminoglycan polymer for scleral buckling (rabbit), 2673 
distribution in human vitreoretinal interface, 4089 
effect of TGF-β2 in human optic nerve astrocytes, 1464 
inhibition of collagen degradation by IKK-2 inhibitor, 4850 
innervation of tissue-engineered recombinant human collagen-based corneal substitutes, 3895 
tissue-engineered recombinant human collagen-based corneal substitutes for implantation, 3887 
Colloids, orbital drainage of (rabbit), 2563 
Color vision 
color and motion VEPs in strabismic amblyopia, 4418 
effect of mild hypoxia on chromatic sensitivity, 820 
Complement 
complement-associated deposits in retina, 743 
protection from membrane attack complex formation on murine RPE in AMD, 4126 
Complement factor H (CFH)  
polymorphism in AMD 
in Chinese patients, 3312 
functional and structural implications of, 1763 
HTRA1 variants, smoking and, 2357 
measurement in plasma using monoclonal antibodies, 1983 
neovascular AMD in Koreans, 2071 
10q26 gene cluster variants in AMD risk in Indian patients and, 1771 
polymorphism in Chinese patients with polypoidal choroidal vasculopathy, 2613 
suppression of choroidal neovascularization by thioredoxin-1 interaction with (mouse), 5118 
Computed tomography, calculation of orbital soft tissue volumes, 1758 
Cone–rod dystrophy, early-onset, retinal changes in (dog), 1106 
Cones. See Photoreceptors 
Confocal blue reflectance, in type 2 idiopathic macular telangiectasia, 1172 
Confocal microscopy 
automatic recognition of corneal nerve structures in images from, 4801 
dynamic imaging of retinal microglia with (mouse), 4169 
effects of lipid raft disruption in Pseudomonas aeruginosa keratitis (mouse), 1000 
in vivo 
of conjunctival modifications in ocular hypertension and glaucoma, 3042 
of corneal wound healing after Epi-Lasik, 2416 
in keratoconus, 2964 
of sub-basal nerve plexus migration, 3409 
Confocal scanning laser ophthalmoscopy 
HRT-3 Glaucoma Probability Score vs. stereophotography for prediction of glaucoma progression, 1898 
longitudinal imaging of RGC damage with, 4898 
longitudinal variability of optic disc and RNFL measurements, 4886 
Congenital stationary night blindness, autosomal-dominant, novel rhodopsin mutation in, 4105 
Conjunctiva 
anti-apoptotic effects of TFF1 in, 3790 
cannabinoid receptors in conjunctival epithelium, 4535 
conjunctival and corneal sensitivity and dry eye, 2971 
ERK in conjunctival goblet cell proliferation, 3351 
in vivo confocal microscopy of conjunctival modifications in ocular hypertension and glaucoma, 3042 
mediators of HSV-1 entry into conjunctival epithelium, 4026 
regulation of TNFR1 in conjunctival epithelial cells, 3992 
Conjunctiva-associated lymphoid tissue 
3-D two-photon imaging of (mouse), 1512 
developmental changes in (rabbit), 644 
Conjunctivitis 
effects of λ-carrageenan on herpetic conjunctivitis in cats, 1496 
transcriptional analyses after CCR3 blockade of hypersensitivity reactions in experimental allergic conjunctivitis (mouse), 5307 
Connective tissue growth factor, as mediator of intraocular fibrosis, 4078 
Connexins 
cataracts due to connexin50 mutants, 2549 
connexin43 knockdown in corneal wound healing (rat), 93 
connexin43-mediated protection of ARPE-19 cells, 800 
identification of lens fiber connexin posttranslational modifications, 1553 
Contact lenses 
adsorption of tear film lipids to silicone hydrogels, 120 
CRTH rigid gas-permeable, epithelial thickness changes due to, 3345 
effect of soft contact lenses on myopia progression in children, 4702 
nonpreserved care solutions and contact lens wear, 7 
soft, effect on optical biometry, 3371 
Continuous positive airway pressure (CPAP)–related IOP increase in obstructive sleep apnea, 934 
Contrast sensitivity 
perimetry test in glaucoma, 3049 
and quality of life in elderly women with cataracts, 1 
retinal function in Best macular dystrophy, 5553 
time course of changes in ocular higher-order aberrations and contrast sensitivity after overnight orthokeratology, 4314 
Cornea 
anterior limiting lamina–stroma interface, 3914 
biomechanical model of effect of viscosity and elasticity on hysteresis, 3919 
conjunctival and corneal sensitivity and dry eye, 2971 
corneal biomechanical characteristics and refractive error in Singaporean children, 3852 
corneal curvature and axial length in children with congenital/infantile cataract, 4774 
corneal hysteresis and optic nerve surface compliance in glaucoma, 3262 
gene expression of mouse corneal crystallin Aldh3a1, 1814 
heritability of central corneal thickness in Chinese, 4303 
immunochemical localization of keratan sulfate proteoglycans in, 2424 
intratissue refractive index shaping of cornea and lens (cat), 5332 
involvement in rheumatoid arthritis, 560 
protective effects of CD1d-reactive invariant NK cells in corneal inflammation (mouse), 105 
role of P2X7 in (mouse), 4384 
suppression of corneal neovascularization by dendritic cell immunization against VEGFR2 (mouse), 2172 
thyroxine effects on embryonic chick corneal innervation, 139 
VEGF mediation of corneal nerve repair, 3870 
Corneal dystrophy 
posterior, Zeb1 mutant mouse model of, 1843 
TCF8 in Fuchs endothelial corneal dystrophy, 184 
Corneal endothelial cells 
blebbistatin prevention of inhibitory effects of thrombin on intercellular calcium wave propagation in, 4816 
intercellular adherent junctions expressed by, 3879 
mitomycin C–induced DNA damage in (goat), 4837 
role of carbonic anhydrase IV in function of, 1048 
toxic effects of rtPA on, 1392 
ubiquitination pathway for p27 degradation in, 189 
VIP in maintenance of corneal endothelial differentiation state, 3491 
Corneal epithelium 
β2-adrenergic receptor signaling–mediated wound repair in (mouse), 1857 
age-related changes in rat corneal epithelial nerve density, 910 
antiadhesive character of mucin O-glycans at apical surface of, 197 
corneal fibroblasts in differentiation of, 113 
delayed disruption of barrier function in cultured cells, 565 
effect of nonpreserved care solutions on 12 months of contact lens wear, 7 
protection from hypoxia-induced disruption of barrier function by KGF, 2432 
regulation of hyperosmolarity-induced cornification of, 539 
Rho/ROCK in regulation of cell cycle progression of, 175 
role of Rho in epithelial wound healing, 900 
serum- and feeder-cell–free culture of, 2438 
thickness changes due to CRTH rigid gas-permeable contact lenses, 3345 
Corneal fibroblasts 
in differentiation of corneal epithelial cells, 113 
hypersensitive response to oxidative stress in keratoconus, 4361 
poly(I:C) in immunoinflammatory response in cultured, 3336 
Corneal wound healing 
β2-adrenergic receptor signaling–mediated (mouse), 1857 
association of PTB-1B with c-Met receptor and modulation of (rabbit), 2927 
connexin43 knockdown in (rat), 93 
heme oxygenase-1 in (mouse), 3379 
human tissue–engineered model of, 1376 
independent of limbal stem cell influence, 5279 
in vivo confocal microscopic evaluation after Epi-Lasik, 2416 
JNK-paxillin signaling pathway in, 125 
NFI regulation of α6 integrin gene during, 3758 
in osteopontin-deficient mouse, 1367 
role of Rho in, 900 
Corticosteroids 
dexamethasone inhibition of inflammatory and angiogenic mediators, 2030 
effect of methylprednisolone on RGCs and visual function after ocular ischemia (rat), 5003 
effects of triamcinolone acetonide on leukocyte dynamics in rat retinal microcirculation, 2127 
gene expression profiles of human TM cells induced by triamcinolone and dexamethasone, 1886 
pharmacokinetics of intraocular drug delivery of Oregon Green–labeled triamcinolone by subtenon injection (rabbit), 4506 
photoreceptor protection after PDT using dexamethasone (rat), 5008 
protective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in rabbit subretinal hemorrhage, 4071 
retinal vascular caliber changes after intravitreal triamcinolone for diabetic macular edema, 4707 
triamcinolone acetonide inhibition of angiogenesis, 1184 
CRALBP genes, zebrafish, duplication and divergence of, 3812 
Cre recombinase expression in RPE (mouse), 1248 
Crx, induction of photoreceptor phenotype by exogenous Crx expression in mouse retinal stem cells, 429 
Crybb2, novel allele in mouse and its expression in brain, 1533 
Crystallins 
age-related cataract induced by targeted knockout of βB2-crystallin gene (mouse), 5476 
anti-apoptotic role of αB-crystallin in RPE cells, 4753 
anti-crystallin seroreactivity in uveitis, 4476 
αA-crystallin–associated photoreceptor protection in experimental uveitis (mouse), 1161 
dense nuclear cataract caused by γB-crystallin mutation (mouse), 304 
gene expression of mouse corneal crystallin Aldh3a1, 1814 
inhibition of crystallin ascorbylation in mouse model of lenticular aging, 4945 
intracellular aggregation of two cataract-associated γ-crystallin mutants, 3483 
Prox1 in regulation of chicken βB1-crystallin promoter, 1542 
susceptibility of ovine lens crystallins to proteolytic cleavage in hereditary cataract, 1016 
CTLA-4 and IL-13 gene polymorphisms associated with Graves’ disease and ophthalmopathy in Chinese children, 2409 
Culture studies 
abnormal cellular reactivity to microbial antigens in uveitis, 2526 
activation of store-operated Ca2+ channels in TM cells, 677 
amyloid β accumulation and upregulation of angiogenic factors in ARPE19 cells, 2376 
anti-inflammatory effects of AICAR in RPE cells, 1274 
antiadhesive character of mucin O-glycans at apical surface of corneal epithelial cells, 197 
antioxidant effect of quercetin in human RPE, 1712 
carnitive palmitoyltransferse I and acyl-CoA dehydrogenase 9 in retina, 1660 
cataracts due to connexin50 mutants, 2549 
cell cycle arrest by kynurenine in lens epithelial cells, 5466 
connexin43-mediated protection of ARPE-19 cells, 800 
control of chemokine gradients by RPE, 4620 
cornea limbal stem/progenitor cell transfection in organ culture model, 3395 
corneal fibroblasts in differentiation of corneal epithelial cells, 113 
corneal wound healing independent of limbal stem cell influence, 5279 
cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells, 1242 
dendritic cells and choroidal neovascularization, 3666 
development of reconstructed cornea from collagen–chondroitin sulfate foams and human cell cultures, 5325 
dexamethasone inhibition of inflammatory and angiogenic mediators, 2030 
diadenosine polyphosphate recruits RhoA/ROCK and ERK1/2 in cornea, 4982 
downregulation of MMP-2 and -9 by proteasome inhibition, 1998 
effect of curcumin on migration of retinal endothelial cells, 3305 
effect of electrical stimulation on BDNF induction in Müller cells, 4641 
effect of IL-1β on energy metabolism of R28 and RGC-5 retinal neurons, 5581 
effect of superimposed electromagnetic noise on DNA damage of lens epithelial cells, 2009 
effect of TGF-β2 in human optic nerve astrocytes, 1464 
effects of bevacizumab on retinal cells in organotypic culture, 3164 
effects on substrate rigidity on TM cells, 262 
EGF synergism with TGF-β1 in keratocyte differentiation, 2936 
ERK in conjunctival goblet cell proliferation, 3351 
FK506-binding protein 51 regulation of nuclear transport of glucocorticoid receptor β, 1037 
FKBP8 in RPE apoptosis, 1721 
glycosaminoglycan biosynthesis and outflow facility in perfusion culture, 2495 
HSP90 inhibition in uveal melanoma cells, 2348 
human tissue–engineered model of corneal wound healing, 1376 
hyaluronic acid-chitosan nanoparticles for ocular gene therapy, 2016 
N-(4-hydroxyphenyl) retinamide and choroidal neovascularization (mouse), 1210 
hypersensitive response to oxidative stress in keratoconus corneal fibroblasts, 4361 
inhibition of collagen degradation by IKK-2 inhibitor, 4850 
inhibition of pericyte loss and endothelial cell growth by aldose reductase inhibitor, 3216 
interaction between bevacizumab and murine VEGF-A, 522 
interactions between TM cells and lens epithelial cells in infantile aphakic glaucoma, 3981 
intercellular adherent junctions expressed by corneal endothelial cells, 3879 
intraretinal leakage and LDL oxidation in diabetic retinopathy, 2679 
iron regulates L-cystine uptake and glutathione levels, 310 
JNK-paxillin signaling pathway in corneal epithelial cell wound healing, 125 
KGF protection of corneal epithelial cells from hypoxia-induced disruption of barrier function, 2432 
latanoprost-induced collagen gel contraction, 1429 
late outgrowth endothelial progenitor cells in AMD, 2696 
lovastatin-inhibited myofibroblast transdifferentiation in Tenon fibroblasts, 3955 
mitochondrial complex I defect in primary open-angle glaucoma TM cells, 1447 
mitochondrial defects and dysfunction in calcium regulation in glaucomatous TM cells, 4912 
mitochondrial DNA oxidative damage in high glucose–induced human retinal endothelial cells, 4203 
murine CMV infection and apoptosis in retinal cultures, 295 
muscarinic receptor-activated calcium influx in mouse Müller cells, 3065 
nonpeptide somatostatin receptor agonists target ocular neovascularization, 5094 
occludin regulation of permeability in RPE cells, 2568 
OCTN1 and OCTN2 expression in ocular epithelium, 4844 
oxidative stress and TGF-β2–induced HSP27 expression in optic nerve head astrocytes, 5403 
P2Y receptor subtypes regulate calcium signaling in RPE, 350 
pharmacologic inhibition of GGTase-I and aqueous humor outflow, 2464 
PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in RPE, 1671 
PI3K/Akt signaling in uveal melanoma cell migration, 497 
picropodophyllin-inhibited growth of uveal melanoma, 2337 
podosome- or invadopodia-like structures for focal TM ECM turnover, 5353 
poloxamers for deswelling of organ-cultured corneas, 550 
poly(I:C) in immunoinflammatory response in cultured corneal fibroblasts, 3336 
prostaglandin analogue reduction of oxidative stress in TM, 4872 
proteasome as target of oxidative damage in RPE cells, 3622 
regulated expression of caspase-12 gene in RPE, 5593 
regulation of PEDF by Müller cells under hypoxia, 5161 
regulation of TNFR1 in conjunctival epithelial cells, 3992 
remodeling retinal neovascularization by ALK1 gene transfection, 4553 
reprogramming progeny cells of embryonic chick RPE to produce photoreceptors, 4145 
response of human TM cells to topographic cues on nanoscale level, 629 
restoration of lysosomal pH in RPE cells, 772 
resveratrol inhibition of uveal melanoma tumor growth, 1299 
retinal explant culture system as stem cell transplantation model, 3503 
Rho/ROCK in corneal epithelial cell cycle regulation, 175 
role of carbonic anhydrase IV in corneal endothelial function, 1048 
role of Rho in corneal epithelial wound healing, 900 
serum- and feeder-cell–free culture of corneal epithelium, 2438 
serum amyloid A in glaucoma, 1916 
serum-free culture of human prenatal RPE cells, 788 
sigma-1 receptor regulation of voltage-gated calcium channels, 4993 
SPRR1B as biomarker for squamous metaplasia in dry eye disease, 34 
squamous metaplasia of human limbal epithelium, 154 
sulforaphane protection of RPE cells against oxidative stress, 2606 
suppression of apoptosis in RAW264.7 cells by amniotic membrane extract, 4468 
system N glutamine transporters in RGCs, 5151 
Tie-2 in pericyte survival and recruitment in diabetic retinopathy, 2163 
tissue transglutaminase expression in glaucomatous trabecular tissue, 622 
toxic effects of rtPA on cultured corneal endothelial cells, 1392 
triamcinolone acetonide inhibition of angiogenesis, 1184 
TRPV1 modulation of IL-6 and NFκB with pressure (mouse), 3004 
UBE2E3 required for proliferation of RPE cells, 5611 
ubiquitination pathway for p27 degradation in corneal endothelial cells, 189 
UV radiation and MMPs in ocular surface squamous neoplasia, 5295 
VEGF induction of MEF2C in endothelial cells, 3640 
Zip2 modulation of Nrf2-dependent antioxidant functions in RPE, 1665 
Znt and ZIP zinc transporter expression in RPE, 1221 (erratum, 3811) 
Curcuma longa, anti-inflammatory effects in endotoxin-induced uveitis (rabbit), 4036 
Curcumin, effect on migration of retinal endothelial cells, 3305 
CXCR4, expression by uveal melanoma, 636 
Cyclic guanosine monophosphate (cGMP), role in somatostatin protection against retinal ischemia (rat), 342 
Cyclooxygenase inhibitors, indomethacin effect on retinal and choroidal blood flow, 1065 
Cystatin C, imbalance in cysteine proteinase cathepsins and cystatin C in rd1 mouse retina, 1089 
Cysts, macular, visual acuity related to parafoveal retinal thickness in patients with RP and, 4568 
Cytochrome P450 2C epoxygenases, in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells, 1242 
Cytokines 
association of CTLA-4 and IL-13 gene polymorphisms with Graves’ disease and ophthalmopathy in Chinese children, 2409 
IL-6 as photoreceptor neuroprotectant in experimental retinal detachment (mouse, rat), 3193 
IL-10 polymorphism in toxoplasmic retinochoroiditis, 1979 
Il-23 and IL-17 in Behçet disease with active uveitis, 3058 
IL13/IL-4R gene polymorphisms in Stevens-Johnson syndrome with ocular surface complications, 1809 
poly(I:C) in immunoinflammatory response in cultured corneal fibroblasts, 3336 
soluble gp130 in uveitis aqueous humor, 3988 
TRPV1 modulation of IL-6 and NFκB with pressure (mouse), 3004 
Cytomegalovirus (CMV) nfection and apoptosis in retinal cultures (mouse), 295 
D
Dark adaptation, measuring rod and cone dynamics in ARM, 55 
Defensin beta-109, expression on ocular surface in inflammation and infection, 28 
Dendritic cells 
choroidal neovascularization and, 3666 
in vivo response of phagocytes to laser-induced fundus damage (mouse), 3649 
recruitment of retinal microglia and uveal tract dendritic cells and macrophages in young mouse eye, 1599 
suppression of corneal neovascularization by dendritic cell immunization against VEGFR2 (mouse), 2172 
Deswelling of organ-cultured corneas, poloxamers for, 550 
Dexamethasone 
gene expression profiles of human TM cells induced by triamcinolone and, 1886 
inhibition of inflammatory and angiogenic mediators by, 2030 
photoreceptor protection after PDT using (rat), 5008 
Dextran sulfate, change in embryonic eye size and retinal cell proliferation after glycosaminoglycan injection (chick), 3289 
Diabetes mellitus 
advanced glycation impairment of vascular repair by endothelial progenitor cells, 1232 
amelioration of vitreous abnormalities by inhibitor of albumin glycation (rat), 5089 
azurocidin in diabetic blood-retinal barrier breakdown (rat), 726 
early inner retinal dysfunction in streptozotocin-induced diabetic rats, 3595 
erythropoietin protection of retinal cells in (rat), 732 
functional vision in diabetic low-vision patients, 4051 
heritability of severity of diabetic retinopathy, 3839 
impact of diabetic retinopathy on quantitative RNFL measurement and glaucoma screening, 687 
intraretinal leakage and LDL oxidation in, 2679 
local diabetic retinopathy prediction by multifocal ERG over 3 years, 1622 
LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment, 4746 
macular edema in 
ETDRS severity scale for, 5041 
OCT vs. fundus photography of retinal thickening in, 1745 
repeatability of Stratus and Cirrus OCT in, 4290 
retinal vascular caliber changes after intravitreal triamcinolone for, 4707 
predicting vitreous hemorrhage clearance after Vitrase injection in patients with, 4219 
reliability of retinal thickness measurements in, 2627 
retinal arteriolar hemodynamic response to hyperoxia and glucose in diabetic retinopathy, 699 
RGC abnormalities in Ins2Akita diabetic mice, 2635 
statin-mediated protection against diabetic retinopathy, 3131 
TEM7 in fibrovascular membranes in proliferative diabetic retinopathy, 3151 
Tie-2 in pericyte survival and recruitment in diabetic retinopathy, 2163 
VEGF polymorphisms and severity of diabetic retinopathy, 3611 
zeaxanthin effects on retinal metabolic abnormalities in diabetic rats, 1645 
Diadenosine polyphosphate recruits RhoA/ROCK and ERK1/2 in cornea, 4982 
Diet 
caffeine consumption and glaucoma risk, 1924 
lipofuscin pigments in RPE of abca4−/− mice after vitamin A supplementation, 3821 
lutein/zeaxanthin and omega-3 fatty acid supplementation in older adults, 3864 
omega-3 fatty acids and ganglion cell function, 3586 
protective effect of saffron supplement on retinal stress (rat), 1254 
Diurnal variation of axial length, IOP, and anterior eye biometrics, 2911 
DNA 
effect of superimposed electromagnetic noise on DNA damage of lens epithelial cells, 2009 
mitochondrial DNA oxidative damage in high glucose–induced human retinal endothelial cells, 4203 
mitochondrial oxidative DNA damage in EAU (rat), 3299 
mitomycin C–induced corneal endothelial DNA damage (goat), 4837 
Dopaminergic neurons, BDNF and survival of (guinea pig), 1282 
Dorzolamide 
effect on retinal oxygen tension in BRVO (pig), 1136 
effects of timolol-dorzolamide fixed combination vs. latanoprost on circadian diastolic ocular perfusion pressure in glaucoma, 4226 
Doxycycline, topical, induction of BDNF in RPE cells by (rat), 3631 
Driving 
effect of cognitive and vision loss on topography of attentional visual field, 4672 
glaucoma and fitness for, 2449 
glaucoma and on-road driving performance, 3035 
Drug delivery 
mucoadhesive microdiscs for, 4808 
pharmacokinetics after periocular drug administration, 320 
pharmacokinetics of intraocular drug delivery of Oregon Green–labeled triamcinolone by subtenon injection (rabbit), 4506 
to posterior intraocular tissues, 4712 
transscleral, effect of eye pigmentation on (rat), 333 
Drusen, macular vs. peripheral, in ARM, 1200 
Dry eye disease 
after LASIK, 168 
conjunctival and corneal sensitivity and, 2971 
diagnosis of, 1407 
induced by benzalkonium chloride in rabbits, 1850 
measuring higher-order aberrations after blinking in, 133 
murine model of, 1386 
rheology of tear film lipid layer in normal eyes and, 5319 
SPRR1B as biomarker for squamous metaplasia in, 34 
Dynamic contour tonometry, vs. intracameral IOP measurements, 2472 
E
Educational attainment and refraction, 534 
Elasticity and viscosity effects on hysteresis, 3919 
Elastin 
choroidal endothelial cell migration in AMD mediated by, 5574 
effect of TGF-β2 in human optic nerve astrocytes, 1464 
gene polymorphisms in neovascular AMD and polypoidal choroidal vasculopathy, 1101 
Electrical stimulation effects on BDNF induction in Müller cells, 4641 
Electrically invoked intrinsic signals in monkey retina, 2193 
Electromagnetic noise, effect on DNA damage of lens epithelial cells, 2009 
Electroretinography (ERG) 
cone ERG in ROP, 814 
cones in rhodopsin mutant P23H-3 retina (rat), 1116 
correlation between macular volume and focal macular ERG in RP, 3551 
correlation of photopic negative response with RNFL thickness and optic disc topography in glaucoma, 2201 
effect of methylprednisolone on RGCs and visual function after ocular ischemia (rat), 5003 
failure of Rpe65−/−/Nrl−/− mice to generate cone outer segments, 1126 (erratum, 1762) 
focal macular ERG in wet-type AMD, 3121 
inducible expression of Cre recombinase in RPE (mouse), 1248 
influence of quantitative trait locus on mouse chromosome 19 to cone ERG, 4058 
multifocal 
age-related changes in retinal functional topography, 5024 
long-term follow-up of RP patients with, 4664 
for prediction of local diabetic retinopathy over 3 years, 1622 
in rhodopsin P347L transgenic pigs, 2208 
murine model for lipid metabolism dysfunction, 1307 
ocular safety of intravitreal infliximab (rabbit), 1151 
phenotypic variation in enhanced S-cone syndrome, 2082 
photopic negative response of focal ERGs in glaucoma, 5636 
phototopic ERG from amacrine cell signaling in RCS rat retinal degeneration, 442 
protective effect of saffron supplement on retinal stress (rat), 1254 
quantification of ischemic damage in rat retina, 1056 
recovery of rod photoreceptors in ABCR-deficient mice, 2743 
retinal changes in early-onset cone–rod dystrophy (dog), 1106 
retinal dysfunction in patients with Stargardt disease and carrier relatives, 1191 
retinal effects of postnatal hyperoxia in neonatal rat, 458 
retinal function in Best macular dystrophy, 5553 
retinal response to repeated IOP challenge (rat), 3026 
rhodamine 6G toxicity in rat retina, 2120 
RNFL birefringence and thickness and ERG after optic nerve transection (monkey), 4444 
TNF-α in pathogenesis of Bacillus cereus endophthalmitis (mouse), 4482 
Endophthalmitis 
after cataract surgery, PCR for bacterial identification in, 1971 
Bacillus  
improving therapeutic regimens for, 1480 
TNF-α in pathogenesis of (mouse), 4482 
Klebsiella pneumoniae, hypermucoviscosity as virulence factor in (mouse), 4931 
Endoscopic vitrectomy in keratoprosthesis exchange (rabbit), 4407 
Endothelin-1, effect on fast axonal transport in rat optic nerve, 961 
Endothelium 
corneal 
blebbistatin prevention of inhibitory effects of thrombin on intercellular calcium wave propagation in, 4816 
intercellular adherent junctions expressed by, 3879 
mitomycin C–induced DNA damage in (goat), 4837 
role of carbonic anhydrase IV in function of, 1048 
toxic effects of rtPA on, 1392 
ubiquitination pathway for p27 degradation in, 189 
VIP in maintenance of corneal endothelial differentiation state, 3491 
elastin-mediated choroidal endothelial cell migration in AMD, 5574 
inhibition of pericyte loss and endothelial cell growth by aldose reductase inhibitor, 3216 
retinal 
advanced glycation impairment of vascular repair by endothelial progenitor cells, 1232 
cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in, 1242 
effect of curcumin on migration of, 3305 
mitochondrial DNA oxidative damage in high glucose–induced human retinal endothelial cells, 4203 
VEGF induction of MEF2C in, 3640 
Enhanced S-cone syndrome, phenotypic variation in, 2082 
Epi-LASIK. See also Laser in situ keratomileusis 
in vivo confocal microscopic evaluation of corneal wound healing after, 2416 
off-flap, for myopia, 2390 
Epidemiology 
anisometropia, amblyopia, and stereoacuity in school children with high prevalence of astigmatism, 4427 
antioxidants and cataract in North Indian population, 3328 
Barbados Eye Studies, impact of glaucoma, lens opacities, and cataract surgery on visual functioning and quality of life, 1333 
Chennai Glaucoma Study, neural rim characteristics of healthy South Indians, 3457 
complement factor H polymorphism and AMD in Chinese, 3312 
complement factor H polymorphism and AMD in Koreans, 2071 
Genes in Myopia Twin Study, adult-onset myopia, 3324 
Guangzhou Twin Eye Study 
heritability of anterior chamber depth in Chinese, 81 
heritability of central corneal thickness in Chinese, 4303 
heritability of iridotrabecular angle width in Chinese children, 1356 
heritability of optic disc and cup in Chinese, 1350 
shared genetic determinant of axial length, anterior chamber depth, and angle opening distance, 4790 
incidence of ophthalmic lymphoma in Denmark, 1980–2005, 3283 
Los Angeles Latino Eye Study, uncorrected refractive error in Latinos, 5264 
Multiethnic Study of Atherosclerosis, cardiovascular risk factors for retinal vein occlusion, 4297 
myopia and urban environment in Australian children, 3858 
prevalence and causes of functional low vision in Pakistan National Blindness and Visual Impairment Survey, 887 
prevalence and causes of functional low vision in school-age children, 877 
Rotterdam Study, cataract surgery and risk of aging macular disorders, 4795 
Salisbury Eye Evaluation Project, racial and other risk factors for AMD, 2395 
Shihpai Eye Study, prevalence and risk factors of AMD in elderly Chinese population, 3126 
Singapore Malay Eye Study 
prevalence and types of glaucoma in Malay people, 3846 
retinal vessel caliber, blood pressure, and cardiovascular risk factors in Asian population, 1784 
visual impairment, causes of vision loss, and falls, 528 (erratum, 1298) 
Sydney Childhood Eye Study 
ethnic variability in retinal vessel caliber, 1362 
OCT study of retinal and optic disc findings in adolescents, 4328 
10q26 gene cluster variants and AMD risk in Indian patients, 1771 
Timor-Leste vision-specific quality-of-life questionnaire, 4284 
visual impairment in school children in Brazil, 4308 
Xichang Pediatric Refractive Error Study 
spectacle acceptance among rural Chinese children, 2895 
visual function and myopia in rural Chinese children, 2888 
Epidermal growth factor (EGF), synergism with TGF-β1 in keratocyte differentiation, 2936 
Epiretinal prostheses, factors affecting perceptual thresholds in, 2303 
Epithelium 
conjunctival 
cannabinoid receptors in, 4535 
mediators of HSV-1 entry into, 4026 
regulation of TNFR1 in, 3992 
corneal 
β2-adrenergic receptor signaling–mediated wound repair in (mouse), 1857 
age-related changes in rat corneal epithelial nerve density, 910 
antiadhesive character of mucin O-glycans at apical surface of, 197 
corneal fibroblasts in differentiation of, 113 
delayed disruption of barrier function in cultured cells, 565 
effect of nonpreserved care solutions on 12 months of contact lens wear, 7 
protection from hypoxia-induced disruption of barrier function by KGF, 2432 
regulation of hyperosmolarity-induced cornification of, 539 
Rho/ROCK in regulation of cell cycle progression of, 175 
role of Rho in epithelial wound healing, 900 
serum- and feeder-cell–free culture of, 2438 
thickness changes due to CRTH rigid gas-permeable contact lenses, 3345 
GPR48 regulation of epithelial cell proliferation and migration during eyelid development (mouse), 4245 
lens 
cell cycle arrest by kynurenine in, 5466 
effect of superimposed electromagnetic noise on DNA damage of, 2009 
effect of thioltransferase deletion on cellular sensitivity to oxidative stress in (mouse), 4497 
interactions between TM cells and lens epithelial cells in infantile aphakic glaucoma, 3981 
iron regulates L-cystine uptake and glutathione levels in, 310 
limbal 
NFAT5 induction in hyperosmolar stressed cells, 1827 
squamous metaplasia of, 154 
OCTN1 and OCTN2 expression in ocular epithelium, 4844 
ocular surface, membrane-associated mucin release from, 1864 
retinal pigment (RPE) 
amyloid β accumulation and upregulation of angiogenic factors in ARPE19 cells, 2376 
anti-apoptotic role of αB-crystallin in RPE cells, 4753 
anti-inflammatory effects of AICAR in RPE cells, 1274 
antioxidant effect of quercetin in human RPE, 1712 
autologous partial thickness RPE-choroid transplantation (rabbit), 3185 
characterization of spontaneous mouse RPE cell line B6-RPE07, 3699 
connexin43-mediated protection of ARPE-19 cells, 800 
control of chemokine gradients by, 4620 
effects of benzo(e)pyrene on, 5111 
effects of RPE melanosomes on photosensitized and iron-mediated oxidation, 2838 
FKBP8 in RPE apoptosis, 1721 
inducible expression of Cre recombinase in (mouse), 1248 
iron regulates L-cystine uptake and glutathione levels in, 310 
light-induced retinal changes observed with high-resolution autofluorescence imaging of (macaque), 3715 
lipofuscin pigments in RPE of abca4−/− mice after vitamin A supplementation, 3821 
microperimetry after autologous RPE-choroid graft in macular dystrophy, 3143 
mitochondrial proteomics of RPE in AMD, 2848 
occludin regulation of permeability in, 2568 
P2Y receptor subtypes regulate calcium signaling in, 350 
PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in, 1671 
proteasome as target of oxidative damage in, 3622 
protection from membrane attack complex formation on murine RPE in AMD, 4126 
rabbit model of RPE transplantation, 4115 
regulated expression of caspase-12 gene in, 5593 
reprogramming progeny cells of embryonic chick RPE to produce photoreceptors, 4145 
rescue in RCS rats after late-stage RPE transplantation, 416 
restoration of lysosomal pH in RPE cells, 772 
serum-free culture of human prenatal RPE cells, 788 
sulforaphane protection of RPE cells against oxidative stress, 2606 
topical doxycycline induction of BDNF in (rat), 3631 
UBE2E3 required for proliferation of, 5611 
visual outcome after RPE–choroid translocation in AMD, 758 
Zip2 modulation of Nrf2-dependent antioxidant functions in, 1665 
Znt and ZIP zinc transporter expression in, 1221 (erratum, 3811) 
Errata, 527, 893, 1298, 1762, 2342, 2805, 3811 
Erythrocyte dynamics in retinal capillaries and choriocapillaris (monkey), 5510 
Erythropoietin protection of retinal cells in diabetes (rat), 732 
Esotropia 
duration of binocular decorrelation and latent nystagmus in strabismic monkeys, 1872 
infantile, timing of surgery for, 3432 
Estrogen, in regulation of meibomian gland gene expression (mouse), 1797 
Experimental autoimmune uveitis (EAU) 
clinical time-course of experimental autoimmune uveoretinitis (mouse), 5458 
gene expression in rats that are susceptible or resistant to, 1957 
mitochondrial oxidative DNA damage in (rat), 3299 
modulation of T cell responses by B subunit of E. coli heat-labile enterotoxin in (mouse), 4008 
new pathogenic epitopes of IRBP in (mouse), 1946 
reactivation of uveitogenic T cells by retinal astrocytes (mouse), 282 
regulatory T cells in (rat), 3999 
Extracellular matrix (ECM) 
artificial cornea construction from collagen–chondroitin sulfate foams and human cell cultures, 5325 
effects on substrate rigidity on TM cells, 262 
LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment, 4746 
podosome- or invadopodia-like structures for focal TM ECM turnover, 5353 
TGFβ-induced matrix contraction, 650 
Extracellular signal–regulated kinase (ERK) 
and caspase 1 in inflammation-induced inhibition of lacrimal gland protein secretion (mouse), 4392 
in conjunctival goblet cell proliferation, 3351 
diadenosine polyphosphate recruits RhoA/ROCK and ERK1/2 in cornea, 4982 
Extraocular muscles (EOMs) 
activated satellite cells in medial rectus muscles in strabismus, 215 
inflection in inactive lateral rectus muscle, 4858 
metabolic properties of rat oculorotatory EOMs, 4865 
myogenic growth factors decrease EOM force generation (rabbit), 221 
superior oblique palsy and torsional optokinetic nystagmus (monkey), 1421 
Eye-associated lymphoid tissue, local production of secretory IgA in, 2322 
Eye development and growth 
age-dependent control of lens growth by hypoxia, 1023 
AMPA receptor subunits in developing rabbit retina, 5619 
change in embryonic eye size and retinal cell proliferation after glycosaminoglycan injection (chick), 3289 
development of refractive status and ocular growth in C57BL/6 mice, 5208 
developmental changes in conjunctiva-associated lymphoid tissue (rabbit), 644 
differentiation and production of action potentials by embryonic rat retina stem cells, 5144 
effect of parental history of myopia on children’s eye size and growth, 873 
FoxE3 expression during lens fiber differentiation (mouse), 4269 
Gif1 mutation, lens development, and small-eye mouse phenotype, 1525 
GPR48 regulation of epithelial cell proliferation and migration during eyelid development (mouse), 4245 
HIF-1 as age-dependent regulator of lens cell proliferation (mouse), 4961 
identification of photoreceptor precursors in pars plana (mouse), 422 
induction of photoreceptor phenotype by exogenous Crx expression in mouse retinal stem cells, 429 
OA1 and Gαi3 in melanosomal biogenesis and optic pathway formation (mouse), 3245 
ocular growth and refractive error development in ROP, 5199 
reprogramming progeny cells of embryonic chick RPE to produce photoreceptors, 4145 
retinal Frizzled-5 in regulation of hyaloid vitreous vasculature development (mouse), 5561 
role of Acvr1 in lens development (mouse), 4953 
thyroid hormone required for cone opsin expression during retinal development (mouse), 2039 
thyroxine effects on embryonic chick corneal innervation, 139 
vascular precursors in developing human retina, 2178 
Eye movements 
duration of binocular decorrelation and latent nystagmus in strabismic monkeys, 1872 
effect of aging on torsional optokinetic nystagmus, 589 
effect of retinal prosthesis implant location on pursuit eye movements, 3933 
fMRI study of eye movement control in AMD, 1728 
Listing’s law in patients with skew deviation, 204 
relationship between upper lid saccades and pursuit, 2444 
saccade dynamics and saccadic adaptation, 604 
symmetry of look and stare optokinetic nystagmus, 581 
vertical pursuit in monkeys with acute superior oblique palsy, 3927 
Eyelid 
GPR48 regulation of epithelial cell proliferation and migration during development of (mouse), 4245 
relationship between upper lid saccades and pursuit, 2444 
F
Falls, vision loss and, 528 (erratum, 1298) 
Fc receptor, neonatal, mapping in rodent eye, 2025 
Feline herpesvirus, effects of λ-carrageenan on replication of (cat), 1496 
FGF-19, neuroprotective effects on adult photoreceptors, 1696 
FHL2 gene, role in angiogenesis (mouse), 5314 
Fiber cell beaded filament, lens structural stability and (mouse), 1030 
Fibrillin-1 and versican form hyaluronan-binding complex in ciliary body, 2870 
Fibroblasts 
corneal 
in differentiation of corneal epithelial cells, 113 
hypersensitive response to oxidative stress in keratoconus, 4361 
poly(I:C) in immunoinflammatory response in cultured, 3336 
lovastatin-inhibited myofibroblast transdifferentiation in Tenon fibroblasts, 3955 
pharmacologic activity of Physalis peruviana fruit juice on, 3074 
Fibrosis 
corneal, detection by imaging second harmonic–generated signals (rabbit), 4377 
intraocular, connective tissue growth factor as mediator of, 4078 
FIND-Eye Study, heritability of severity of diabetic retinopathy, 3839 
FK506-binding protein 51, regulation of nuclear transport of glucocorticoid receptor β by, 1037 
FKBP8 in RPE apoptosis, 1721 
Flash-evoked intrinsic signal imaging, to evaluate neural activity of RGCs in macaque retina, 4655 
Fluorescein angiography 
ATM gene variants in idiopathic perifoveal telangiectasia, 3806 
effect of dorzolamide on retinal oxygen tension in BRVO (pig), 1136 
Focal macular photopic negative response (monkey), 3544 
Fovea 
fine structure in ROP, 2061 
foveal cone–photoreceptor integrity in AMD, 2077 
relation of macular pigment to foveal architecture, 2134 
FOXC1-interacting protein p32, 5243 
FoxE3 expression during lens fiber differentiation (mouse), 4269 
Frequency-doubling technology, diagnostic accuracy of Matrix 24–2, N-30 frequency-doubling technology, and standard automated perimetry, 954 
Friedenwald Lecture 
Lois E. H. Smith, 2008 recipient of Friedenwald Award, 5175 
understanding retinopathy through ROP, 5177 
Frizzled-5 in regulation of hyaloid vitreous vasculature development (mouse), 5561 
FSCN2 gene, allelic copy number variation in, 3799 
Fuchs endothelial corneal dystrophy 
clusterin expression in, 2946 
peroxiredoxins in, 2946 
TCF8 in, 184 
Functional low vision 
prevalence and causes in Pakistan National Blindness and Visual Impairment Survey, 887 
prevalence and causes in school-age children, 877 
Fundus photography 
effect of dorzolamide on retinal oxygen tension in BRVO (pig), 1136 
imaging of mouse RGC death in vivo, 5546 
vs. OCT of retinal thickening in diabetic macular edema, 1745 
overlapping of retinal nerve fibers in horizontal plane, 1753 
phenotypic variation in enhanced S-cone syndrome, 2082 
Fundus reflectometry measurement of retinal lutein and zeaxanthin, 5568 
G
Ganglion cells, retinal (RGCs) 
abnormalities in Ins2Akita diabetic mice, 2635 
age-related losses of axons and, 4437 
antioxidant function of p53 in, 4237 
BDNF protection of ganglion cell morphology after optic nerve injury (cat), 2456 
effect of IL-1β on energy metabolism of R28 and RGC-5 retinal neurons, 5581 
effect of methylprednisolone after ocular ischemia (rat), 5003 
effects of LINGO-1 antagonists on RGC survival after ocular hypertension and optic nerve transection (rat), 975 
evaluating neural activity of RGCs in macaque retina, 4655 
14–3–3 proteins in regulation of bad trafficking in (rat), 2483 
imaging of mouse RGC death in vivo, 5546 
in vivo imaging of (macaque), 467 
longitudinal imaging of RGC damage with confocal scanning laser ophthalmoscopy, 4898 
omega-3 fatty acids and function of, 3586 
PI 3-kinase signaling in normal rat retinas and, 3687 
protective effects of thioredoxins 1 and 2 in RGCs after optic nerve transection (rat), 3535 
quantification of ischemic damage in rat retina, 1056 
quantification of retinal transneuronal degeneration in glaucoma, 1940 
rat AION induces RGC apoptosis, 3671 
ς-1 receptor neuroprotection in RGC-5 cells, 2577 
retinal microglia activation and optic nerve integrity with minocycline in murine glaucoma, 1437 
RGC protection by α2 modulation of NMDA receptor function (rat), 4515 
sigma-1 receptor regulation of voltage-gated calcium channels in, 4993 
statin modulation of HSP expression and RGC survival after retinal ischemia/reperfusion (rat), 4971 
system N glutamine transporters in, 5151 
Gene therapy, ocular 
delay of retinal degeneration in rd10 mouse by, 4278 
functional rescue of degenerating photoreceptors in Pde6bH620Q mice, 5067 
hyaluronic acid-chitosan nanoparticles for, 2016 
Gene transfer 
periocular triamcinolone enhances intraocular gene expression after adenoviral delivery (mouse), 399 
remodeling retinal neovascularization by ALK1 gene transfection, 4553 
synaptic pathology in retinoschisis knockout mouse retina and modification by, 3677 
Genes in Myopia Twin Study 
adult-onset myopia, 3324 
shared genes in refraction and axial length, 4336 
Genetics 
age-related cataract induced by targeted knockout of βB2-crystallin gene (mouse), 5476 
age-related cone abnormalities in zebrafish with genetic lesions in sonic hedgehog, 4631 
allelic copy number variation in FSCN2 gene, 3799 
association of CTLA-4 and IL-13 gene polymorphisms with Graves’ disease and ophthalmopathy in Chinese children, 2409 
association of LOXL1 common sequence variants in pseudoexfoliation syndrome, 1459 
ATM gene variants in idiopathic perifoveal telangiectasia, 3806 
autosomal recessive ocular albinism in Caucasian patients, 868 
B-RAF mutations in uveal melanoma, 23 
cataracts due to connexin50 mutants, 2549 
CCL2, CCR2, and TLR4 genes in AMD, 364 
CERKL mutations and associated phenotypes in autosomal recessive RP, 2709 
coagulation gene predictors of PDT for neovascular AMD, 3100 
complement factor H polymorphism in AMD 
in Chinese patients, 3312 
functional and structural implications of, 1763 
measurement in plasma using monoclonal antibodies, 1983 
neovascular AMD in Koreans, 2071 
10q26 gene cluster variants in AMD risk in Indian patients and, 1771 
dense nuclear cataract caused by γB-crystallin mutation (mouse), 304 
disease course of autosomal recessive RP patients with USH2A mutations, 5532 
duplication and divergence of zebrafish CRALBP genes, 3812 
early oncogenic mutations in GNAQ in uveal melanoma, 5230 
elastin gene polymorphisms in neovascular AMD and polypoidal choroidal vasculopathy, 1101 
estrogen and regulation in regulation of meibomian gland gene expression (mouse), 1797 
failure of Rpe65−/−/Nrl−/− mice to generate cone outer segments, 1126 (erratum, 1762) 
FIND-Eye Study, heritability of severity of diabetic retinopathy, 3839 
gene expression changes in porcine retinal detachment, 1262 
gene expression in rats that are susceptible or resistant to EAU, 1957 
gene expression of mouse corneal crystallin Aldh3a1, 1814 
gene expression profiles of human TM cells induced by triamcinolone and dexamethasone, 1886 
gene expression profiling in uveal melanoma, 4254 
gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy, 2613 
gene profiling of retinal detachment and reattachment (mouse), 511 
Genes in Myopia Personality Study, 882 
Genes in Myopia Twin Study 
adult-onset myopia, 3324 
dominant genetic effects on corneal astigmatism, 1339 
role of educational attainment in refraction, 534 
shared genes in refraction and axial length, 4336 
genetic modifiers of retinal degeneration in rd3 mouse, 2863 
genotype–phenotype correlations for exudative AMD, 3090 
Gif1 mutation, lens development, and small-eye mouse phenotype, 1525 
Guangzhou Twin Eye Study 
heritability of anterior chamber depth in Chinese, 81 
heritability of central corneal thickness in Chinese, 4303 
heritability of iridotrabecular angle width in Chinese children, 1356 
heritability of optic disc and cup in Chinese, 1350 
shared genetic determinant of axial length, anterior chamber depth, and angle opening distance, 4790 
GUCY2D mutations in autosomal dominant progressive cone degeneration, 5015 
heritability of optic disc parameters, 77 
HLA-Cw*0701 genotype and NK cell receptor AA haplotype in AMD, 5077 
IL-10 polymorphism in toxoplasmic retinochoroiditis, 1979 
IL13/IL-4R gene polymorphisms in Stevens-Johnson syndrome with ocular surface complications, 1809 
interleukin gene polymorphisms in AMD, 693 
intracellular aggregation of two cataract-associated γ-crystallin mutants, 3483 
KCNV2 mutations in cone dystrophy with supernormal rod responses, 751 
Klf4 target genes in mouse cornea, 3360 
LOXL1 polymorphisms and pseudoexfoliation in Japanese, 3976 
LOXL1 variants and primary open-angle glaucoma in three populations, 3465 
LOXL1 variations in primary open-angle and primary angle-closure glaucomas, 2343 
lysosome-related gene regulation in orbital fat in Graves’ ophthalmopathy, 4760 
new type of mutations in choroideremia, 1315 
NFI regulation of α6 integrin gene during corneal wound healing, 3758 
NOD2 in murine muramyl dipeptide–induced uveitis, 1518 
novel allele of Crybb2 in mouse and its expression in brain, 1533 
novel high myopia locus on 5p15, 3768 
novel rhodopsin mutation in autosomal dominant congenital stationary night blindness, 4105 
novel RPE65 hypomorphic mutation, 5235 
periocular triamcinolone enhances intraocular gene expression after adenoviral delivery (mouse), 399 
phenotypic variation in enhanced S-cone syndrome, 2082 
RASEF as tumor-suppressor gene in uveal melanoma, 1291 
regulated expression of caspase-12 gene in RPE, 5593 
retinal disease in Usher syndrome III due to clarin-1 mutations, 2651 
retinal dysfunction in patients with Stargardt disease and carrier relatives, 1191 
retinal structure in human RP caused by Rhodopsin mutations, 1580 
RLBP1 and CAIV mutations in Bothnia dystrophy, 3172 
RNA expression atlas of RP genes in human and mouse retina, 2330 
role of FHL2 gene in angiogenesis (mouse), 5314 
syndromic choroideremia, 4096 
TCF8 in Fuchs endothelial corneal dystrophy, 184 
TGIF as candidate gene for myopia, 49 
TLR4 gene polymorphisms and normal tension glaucoma, 4453 
Toll-like receptor polymorphisms and AMD, 1652 
Tyr43His mutant of human myocilin protein in glaucoma (mouse), 1932 
VEGF polymorphisms and severity of diabetic retinopathy, 3611 
WDR36 missense variants in glaucoma, 270 
Geographic atrophy 
associated with AMD, high-resolution spectral domain OCT in, 4137 
OCT of morphologic changes in, 3095 
Geranylgeranyltransferase I (GGTase-I), pharmacologic inhibition of GGTase-I and aqueous humor outflow, 2464 
Geriatric population. See also Age effects; Age-related macular degeneration 
effect of aging on retinal artery blood column diameter, 2094 
foveal cone–photoreceptor integrity in aging macula disorder, 2077 
lipoprotein-like particle accumulation in aging Bruch’s membrane, 2721 
local neuroretinal function during acute hypoxia in older people, 807 
lutein/zeaxanthin and omega-3 fatty acid supplementation in older adults, 3864 
motion-detection threshold and measures of balance in, 5257 
prevalence and risk factors of AMD in elderly Chinese population, 3126 
racial and other risk factors for AMD, 2395 
visual function and quality of life in elderly women with cataracts, 1 
Gif1 mutation, lens development, and small-eye mouse phenotype, 1525 
Glaucoma. See also Ocular hypertension 
analysis of atypical SLP patterns by polarization-sensitive OCT, 5366 
angiopoietin-like 7 protein and, 3438 
Bayesian machine learning classifiers for combining structural and functional measurements in, 945 
Chennai Glaucoma Study, neural rim characteristics of healthy South Indians, 3457 
5-chlorouracil delivery using poly(ortho esters) in filtering surgery for (rabbit), 2993 
comparison of anterior segment structures in two rat models of, 2478 
comparison of HRT reference planes, 3970 
contrast sensitivity perimetry test in, 3049 
corneal hysteresis and optic nerve surface compliance in, 3262 
correlation of photopic negative response with RNFL thickness and optic disc topography in, 2201 
diagnostic accuracy of Matrix 24–2, N-30 frequency-doubling technology, and standard automated perimetry, 954 
effects of timolol-dorzolamide fixed combination vs. latanoprost on circadian diastolic ocular perfusion pressure in, 4226 
fitness to drive and, 2449 
HRT-3 Glaucoma Probability Score vs. stereophotography for prediction of glaucoma progression, 1898 
human Müller stem cell transplantation in (rat), 3449 
impact of diabetic retinopathy on quantitative RNFL measurement and glaucoma screening, 687 
impact of glaucoma, lens opacities, and cataract surgery on visual functioning and quality of life, 1333 
interactions between TM cells and lens epithelial cells in infantile aphakic glaucoma, 3981 
IOP elevation and glaucomatous changes in mice, 613 
manganese-enhanced MRI of DBA/2J mouse model of hereditary glaucoma, 5083 
mapping standard automated perimetry to RNFL in, 3018 
mitochondrial defects and dysfunction in calcium regulation in glaucomatous TM cells, 4912 
mitochondrial OPA1 release in glaucomatous optic nerve (mouse), 4903 
normal tension 
intracranial pressure in, 5412 
TLR4 gene polymorphisms and, 4453 
on-road driving performance and, 3035 
open-angle 
caffeine consumption and, 1924 
estimating rate of progressive visual field damage in, 66 
estimation of ocular rigidity in, 4046 
intracranial pressure in, 5412 
LOXL1 variants in three populations, 3465 
LOXL1 variations in, 2343 
mitochondrial complex I defect in TM cells in, 1447 
nitrotyrosine expression and oxidative consequences in TM of patients with, 2506 
screening tests for, 5373 
in vivo confocal microscopy of conjunctival modifications in, 3042 
open-angle (OAG), prostaglandin analogue reduction of oxidative stress in TM, 4872 
photopic negative response of focal ERGs in, 5636 
prevalence and types in Malay people, 3846 
primary angle-closure, LOXL1 variations in, 2343 
pseudoexfoliation, association of LOXL1 common sequence variants in, 1459 
quality of life and priorities of patients with, 1907 
quantification of retinal transneuronal degeneration in, 1940 
reliability of ocular response analyzer, 968 
retinal microglia activation and optic nerve integrity with minocycline in (mouse), 1437 
retinal vascular narrowing in Asian eyes with, 5397 
RGC protection by α2 modulation of NMDA receptor function in (rat), 4515 
risk after pediatric cataract surgery, 1791 (erratum, 2805) 
serum amyloid A in, 1916 
standard reference height variability and its influence on HRT3 parameters, 4881 
tissue transglutaminase expression in glaucomatous trabecular tissue, 622 
Tyr43His mutant of human myocilin protein in (mouse), 1932 
WDR36 missense variants in, 270 
Glial fibrillary acidic protein (GFAP), abnormal reactivity of Müller cells after retinal detachment in mice deficient in vimentin and, 3659 
Glucocorticoid receptor β, FK506-binding protein 51 regulation of nuclear transport of, 1037 
Glucosamine inhibition of endotoxin-induced uveitis (rat), 5441 
Glucose 
measurement of glucose utilization in cone-dominant ground squirrel retina, 4613 
retinal arteriolar hemodynamic response to hyperoxia and glucose in diabetic retinopathy, 699 
Glucose-6-phosphate dehydrogenase deficiency, in NAION, 1328 
Glutamate receptors 
AMPA receptor subunits in developing rabbit retina, 5619 
cell communication mechanisms in vertebrate retina (Proctor Lecture), 5184 
RGC protection by α2 modulation of NMDA receptor function (rat), 4515 
Glutamine transporters in RGCs, 5151 
Glutathione 
hypothesis for outer segment renewal in photoreceptor cells (perspectives), 3259 
protection against apoptosis by exogenous glutathione in Leber hereditary optic neuropathy, 671 
Glycated albumin inhibitor, amelioration of vitreous abnormalities in diabetes by (rat), 5089 
Glycosaminoglycans 
biosynthesis and outflow facility in perfusion culture, 2495 
change in embryonic eye size and retinal cell proliferation after injection of (chick), 3289 
GNAQ mutations in uveal melanoma, 5230 
Goblet cells, ERK in proliferation of, 3351 
GPR48, regulation of epithelial cell proliferation and migration during eyelid development (mouse), 4245 
Granulocyte colony-stimulating factor (G-CSF), protection of photoreceptors against light-induced damage by (mouse), 5629 
Graves’ ophthalmopathy 
association of CTLA-4 and IL-13 gene polymorphisms with Graves’ disease and ophthalmopathy in Chinese children, 2409 
lysosome-related gene regulation in orbital fat in, 4760 
Gross Motor Function Classification System, visual sensory and motor deficits in children with cerebral palsy, 572 
Guangzhou Twin Eye Study 
heritability of anterior chamber depth in Chinese, 81 
heritability of central corneal thickness in Chinese, 4303 
heritability of iridotrabecular angle width in Chinese children, 1356 
heritability of optic disc and cup in Chinese, 1350 
shared genetic determinant of axial length, anterior chamber depth, and angle opening distance, 4790 
GUCY2D mutations in autosomal dominant progressive cone degeneration, 5015 
Guyton, David L., 2007 recipient of the Weisenfeld Award, 846 
H
Heat shock proteins (HSP) 
AIPL1 association with Hsp 90 and Hsp70, 2878 
HSP90 inhibition in uveal melanoma cells, 2348 
oxidative stress and TGF-β2–induced HSP27 expression in optic nerve head astrocytes, 5403 
statin modulation of HSP expression and RGC survival after retinal ischemia/reperfusion (rat), 4971 
Heidelberg Retina Tomograph (HRT) 
comparison of HRT reference planes, 3970 
heritability of optic disc and cup in Chinese, 1350 
HRT-3 Glaucoma Probability Score vs. stereophotography for prediction of glaucoma progression, 1898 
standard reference height variability and its influence on HRT3 parameters, 4881 
Heme oxygenase-1, in corneal wound healing (mouse), 3379 
Hemodynamics 
effect of plasmapheresis on hyperviscosity-related retinopathy and retinal hemodynamics in Waldenström’s macroglobulinemia, 1157 
indomethacin effect on retinal and choroidal blood flow, 1065 
Hemorrhage 
perinatal, AMD-like lesions in rat retina after, 2790 
predicting vitreous hemorrhage clearance after Vitrase injection in diabetic patients, 4219 
subretinal, protective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in (rabbit), 4071 
Heparan sulfate, change in embryonic eye size and retinal cell proliferation after glycosaminoglycan injection (chick), 3289 
Heparin, change in embryonic eye size and retinal cell proliferation after glycosaminoglycan injection (chick), 3289 
Herpes simplex virus (HSV) 
apolipoprotein E mimetic peptide treatment of ocular herpetic stromal keratitis (mouse), 4263 
leukocytes in HSV-infected corneas without herpes stromal keratitis (mouse), 1488 
mediators of HSV-1 entry into conjunctival epithelium, 4026 
neutrophil protection of retina in HSV-1–injected eye (mouse), 4018 
non-mitogenic anti-CD3F(ab′)2 monoclonal antibody for herpetic stromal keratitis (mouse), 5425 
HIF-1 as age-dependent regulator of lens cell proliferation (mouse), 4961 
HIF-2α haploinsufficiency and oxygen-induced retinopathy-associated neovascularization (mouse), 2714 
Higher-order aberrations, ocular 
measuring after blinking in dry eye, 133 
time course of changes in ocular higher-order aberrations and contrast sensitivity after overnight orthokeratology, 4314 
Histology 
autoimmune optic neuritis in Marmoset monkeys, 3707 
clinical time-course of experimental autoimmune uveoretinitis (mouse), 5458 
corneal wound healing in osteopontin-deficient mouse, 1367 
effect of amniotic membrane transplantation on healing of bacterial keratitis (rat), 163 
effects of photocoagulation on intraretinal PO2 (cat), 380 
Gif1 mutation, lens development, and small-eye mouse phenotype, 1525 
human tissue–engineered model of corneal wound healing, 1376 
N-(4-hydroxyphenyl) retinamide and choroidal neovascularization (mouse), 1210 
ischemic tolerance in rat retina induced by lipopolysaccharide, 4604 
local production of secretory IgA in eye-associated lymphoid tissue, 2322 
morphometric analysis of human peripapillary RNFL thickness, 941 
murine model of dry eye, 1386 
naloxone neuroprotection against light-induced photoreceptor degeneration (rat), 2589 
ocular safety of intravitreal infliximab (rabbit), 1151 
ophthalmic lymphoma, 3283 
polypoidal choroidal vasculopathy, 4729 
primate model of NAION, 2985 
PRK with solid state laser 213 nm and excimer laser 193 mn, 1415 
quantification of ischemic damage in rat retina, 1056 
rabbit dry eye induced by benzalkonium chloride, 1850 
rhodamine 6G toxicity in rat retina, 2120 
Stat6-independent inflammation of IκBζ−/− mice, 3387 
TNF-α in pathogenesis of Bacillus cereus endophthalmitis (mouse), 4482 
Zeb1 mutant mouse model of posterior corneal dystrophy, 1843 
Homonymous hemianopias, Humphrey Matrix detection of, 924 
HTRA1 gene variants 
AMD, CFH, smoking and, 2357 
in Chinese patients with polypoidal choroidal vasculopathy, 2613 
Human leukocyte antigens (HLA) 
HLA-Cw*0701 genotype and NK cell receptor AA haplotype in AMD, 5077 
monosomy of chromosome 3 and inflammatory phenotype in uveal melanoma, 505 
Humphrey Matrix perimetry 
in detection of homonymous hemianopias, 924 
diagnostic accuracy of Matrix 24–2, N-30 frequency-doubling technology, and standard automated perimetry, 954 
in optic nerve and chiasmal disorders, 917 
Hyaluronan, versican and fibrillin-1 form hyaluronan-binding complex in ciliary body, 2870 
Hyaluronic acid-chitosan nanoparticles for ocular gene therapy, 2016 
Hyaluronidase, predicting vitreous hemorrhage clearance after Vitrase injection in diabetic patients, 4219 
N-(4-Hydroxyphenyl) retinamide, and choroidal neovascularization (mouse), 1210 
Hyperbaric oxygen, selective degeneration of central photoreceptors after (mouse), 3207 
Hypercarbia, retinal arteriolar and middle cerebral artery responses to hypercarbic/hyperoxic stimuli, 5503 
Hyperopia, astigmatism in experimental myopia or hyperopia (chicken), 858 
Hyperosmolarity-induced cornification of corneal epithelial cells, 539 
Hyperoxia 
NO in regulation of retinal blood flow in response to (cat), 4595 
Oxr1 in hyperoxia-challenged mouse retina, 4561 
postnatal, retinal effects in neonatal rat, 458 
retinal arteriolar and middle cerebral artery responses to hypercarbic/hyperoxic stimuli, 5503 
retinal arteriolar hemodynamic response to hyperoxia and glucose in diabetic retinopathy, 699 
Hypersensitivity reactions 
to oxidative stress in keratoconus corneal fibroblasts, 4361 
transcriptional analyses after CCR3 blockade of, in experimental allergic conjunctivitis (mouse), 5307 
Hyperviscosity-related retinopathy and retinal hemodynamics in Waldenström’s macroglobulinemia, effect of plasmapheresis on, 1157 
Hypoxia 
age-dependent control of lens growth by, 1023 
cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells, 1242 
effect of mild hypoxia on chromatic sensitivity, 820 
HIF-1 as age-dependent regulator of lens cell proliferation (mouse), 4961 
KGF protection of corneal epithelial cells from hypoxia-induced disruption of barrier function, 2432 
local neuroretinal function during acute hypoxia in older people, 807 
regulation of PEDF by Müller cells under, 5161 
targeting as novel treatment for retinoblastoma (mouse), 2799 
Hysteresis, biomechanical model of effect of viscosity and elasticity on, 3919 
I
Idiopathic macular telangiectasia, type 2, confocal blue reflectance in, 1172 
Idiopathic perifoveal telangiectasia 
ATM gene variants in, 3806 
quantitative OCT analysis of, 2156 
IκB kinase-2 (IKK-2) inhibitor, inhibition of collagen degradation by, 4850 
Immune function 
complement-associated deposits in retina, 743 
degradation of secretory IgA in tears in P. aeruginosa keratitis, 4939 
dysfunction of CD4+CD25high regulatory T cells in Vogt-Koyanagi-Harada syndrome, 3475 
gene expression changes in porcine retinal detachment, 1262 
HLA-Cw*0701 genotype and NK cell receptor AA haplotype in AMD, 5077 
lack of IFN-γ synthesis in aqueous humor during corneal graft rejection and suppressed NO production by macrophages (rat), 4923 
local production of secretory IgA in eye-associated lymphoid tissue, 2322 
modulation of T cell responses by B subunit of E. coli heat-labile enterotoxin in EAU (mouse), 4008 
neutrophil protection of retina in HSV-1–injected eye (mouse), 4018 
protective effects of CD1d-reactive invariant NK cells in corneal inflammation (mouse), 105 
reactivation of uveitogenic T cells by retinal astrocytes (mouse), 282 
regulatory T cells in EAU (rat), 3999 
suppression of ocular surface inflammation by expanded regulatory T cells (mouse), 5434 
Immunocytochemistry 
clusterin expression in Fuchs endothelial corneal dystrophy, 2946 
fiber cell beaded filament and lens structural stability (mouse), 1030 
localization of keratan sulfate proteoglycans, 2424 
NFAT5 induction in hyperosmolar stressed limbal epithelial cells, 1827 
RhoA/ROCK and ERK1/2 in cornea, 4982 
Znt and ZIP zinc transporter expression in RPE, 1221 (erratum, 3811) 
Immunohistochemistry 
α-aminoadipate induces progenitor cell properties of Müller glia (mouse), 1142 
artificial cornea construction from collagen–chondroitin sulfate foams and human cell cultures, 5325 
cannabinoid receptors in conjunctival epithelium, 4535 
choroidal vessel abnormalities in mice lacking TIMP-3, 2813 
collagen distribution in human vitreoretinal interface, 4089 
complement-associated deposits in retina, 743 
cones in rhodopsin mutant P23H-3 retina (rat), 1116 
connective tissue growth factor as mediator of intraocular fibrosis, 4078 
CXCL8, CLCR1, and CXCR2 expression in human and rabbit retina, 4578 
dense nuclear cataract caused by γB-crystallin mutation (mouse), 304 
effects of anti–VEGF-A monoclonal antibody on murine choroidal neovascularization, 1178 
effects of bevacizumab on retinal cells in organotypic culture, 3164 
erythropoietin protection of retinal cells in diabetes (rat), 732 
failure of Rpe65−/−/Nrl−/− mice to generate cone outer segments, 1126 (erratum, 1762) 
gene expression of mouse corneal crystallin Aldh3a1, 1814 
imbalance in cysteine proteinase cathepsins and cystatin C in rd1 mouse retina, 1089 
LYVE-1-positive macrophages in human choroid, 5222 
mapping of neonatal Fc receptor in rodent eye, 2025 
MMP-2 expression in melanoma-associated spongiform scleropathy, 2806 
naloxone neuroprotection against light-induced photoreceptor degeneration (rat), 2589 
OCTN1 and OCTN2 expression in ocular epithelium, 4844 
osteopontin expression in rat retina after injury, 762 
proteomic analysis of climatic keratopathy droplets, 2829 
retinal changes in early-onset cone–rod dystrophy (dog), 1106 
retinal VLDLR expression and neovascularization in knockout mouse model of retinal angiomatous proliferation, 407 
role of P2X7 in cornea (mouse), 4384 
time-dependent effects of elevated IOP on optic nerve head axonal transport (pig), 986 
Tyr43His mutant of human myocilin protein in glaucoma (mouse), 1932 
UV radiation and MMPs in ocular surface squamous neoplasia, 5295 
vascular precursors in developing human retina, 2178 
Indocyanine green (ICG), light-induced decomposition of, 1777 
Indomethacin, effect on retinal and choroidal blood flow, 1065 
Infantile nystagmus syndrome 
oscillopsia in, 3424 
stress effects in, 2977 
wavelet analysis in, 3413 
Infants. See also Pediatric population 
preterm 
computerized analysis of retinal vessel width and tortuosity in, 3577 
IOP in, 87 
ocular biometry in, 453 
timing of surgery for infantile esotropia, 3432 
Infection 
antimicrobial efficacy of riboflavin/UVA combination treatment, 3402 
apolipoprotein E mimetic peptide treatment of ocular herpetic stromal keratitis (mouse), 4263 
defensin beta-109 expression on ocular surface in, 28 
degradation of secretory IgA in tears in P. aeruginosa keratitis, 4939 
effect of amniotic membrane transplantation on healing of bacterial keratitis (rat), 163 
effects of λ-carrageenan on replication of feline herpesvirus (cat), 1496 
effects of lipid raft disruption in Pseudomonas aeruginosa keratitis (mouse), 1000 
endotoxin as cause of leptospiral uveitis, 5419 
hypermucoviscosity as virulence factor in Klebsiella pneumoniae endophthalmitis (mouse), 4931 
IL-10 polymorphism in toxoplasmic retinochoroiditis, 1979 
improving therapeutic regimens for Bacillus endophthalmitis, 1480 
inhibition of Acanthamoeba-induced cytopathic effect by milk proteins, 1010 
leukocytes in HSV-infected corneas without herpes stromal keratitis (mouse), 1488 
mediators of HSV-1 entry into conjunctival epithelium, 4026 
murine CMV infection and apoptosis in retinal cultures, 295 
neutrophil protection of retina in HSV-1–injected eye (mouse), 4018 
non-mitogenic anti-CD3F(ab′)2 monoclonal antibody for herpetic stromal keratitis (mouse), 5425 
passive immunization against S. pneumoniae keratitis (rabbit), 290 
PCR for bacterial identification in postcataract surgery endophthalmitis, 1971 
substance P promotes susceptibility to Pseudomonas aeruginosa keratitis (mouse), 1502 
Inflammation 
anti-crystallin seroreactivity in uveitis, 4476 
anti-inflammatory effects of AICAR in RPE cells, 1274 
defensin beta-109 expression on ocular surface in, 28 
dexamethasone inhibition of inflammatory and angiogenic mediators, 2030 
gene expression changes in porcine retinal detachment, 1262 
mechanisms of murine lacrimal gland repair after, 4399 
mediation of cannabidiol anti-inflammation in retina by equilibrative nucleoside transporter and A2A adenosine receptor (rat), 5526 
monosomy of chromosome 3 and inflammatory phenotype in uveal melanoma, 505 
poly(I:C) in immunoinflammatory response in cultured corneal fibroblasts, 3336 
protective effects of CD1d-reactive invariant NK cells in corneal inflammation (mouse), 105 
Stat6-independent inflammation of Iκβζ−/− mice, 3387 
suppression of ocular surface inflammation by expanded regulatory T cells (mouse), 5434 
Infliximab, intravitreal, ocular safety of (rabbit), 1151 
Insulin growth factor 1, in ROP (Friedenwald Lecture), 5177 
Insulin growth factor 1 receptor (IGF-1R), signaling in rod outer segments, 4765 
Integrins 
NFI regulation of α6 integrin gene during corneal wound healing, 3758 
retinal pathology in α1 integrin-null mice, 4647 
Interferons, lack of IFN-γ synthesis in aqueous humor during corneal graft rejection and suppressed NO production by macrophages (rat), 4923 
Interleukins (IL) 
association of CTLA-4 and IL-13 gene polymorphisms with Graves’ disease and ophthalmopathy in Chinese children, 2409 
effect of IL-1β on energy metabolism of R28 and RGC-5 retinal neurons, 5581 
IL-6 as photoreceptor neuroprotectant in experimental retinal detachment (mouse, rat), 3193 
IL-10 polymorphism in toxoplasmic retinochoroiditis, 1979 
Il-23 and IL-17 in Behçet disease with active uveitis, 3058 
IL13/IL-4R gene polymorphisms in Stevens-Johnson syndrome with ocular surface complications, 1809 
neutrophil chemotaxis and IL-10 expression in tolerance of endotoxin-induced uveitis (rat), 5450 
TRPV1 modulation of IL-6 and NFκB with pressure (mouse), 3004 
Interphotoreceptor retinoid binding protein (IRBP), new pathogenic epitopes in EAU (mouse), 1946 
Intracranial pressure, in glaucoma and ocular hypertension, 5412 
Intraocular pressure (IOP). See also Glaucoma; Ocular hypertension 
α-2 adrenergic receptor subtypes and diurnal IOP variation (mouse), 929 
bestrophin-2 in generation of, 1563 
CPAP-related IOP increase in obstructive sleep apnea, 934 
diurnal variation of axial length, IOP, and anterior eye biometrics, 2911 
dynamic contour tonometry vs. intracameral IOP measurements, 2472 
effects of cyclic IOP on conventional outflow facility, 275 
effects of timolol-dorzolamide fixed combination vs. latanoprost on circadian diastolic ocular perfusion pressure in glaucoma, 4226 
hydrodynamic and morphologic changes in aqueous humor outflow pathway after IOP elevation (cow), 5346 
influences of atmospheric pressure and temperature on, 5392 
IOP elevation and glaucomatous changes in mice, 613 
IOP reduction by angiotensin (1–7) (rabbit), 2557 
in preterm infants, 87 
reliability of ocular response analyzer, 968 
retinal response to repeated IOP challenge (rat), 3026 
serum amyloid A effect on, 1916 
time-dependent effects of elevated IOP on optic nerve head axonal transport (pig), 986 
Iridocorneal angle, imaging technique for anterior and posterior segments (mouse), 5168 
Iridotrabecular angle width, heritability in Chinese children, 1356 
Iron 
effects of RPE melanosomes on photosensitized and iron-mediated oxidation, 2838 
regulation of L-cystine uptake and glutathione levels, 310 
Ischemia 
deleterious role of TNF-α in retinal ischemia–reperfusion injury, 3605 
effect of methylprednisolone on RGCs and visual function after ocular ischemia (rat), 5003 
ischemic tolerance in rat retina induced by lipopolysaccharide, 4604 
MCP-1 deficiency and retinal neovascularization in murine ischemic retinopathy, 4195 
quantification of ischemic damage in rat retina, 1056 
somatostatin protection against retinal ischemia (rat), 342 
statin modulation of HSP expression and RGC survival after retinal ischemia/reperfusion (rat), 4971 
J
JNK-paxillin signaling pathway in corneal epithelial cell wound healing, 125 
K
KCNV2 mutations in cone dystrophy with supernormal rod responses, 751 
Keratan sulfate proteoglycans, immunochemical localization of, 2424 
Keratectomy, photorefractive (PRK), with solid state laser 213 nm and excimer laser 193 mn, 1415 
Keratinocyte growth factor (KGF), protection of corneal epithelial cells from hypoxia-induced disruption of barrier function by, 2432 
Keratitis 
bacterial, effect of amniotic membrane transplantation on healing of (rat), 163 
herpetic stromal 
apolipoprotein E mimetic peptide treatment of (mouse), 4263 
non-mitogenic anti-CD3F(ab′)2 monoclonal antibody (mouse), 5425 
inhibition of Acanthamoeba-induced cytopathic effect by milk proteins, 1010 
Pseudomonas aeruginosa  
degradation of secretory IgA in tears in, 4939 
effects of lipid raft disruption in (mouse), 1000 
substance P promotes susceptibility to (mouse), 1502 
substance P–induced delay in apoptosis after (mouse), 4458 
S. pneumoniae, passive immunization against (rabbit), 290 
Keratoconus 
hypersensitive response to oxidative stress in keratoconus corneal fibroblasts, 4361 
in vivo confocal microscopy in, 2964 
posterior corneal aberrations in, 5645 
Keratocytes, EGF synergism with TGF-β1 in differentiation of, 2936 
Keratoprosthesis exchange, endoscopic vitrectomy in (rabbit), 4407 
Klebsiella pneumoniae endophthalmitis, hypermucoviscosity as virulence factor in (mouse), 4931 
Klf4 target genes in mouse cornea, 3360 
Kynurenine, cell cycle arrest in lens epithelial cells by, 5466 
L
Lacrimal gland 
caspase 1 and ERK in inflammation-induced inhibition of lacrimal gland protein secretion (mouse), 4392 
chloride channels and acinar cell volume in (rabbit), 5517 
mechanisms of murine lacrimal gland repair, 4399 
secretoglobins in (rabbit), 2856 
Laser in situ keratomileusis (LASIK) 
chronic dry eye after, 168 
corneal vertex vs. central pupil references with aberration-free ablation and LASIK, 5287 
in vivo confocal microscopic evaluation of corneal wound healing after Epi-Lasik, 2416 
off-flap Epi-LASIK for myopia, 2390 
Laser technology 
effects of photocoagulation on intraretinal PO2 (cat), 380 
estimation of ocular rigidity in primary open-angle glaucoma, 4046 
in vivo response of phagocytes to laser-induced fundus damage (mouse), 3649 
intratissue refractive index shaping of cornea and lens (cat), 5332 
PRK with solid state laser 213 nm and excimer laser 193 mn, 1415 
real-time in vivo imaging of retinal cell apoptosis after laser exposure (rat), 2773 
Latanoprost 
effects of timolol-dorzolamide fixed combination vs. latanoprost on circadian diastolic ocular perfusion pressure in glaucoma, 4226 
induction of collagen gel contraction by, 1429 
Leber congenital amaurosis 
due to RPE65 mutations, photoreceptor layer topography in children with, 4573 
protein AIPL1 as part of chaperone heterocomplex, 2878 
Rpe65−/− and Lrat−/− murine models of, 2384 
Leber hereditary optic neuropathy, protection against apoptosis by exogenous glutathione in, 671 
Lens of eye 
age-dependent control of lens growth by hypoxia, 1023 
age-related cataract induced by targeted knockout of βB2-crystallin gene (mouse), 5476 
antioxidants and cataract in North Indian population, 3328 
binocular lens tilt and decentration measurements in phakic eyes, 2216 
cataracts due to connexin50 mutants, 2549 
cell cycle arrest by kynurenine in lens epithelial cells, 5466 
ciliary body forward accommodative movement facilitated by zonular attachments to lens capsule (monkey), 5495 
corneal curvature and axial length in children with congenital/infantile cataract, 4774 
dense nuclear cataract caused by γB-crystallin mutation (mouse), 304 
downregulation of MMP-2 and -9 by proteasome inhibition and lens epithelial cell migration, 1998 
effect of superimposed electromagnetic noise on DNA damage of lens epithelial cells, 2009 
effect of surgical intervention on lens and ciliary body function in monkeys, 5484 
effect of thioltransferase deletion on cellular sensitivity to oxidative stress in lens epithelial cells (mouse), 4497 
fiber cell beaded filament and lens structural stability (mouse), 1030 
FoxE3 expression during lens fiber differentiation (mouse), 4269 
free and bound water in normal and cataractous lenses, 1991 
Gif1 mutation, lens development, and small-eye mouse phenotype, 1525 
HIF-1 as age-dependent regulator of lens cell proliferation (mouse), 4961 
identification of lens fiber connexin posttranslational modifications, 1553 
impact of glaucoma, lens opacities, and cataract surgery on visual functioning and quality of life, 1333 
inhibition of crystallin ascorbylation in mouse model of lenticular aging, 4945 
interactions between TM cells and lens epithelial cells in infantile aphakic glaucoma, 3981 
intratissue refractive index shaping of cornea and lens (cat), 5332 
iron regulates L-cystine uptake and glutathione levels in, 310 
optical power of isolated human crystalline lens, 2541 
refractive index distribution changes with age and accommodation, 2531 
role of Acvr1 in lens development (mouse), 4953 
role of lens capsule on mechanical accommodative response in a lens stretcher, 4490 
susceptibility of ovine lens crystallins to proteolytic cleavage in hereditary cataract, 1016 
visual function and quality of life in elderly women with cataract, 1 
Leptospiral uveitis, endotoxin as cause of, 5419 
Leukocytes 
effects of triamcinolone acetonide on leukocyte dynamics in rat retinal microcirculation, 2127 
in HSV-infected corneas without herpes stromal keratitis (mouse), 1488 
Light exposure 
decomposition of indocyanine green induced by, 1777 
G-CSF protection of photoreceptors against light-induced damage (mouse), 5629 
light-induced retinal changes observed with high-resolution autofluorescence imaging of RPE (macaque), 3715 
Müller cell response to blue light injury of rat retina, 3559 
naloxone neuroprotection against light-induced photoreceptor degeneration (rat), 2589 
protective effect of saffron supplement on retinal stress (rat), 1254 
Limbal epithelial cells 
cornea limbal stem/progenitor cell transfection in organ culture model, 3395 
corneal wound healing independent of limbal stem cell influence, 5279 
NFAT5 induction in hyperosmolar stressed cells, 1827 
squamous metaplasia of, 154 
Limbus 
immunochemical localization of keratan sulfate proteoglycans in, 2424 
separation of two populations of mouse limbal stem cells, 3903 
LINGO-1 antagonists, effects on RGC survival after ocular hypertension and optic nerve transection (rat), 975 
Lipid raft disruption in Pseudomonas aeruginosa keratitis (mouse), 1000 
Lipids and lipoproteins 
intraretinal leakage and LDL oxidation in diabetic retinopathy, 2679 
lipid composition of human meibum and tears, 3779 
lipoprotein-like particle accumulation in aging Bruch’s membrane, 2721 
murine model for lipid metabolism dysfunction, 1307 
retinal VLDLR expression and neovascularization in knockout mouse model of retinal angiomatous proliferation, 407 
Lipofuscin pigments in RPE of abca4−/− mice after vitamin A supplementation, 3821 
Lipopolysaccharide 
endotoxin as cause of leptospiral uveitis, 5419 
glucosamine inhibition of endotoxin-induced uveitis (rat), 5441 
ischemic tolerance in rat retina induced by, 4604 
neutrophil chemotaxis and IL-10 expression in tolerance of endotoxin-induced uveitis (rat), 5450 
Listing’s law in patients with skew deviation, 204 
Los Angeles Latino Eye Study, uncorrected refractive error in Latinos, 5264 
Lovastatin-inhibited myofibroblast transdifferentiation in Tenon fibroblasts, 3955 
LOXL1 
choroidal neovascularization in LOXL1-deficient mice, 2599 
common LOXL1 sequence variants in pseudoexfoliation syndrome, 1459 
gene variants and primary open-angle glaucoma in three populations, 3465 
gene variants in primary open-angle and primary angle-closure glaucomas, 2343 
LOXL1 polymorphisms and pseudoexfoliation in Japanese, 3976 
Lutein 
fundus reflectometry measurement of retinal zeaxanthin and, 5568 
lutein/zeaxanthin and omega-3 fatty acid supplementation in older adults, 3864 
Lymphatic drainage, orbital, of radiolabeled colloids (rabbit), 2563 
Lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)–positive macrophages in human choroid, 5222 
Lymphoma 
efficacy of intravitreal and intracerebral rituximab injections in (mice), 4738 
ophthalmic, incidence in Denmark, 1980–2005, 3283 
Lysosomes 
lysosome-related gene regulation in orbital fat in Graves’ ophthalmopathy, 4760 
oxidative stress-induced alterations in lysosomal function in porcine TM cells, 3961 
restoration of lysosomal pH in RPE cells, 772 
Lysyl oxidase (LOX), in proliferative diabetic retinopathy and rhegmatogenous retinal detachment, 4746 
M
Macrophages 
in vivo response of phagocytes to laser-induced fundus damage (mouse), 3649 
lack of IFN-γ synthesis in aqueous humor during corneal graft rejection and suppressed NO production by (rat), 4923 
LYVE-1-positive macrophages in human choroid, 5222 
recruitment of retinal microglia and uveal tract dendritic cells and macrophages in young mouse eye, 1599 
Macula 
confocal blue reflectance in type 2 idiopathic macular telangiectasia, 1172 
correlation between macular volume and focal macular ERG in RP, 3551 
macular pigment and AMD (new developments), 843 
macular thickness measurements on time domain and spectral domain OCT, 4893 
OCT thickness mapping of, 2046 
OCT thickness measurements based on ethnicity, 2668 
quantification of metamorphopsia in macular hole patients, 3741 
quantitative OCT analysis of idiopathic perifoveal telangiectasia, 2156 
recording focal macular photopic negative response from monkeys, 3544 
relation of macular pigment to foveal architecture, 2134 
visual acuity related to parafoveal retinal thickness in patients with RP and macular cysts, 4568 
Macular degeneration 
age-related (AMD) 
AMD-like lesions in rat retina after perinatal hemorrhage, 2790 
brightness, contrast, and color balance of digital vs. film retinal images in, 3269 
cataract surgery and risk of, 4795 
CCL2, CCR2, and TLR4 genes in, 364 
ceruloplasmin/hephaestin knockout mouse model of, 2728 
choroidal circulation and choroidal neovascularization in, 358 
coagulation gene predictors of PDT for neovascular AMD, 3100 
comparison of bevacizumab, ranibizumab, and pegaptanib in vitro, 4523 
complement factor H (CFH) polymorphism in 
 in Chinese patients, 3312 
 functional and structural implications of, 1763 
HTRA1 variants, smoking and, 2357 
 measurement in plasma using monoclonal antibodies, 1983 
 neovascular AMD in Koreans, 2071 
 10q26 gene cluster variants in AMD risk in Indian patients and, 1771 
documenting fixation at an extrafoveal locus in, 5274 
elastin gene polymorphisms in neovascular AMD and polypoidal choroidal vasculopathy, 1101 
elastin-mediated choroidal endothelial cell migration in, 5574 
fMRI study of eye movement control in, 1728 
focal macular ERG in wet-type AMD, 3121 
foveal cone–photoreceptor integrity in, 2077 
genotype–phenotype correlations for exudative AMD, 3090 
high-resolution spectral domain OCT in geographic atrophy associated with, 4137 
HLA-Cw*0701 genotype and NK cell receptor AA haplotype in, 5077 
imaging polarimetry in, 2661 
interleukin gene polymorphisms in, 693 
late outgrowth endothelial progenitor cells in, 2696 
lutein/zeaxanthin and omega-3 fatty acid supplementation in older adults, 3864 
macular pigment and AMD (new developments), 843 
mitochondrial proteomics of RPE in, 2848 
neovascular 
quantitative OCT findings in subtypes of, 5048 
in vivo 3-D optical frequency domain imaging at 1050 nm, 4545 
OCT repeatability in neovascular AMD, 1084 
peripheral vision and self-induced motion in, 3253 
phacoemulsification and neovascular AMD, 1079 
plasma-soluble Fas ligand and, 1345 
prevalence and risk factors in elderly Chinese population, 3126 
protection from membrane attack complex formation on murine RPE, 4126 
quantitative OCT after ranibizumab for neovascular AMD, 3115 
racial and other risk factors for, 2395 
repeatability of visual acuity scores in, 4347 
10q26 gene cluster variants and AMD risk in Indian patients, 1771 
Toll-like receptor polymorphisms and, 1652 
visual outcome after RPE–choroid translocation in, 758 
Stargardt disease, retinal dysfunction in patients and carrier relatives, 1191 
Macular dystrophy, microperimetry after autologous RPE-choroid graft in, 3143 
Macular edema, diabetic 
ETDRS severity scale for, 5041 
OCT vs. fundus photography of retinal thickening in, 1745 
repeatability of Stratus and Cirrus OCT in, 4290 
retinal vascular caliber changes after intravitreal triamcinolone for, 4707 
Macular Telangiectasia Project, National Eye Institute Visual Function Questionnaire in, 4340 
Maculopathy, age-related (ARM) 
macular vs. peripheral drusen in, 1200 
measuring rod and cone dynamics in, 55 
Magnetic resonance imaging (MRI) 
autoimmune optic neuritis in Marmoset monkeys, 3707 
functional (fMRI) 
effect of age and fixation instability on retinotopic mapping of primary visual cortex, 3734 
eye movement control in AMD, 1728 
in identification of human albinism, 238 
ionic dysregulatory phenotyping of pathologic retinal thinning with manganese-enhanced MRI, 3178 
manganese-enhanced MRI of DBA/2J mouse model of hereditary glaucoma, 5083 
in primate model of NAION, 2985 
Martin-Probst deafness mental retardation syndrome, 4096 
Matrix metalloproteinases (MMPs) 
downregulation of MMP-2 and -9 by proteasome inhibition, 1998 
elevated MMP expression in MRL mouse retina, 1686 
MMP-2 expression in melanoma-associated spongiform scleropathy, 2806 
podosome- or invadopodia-like structures for focal TM ECM turnover, 5353 
UV radiation and MMPs in ocular surface squamous neoplasia, 5295 
Mecamylamine, suppression of choroidal neovascularization, 1705 
Medications. See also Drug delivery 
blebbistatin prevention of inhibitory effects of thrombin on intercellular calcium wave propagation, 4816 
5-chlorouracil delivery using poly(ortho esters) in filtering surgery for glaucoma (rabbit), 2993 
comparison of bevacizumab, ranibizumab, and pegaptanib in vitro, 4523 
dexamethasone inhibition of inflammatory and angiogenic mediators, 2030 
differential suppression of corneal angiogenesis by NSAIDs (mouse), 3909 
drug modification of corneal angiogenesis (rat), 250 
effect of dorzolamide on retinal oxygen tension in BRVO (pig), 1136 
effect of eye pigmentation on transscleral drug delivery (rat), 333 
effect of methylprednisolone on RGCs and visual function after ocular ischemia (rat), 5003 
effects of bevacizumab on retinal cells in organotypic culture, 3164 
effects of timolol-dorzolamide fixed combination vs. latanoprost on circadian diastolic ocular perfusion pressure in glaucoma, 4226 
effects of triamcinolone acetonide on leukocyte dynamics in rat retinal microcirculation, 2127 
gene expression profiles of human TM cells induced by triamcinolone and dexamethasone, 1886 
improving therapeutic regimens for Bacillus endophthalmitis, 1480 
inhibition of neovascularization by blocking angiotensin II type 1 receptor (mouse), 4370 
intravitreal colchicine effects on RNFL (monkey), 255 
latanoprost-induced collagen gel contraction, 1429 
lovastatin-inhibited myofibroblast transdifferentiation in Tenon fibroblasts, 3955 
mecamylamine suppression of choroidal neovascularization, 1705 
mitomycin C–induced corneal endothelial DNA damage (goat), 4837 
ocular safety of intravitreal infliximab (rabbit), 1151 
paclitaxel-releasing polytetrafluoroethylene/polylactide-co-glycolide laminate after strabismus surgery (rabbit), 5340 
periocular triamcinolone enhances intraocular gene expression after adenoviral delivery (mouse), 399 
pharmacokinetics after periocular drug administration, 320 
pharmacokinetics of intraocular drug delivery of Oregon Green–labeled triamcinolone by subtenon injection (rabbit), 4506 
photoreceptor protection after PDT using dexamethasone (rat), 5008 
picropodophyllin treatment of choroidal neovascularization (mouse), 2620 
prostaglandin analogue reduction of oxidative stress in TM, 4872 
protective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in rabbit subretinal hemorrhage, 4071 
quantitative OCT after ranibizumab for neovascular AMD, 3115 
retinal microglia activation and optic nerve integrity with minocycline in murine glaucoma, 1437 
retinal vascular caliber changes after intravitreal triamcinolone for diabetic macular edema, 4707 
statin-mediated protection against diabetic retinopathy, 3131 
statin modulation of HSP expression and RGC survival after retinal ischemia/reperfusion (rat), 4971 
subretinal bevacizumab detection after intravitreous injection (rabbit), 1097 
triamcinolone acetonide inhibition of angiogenesis, 1184 
uveal melanoma growth inhibited by picropodophyllin, 2337 
Meibomian gland 
lipid composition of human meibum and tears, 3779 
sex steroids in regulation of gene expression in (mouse), 1797 
Melanoma, uveal 
B-RAF mutations in, 23 
chemokine receptor expression by, 636 
early oncogenic mutations in GNAQ in, 5230 
functional PD-L1 expression by, 2518 
gene expression profiling in, 4254 
high-frequency ultrasound of choroidal melanoma xenograft volume (rat), 16 
HSP90 inhibition in, 2348 
monosomy of chromosome 3 and inflammatory phenotype in, 505 
PI3K/Akt signaling in cell migration in, 497 
picropodophyllin-inhibited growth of, 2337 
RASEF as tumor-suppressor gene in, 1291 
resveratrol inhibition of tumor growth, 1299 
size overlap between benign melanocytic choroidal nevi and, 2823 
Melanoma-associated spongiform scleropathy, MMP-2 expression in, 2806 
Melanosomes 
effects of RPE melanosomes on photosensitized and iron-mediated oxidation, 2838 
OA1 and Gαi3 in melanosomal biogenesis and optic pathway formation (mouse), 3245 
Metabolic properties of rat oculorotatory EOMs, 4865 
Methods 
accuracy of bulbar redness grading scales, 1398 
analysis of atypical SLP patterns by polarization-sensitive OCT, 5366 
anterior chamber angle measurement with anterior segment OCT, 3469 
automated assessment of optic nerve head, 2512 
automatic recognition of corneal nerve structures in confocal microscopy images, 4801 
Bayesian machine learning classifiers for combining structural and functional measurements in glaucoma, 945 
binocular lens tilt and decentration measurements in phakic eyes, 2216 
biomechanical model of effect of viscosity and elasticity on hysteresis, 3919 
calculation of orbital soft tissue volumes, 1758 
comparison of HRT reference planes, 3970 
confocal blue reflectance in type 2 idiopathic macular telangiectasia, 1172 
contrast sensitivity perimetry test in glaucoma, 3049 
detection of corneal fibrosis by imaging second harmonic–generated signals (rabbit), 4377 
diagnostic accuracy of Matrix 24–2, N-30 frequency-doubling technology, and standard automated perimetry, 954 
documenting fixation at an extrafoveal locus in AMD, 5274 
dynamic contour tonometry vs. intracameral IOP measurements, 2472 
dynamic imaging of retinal microglia with time-lapse confocal microscopy (mouse), 4169 
endoscopic vitrectomy in keratoprosthesis exchange (rabbit), 4407 
estimation of ocular rigidity in primary open-angle glaucoma, 4046 
evaluating neural activity of RGCs by flash-evoked intrinsic signal imaging in macaque retina, 4655 
focal macular ERG in wet-type AMD, 3121 
fundus reflectometry measurement of retinal lutein and zeaxanthin, 5568 
high-resolution spectral domain OCT in geographic atrophy associated with AMD, 4137 
high-speed, ultrahigh-resolution OCT of outer retinal morphology, 1571 
HRT-3 Glaucoma Probability Score vs. stereophotography for prediction of glaucoma progression, 1898 
Humphrey Matrix detection of homonymous hemianopias, 924 
Humphrey Matrix perimetry in optic nerve and chiasmal disorders, 917 
imaging of mouse RGC death in vivo, 5546 
imaging polarimetry in AMD, 2661 
imaging technique for anterior and posterior segments (mouse), 5168 
impact of optic media opacities and image compression on quantitative analysis of OCT, 1609 
in vivo 3-D optical frequency domain imaging of neovascular AMD at 1050 nm, 4545 
ionic dysregulatory phenotyping of pathologic retinal thinning with manganese-enhanced MRI, 3178 
light-induced retinal changes observed with high-resolution autofluorescence imaging of RPE (macaque), 3715 
local diabetic retinopathy prediction by multifocal ERG over 3 years, 1622 
long-term follow-up of RP patients with multifocal ERG, 4664 
longitudinal imaging of RGC damage with confocal scanning laser ophthalmoscopy, 4898 
macular thickness measurements on time domain and spectral domain OCT, 4893 
measurement of complement factor H variants in plasma using monoclonal antibodies, 1983 
measurement of glucose utilization in cone-dominant ground squirrel retina, 4613 
measuring rod and cone dynamics in ARM, 55 
microperimetry after autologous RPE-choroid graft in macular dystrophy, 3143 
monitoring visual field defects in RP by quantitative OCT, 3617 
motion-detection threshold and measures of balance in older adults, 5257 
objective vision testing for inherited retinal disease (dog), 3568 
OCT macular thickness measurements based on ethnicity, 2668 
OCT repeatability in neovascular AMD, 1084 
OCT scan circle location and mean RNFL measurement variability, 2315 
OCT thickness mapping of human macula, 2046 
OCT vs. fundus photography of retinal thickening in diabetic macular edema, 1745 
ocular tissue release from a vibrating instrument, 1629 
off-flap Epi-LASIK for myopia, 2390 
PCO quantification by Pentacam tomograms, 2004 
plus disease in ROP: composite images, 4064 
quantification of metamorphopsia in macular hole patients, 3741 
quantification of retinal transneuronal degeneration in glaucoma, 1940 
quantitative OCT analysis of idiopathic perifoveal telangiectasia, 2156 
rapid acuity assessment using VEPs, 438 
real-time in vivo imaging of retinal cell apoptosis after laser exposure (rat), 2773 
recording focal macular photopic negative response from monkeys, 3544 
reliability of ocular response analyzer, 968 
reliability of retinal thickness measurements, 2627 
repeatability of Stratus and Cirrus OCT in diabetic macular edema, 4290 
repeatability of visual acuity scores in AMD, 4347 
retinal explant culture system as stem cell transplantation model, 3503 
RNFL analysis in RP patients using Fourier-domain OCT, 3525 
RNFL thickness measurements using 3D Fourier-domain OCT, 5386 
screening tests for open-angle glaucoma, 5373 
separation of two populations of mouse limbal stem cells, 3903 
standard reference height variability and its influence on HRT3 parameters, 4881 
ultra-high resolution imaging of cellular structure changes in optic neuropathies, 2103 
ultrahigh-speed OCT 3D and en face imaging of retina and optic nerve head, 5103 
uniformity of visual acuity measures in published studies, 4321 
wavelet analysis in infantile nystagmus syndrome, 3413 
N-Methyl-D-aspartate (NMDA) 
glutamate receptors in vertebrate retina (Proctor Lecture), 5184 
relaxation of porcine retinal arterioles via adenosine receptors, 4590 
RGC protection by α2 modulation of NMDA receptor function (rat), 4515 
Methylprednisolone, effect on RGCs and visual function after ocular ischemia (rat), 5003 
Microarray analysis 
estrogen and regulation in regulation of meibomian gland gene expression (mouse), 1797 
gene expression in rats that are susceptible or resistant to EAU, 1957 
gene expression profiles of human TM cells induced by triamcinolone and dexamethasone, 1886 
gene profiling of retinal detachment and reattachment (mouse), 511 
NFAT5 induction in hyperosmolar stressed limbal epithelial cells, 1827 
Microbial antigens and uveitis, 2526 
Microglia 
bone marrow–derived microglia in retina (mouse), 4162 
dynamic imaging of retinal microglia with time-lapse confocal microscopy (mouse), 4169 
in vivo response of phagocytes to laser-induced fundus damage (mouse), 3649 
microglia activation and optic nerve integrity with minocycline in murine glaucoma, 1437 
recruitment of retinal microglia and uveal tract dendritic cells and macrophages in young mouse eye, 1599 
Microwave radiation, effect of superimposed electromagnetic noise on DNA damage of lens epithelial cells, 2009 
Middle cerebral artery and retinal arteriolar responses to hypercarbic/hyperoxic stimuli, 5503 
Milk proteins, inhibition of Acanthamoeba-induced cytopathic effect, 1010 
Miller, Robert F., 2008 recipient of Proctor Medal, 5183 
Minocycline, retinal microglia activation and optic nerve integrity with minocycline in murine glaucoma, 1437 
Mitochondria 
mitochondrial complex I defect in primary open-angle glaucoma TM cells, 1447 
mitochondrial defects and dysfunction in calcium regulation in glaucomatous TM cells, 4912 
mitochondrial DNA oxidative damage in high glucose–induced human retinal endothelial cells, 4203 
mitochondrial OPA1 release in glaucomatous optic nerve (mouse), 4903 
mitochondrial proteomics of RPE in AMD, 2848 
mitochondrial trifunctional protein defects, carnitive palmitoyltransferse I and acyl-CoA dehydrogenase 9 in retina, 1660 
oxidative DNA damage in EAU (rat), 3299 
sporadic bilateral optic neuropathy in children and abnormalities of, 5250 
Mitomycin C–induced corneal endothelial DNA damage (goat), 4837 
MNREAD–nonlinear mixed-effects modeling, 828 
Monocyte chemoattractant protein-1 (MCP-1) deficiency and retinal neovascularization in murine ischemic retinopathy, 4195 
Mortality, visual impairment pathways to, 3318 
Motion-detection threshold and measures of balance in older adults, 5257 
Mucins 
antiadhesive character of mucin O-glycans at apical surface of corneal epithelial cells, 197 
membrane-associated mucin release from ocular surface epithelia, 1864 
Mucoadhesive microdiscs for drug delivery, 4808 
Mucolipin-1 channel conductance in mucolipidosis type IV, 3134 
Müller cells 
abnormal reactivity after retinal detachment in mice deficient in GFAP and vimentin, 3659 
α-aminoadipate induces progenitor cell properties of (mouse), 1142 
effect of electrical stimulation on BDNF induction in, 4641 
muscarinic receptor-activated calcium influx in (mouse), 3065 
PEDF regulation by, 5161 
response to blue light injury of rat retina, 3559 
Multiethnic Study of Atherosclerosis, cardiovascular risk factors for retinal vein occlusion, 4297 
Myocilin, Tyr43His mutant of human myocilin protein in glaucoma (mouse), 1932 
Myocyte enhancer factor-2C (MEF2C), induction in endothelial cells by VEGF, 3640 
Myopia 
adult-onset, 3324 
astigmatism in experimental myopia or hyperopia (chicken), 858 
canine model of inherited myopia, 4784 
corneal vertex vs. central pupil references with aberration-free ablation and LASIK, 5287 
effect of parental history of myopia on children’s eye size and growth, 873 
effect of progressive addition lenses on myopia progression in Japanese children, 2781 
effect of soft contact lenses on myopia progression in children, 4702 
Genes in Myopia Twin Study, shared genes in refraction and axial length, 4336 
influence of level of physical activity on, 1322 
near work–induced myopia additivity and decay characteristics, 836 
novel high myopia locus on 5p15, 3768 
ocular dominance and myopia development, 4779 
off-flap Epi-LASIK for, 2390 
peripheral refraction in infant monkeys, 3747 
personality and, 882 
PRK with solid state laser 213 nm and excimer laser 193 mn, 1415 
retinal ON pathway defect in (mouse), 706 
role of educational attainment in refraction, 534 
role of near work in myopia among Australian children, 2903 
TGIF as candidate gene for, 49 
time course of changes in ocular higher-order aberrations and contrast sensitivity after overnight orthokeratology, 4314 
and urban environment in Australian children, 3858 
visual function and myopia in rural Chinese children, 2888 
N
NADPH oxidase 
role in retinal vascular inflammation, 3139 
role in statin-mediated protection against diabetic retinopathy, 3131 
Naloxone neuroprotection against light-induced photoreceptor degeneration (rat), 2589 
National Eye Institute 
Ophthalmic Clinical Trial Design and Endpoints Symposium, 479 
Visual Function Questionnaire in Macular Telangiectasia Project, 4340 
Natural killer (NK) cells 
HLA-Cw*0701 genotype and NK cell receptor AA haplotype in AMD, 5077 
protective effects of CD1d-reactive invariant NK cells in corneal inflammation (mouse), 105 
Neovascularization 
in AMD 
choroidal circulation and, 358 
coagulation gene predictors of PDT for, 3100 
and complement factor H polymorphism in Koreans, 2071 
complement factor H polymorphism in Koreans and, 2071 
elastin gene polymorphisms in polypoidal choroidal vasculopathy and, 1101 
OCT repeatability in, 1084 
phacoemulsification and, 1079 
quantitative OCT after ranibizumab for, 3115 
quantitative OCT findings in subtypes of, 5048 
in vivo 3-D optical frequency domain imaging at 1050 nm, 4545 
choroidal 
astaxanthin inhibition of (mouse), 1679 
and choroidal circulation in AMD, 358 
dendritic cells and, 3666 
effects of anti–VEGF-A monoclonal antibody on (mouse), 1178 
N-(4-hydroxyphenyl) retinamide and (mouse), 1210 
in LOXL1-deficient mice, 2599 
mecamylamine suppression of, 1705 
picropodophyllin treatment of (mouse), 2620 
suppression by thioredoxin-1 interaction with complement factor H (mouse), 5118 
suppression by vaccine derived from VEGFR2 (mouse), 2143 
corneal 
PDT using polymeric micells encapsulating dendrimer porphyrins for, 894 
suppression by dendritic cell immunization against VEGFR2 (mouse), 2172 
HIF-2α haploinsufficiency and oxygen-induced retinopathy-associated neovascularization (mouse), 2714 
inhibition by blocking angiotensin II type 1 receptor (mouse), 4370 
MCP-1 deficiency and retinal neovascularization in murine ischemic retinopathy, 4195 
oxygen-induced neovascularization independent of VEGF in ROP (rat), 1591 
remodeling retinal neovascularization by ALK1 gene transfection, 4553 
and retinal expression of VLDLR in knockout mouse model of retinal angiomatous proliferation, 407 
targeted by nonpeptide somatostatin receptor agonists, 5094 
VEGF165 inhibition enhances PDT efficacy in ocular neovascularization (mouse), 662 
Nerves and innervation. See also Retinal nerve fiber layer 
age-related changes in rat corneal epithelial nerve density, 910 
autoimmune optic neuritis in Marmoset monkeys, 3707 
automated assessment of optic nerve head, 2512 
automatic recognition of corneal nerve structures in confocal microscopy images, 4801 
BDNF protection of ganglion cell morphology after optic nerve injury (cat), 2456 
cellular structure changes in optic neuropathies, 2103 
corneal hysteresis and optic nerve surface compliance in glaucoma, 3262 
effect of TGF-β2 in human optic nerve astrocytes, 1464 
effects of LINGO-1 antagonists on RGC survival after ocular hypertension and optic nerve transection (rat), 975 
endothelin-1 effect on fast axonal transport in rat optic nerve, 961 
engrafted chicken neural tube–derived stem cells support axonal regeneration in rat optic nerve, 3513 
glucose-6-phosphate dehydrogenase deficiency in NAION, 1328 
Humphrey Matrix perimetry in optic nerve and chiasmal disorders, 917 
in vivo confocal microscopy of sub-basal nerve plexus migration, 3409 
innervation of tissue-engineered recombinant human collagen-based corneal substitutes, 3895 
mitochondrial abnormalities and sporadic bilateral optic neuropathy in children, 5250 
mitochondrial OPA1 release in glaucomatous optic nerve (mouse), 4903 
optic nerve projections in human carriers of oculocutaneous albinism type 1a, 2756 
overlapping of retinal nerve fibers in horizontal plane, 1753 
oxidative stress and TGF-β2–induced HSP27 expression in optic nerve head astrocytes, 5403 
(+)-pentazocine protection against retinal neurodegeneration (mouse), 4154 
primate model of NAION, 2985 
protective effects of thioredoxins 1 and 2 in RGCs after optic nerve transection (rat), 3535 
rat AION induces RGC apoptosis, 3671 
retinal microglia activation and optic nerve integrity with minocycline in murine glaucoma, 1437 
RNFL birefringence and thickness and ERG after optic nerve transection (monkey), 4444 
thyroxine effects on embryonic chick corneal innervation, 139 
time-dependent effects of elevated IOP on optic nerve head axonal transport (pig), 986 
ultrahigh-speed OCT 3D and en face imaging of retina and optic nerve head, 5103 
VEGF mediation of corneal nerve repair, 3870 
Neuromyelitis optica, RNFL thickness in, 4412 
Neuronal ceroid lipofuscinosis, canine model of late infantile form of, 2686 
Neuronal NO in lactate-induced vasodilation (minipig), 5060 
Neurotransmitters, cell communication mechanisms in vertebrate retina (Proctor Lecture), 5184 
Neurotrophic factors 
BDNF and survival of retinal dopaminergic neurons (guinea pig), 1282 
regulation of Znt and ZIP zinc transporter expression in RPE, 1221 (erratum, 3811) 
Neutrophils 
neutrophil chemotaxis and IL-10 expression in tolerance of endotoxin-induced uveitis (rat), 5450 
protection of retina in HSV-1–injected eye by (mouse), 4018 
Nevi, size overlap between benign melanocytic choroidal nevi and melanoma, 2823 
New Developments 
authenticating cell lines in ophthalmic research laboratories, 4697 
macular pigment and AMD, 843 
NFAT5 induction in hyperosmolar stressed limbal epithelial cells, 1827 
Nitric oxide (NO) 
lack of IFN-γ synthesis in aqueous humor during corneal graft rejection and suppressed NO production by macrophages (rat), 4923 
neuronal NO in lactate-induced vasodilation (minipig), 5060 
in regulation of retinal blood flow in response to hyperoxia (cat), 4595 
role in somatostatin protection against retinal ischemia (rat), 342 
Nitrotyrosine expression and oxidative consequences in TM of glaucoma patients, 2506 
NOD2, in murine muramyl dipeptide–induced uveitis, 1518 
Nonarteritic anterior ischemic optic neuropathy (NAION) 
glucose-6-phosphate dehydrogenase deficiency in, 1328 
primate model, 2985 
Nonlinear mixed-effects modeling of MNREAD data, 828 
Nonpreserved care solutions and contact lens wear, 7 
Nonsteroidal anti-inflammatory drugs (NSAIDs), differential suppression of corneal angiogenesis by (mouse), 3909 
Nrf2-dependent antioxidant functions in RPE 
PI3 kinase/Akt pathway in regulation of, 1671 
Zip2 modulation of, 1665 
Nuclear factor-κB (NF-κB) 
delayed disruption of barrier function in cultured corneal epithelial cells induced by TNF-α dependent on, 565 
TRPV1 modulation of IL-6 and NFκB with pressure (mouse), 3004 
Nystagmus 
duration of binocular decorrelation and latent nystagmus in strabismic monkeys, 1872 
effect of aging on torsional optokinetic nystagmus, 589 
infantile nystagmus syndrome 
oscillopsia in, 3424 
stress effects in, 2977 
wavelet analysis in, 3413 
superior oblique palsy and torsional optokinetic nystagmus (monkey), 1421 
symmetry of look and stare optokinetic nystagmus, 581 
O
OA1 and Gαi3 in melanosomal biogenesis and optic pathway formation (mouse), 3245 
Obstructive sleep apnea, CPAP-related IOP increase in, 934 
Occludin, regulation of permeability in RPE cells by, 2568 
OCTN1 and OCTN2 expression in ocular epithelium, 4844 
Ocular biometry 
diurnal variation of axial length, IOP, and anterior eye biometrics, 2911 
effect of soft contact lenses on, 3371 
in preterm infants, 453 
Ocular dominance and myopia development, 4779 
Ocular hypertension. See also Glaucoma; Intraocular pressure 
effects of LINGO-1 antagonists on RGC survival after ocular hypertension and optic nerve transection (rat), 975 
in vivo confocal microscopy of conjunctival modifications in, 3042 
intracranial pressure in, 5412 
Ocular response analyzer, reliability of, 968 
Ocular surface 
defensin beta-109 expression in inflammation and infection, 28 
IL13/IL-4R gene polymorphisms in Stevens-Johnson syndrome with complications involving, 1809 
local production of secretory IgA in eye-associated lymphoid tissue of, 2322 
membrane-associated mucin release from epithelia of, 1864 
serum- and feeder-cell–free culture of corneal epithelium for reconstruction of, 2438 
suppression of ocular surface inflammation by expanded regulatory T cells (mouse), 5434 
UV radiation and MMPs in squamous neoplasia of, 5295 
Ocular torsion and cyclovertical strabismus (Weisenfeld Lecture), 847 
Oculocutaneous albinism type 1a, optic nerve projections in human carriers of, 2756 
Omega-3 fatty acids 
and ganglion cell function, 3586 
lutein/zeaxanthin and omega-3 supplementation in older adults, 3864 
in ROP (Friedenwald Lecture), 5177 
OPA1, mitochondrial release in glaucomatous optic nerve (mouse), 4903 
Ophthalmic Clinical Trial Design and Endpoints Symposium, 479 
Ophthalmic preservative, rabbit dry eye induced by benzalkonium chloride, 1850 
Opsin, thyroid hormone required for cone opsin expression during retinal development (mouse), 2039 
Optic disc 
correlation of photopic negative response with RNFL thickness and optic disc topography in glaucoma, 2201 
heritability of optic disc and cup in Chinese, 1350 
heritability of optic disc parameters, 77 
longitudinal variability of optic disc and RNFL measurements, 4886 
OCT study of retinal and optic disc findings in adolescents, 4328 
Optic nerve 
autoimmune optic neuritis in Marmoset monkeys, 3707 
automated assessment of optic nerve head, 2512 
BDNF protection of ganglion cell morphology after optic nerve injury (cat), 2456 
cellular structure changes in optic neuropathies, 2103 
corneal hysteresis and optic nerve surface compliance in glaucoma, 3262 
effect of TGF-β2 in human optic nerve astrocytes, 1464 
effects of LINGO-1 antagonists on RGC survival after ocular hypertension and optic nerve transection (rat), 975 
endothelin-1 effect on fast axonal transport in rat optic nerve, 961 
engrafted chicken neural tube–derived stem cells support axonal regeneration in rat optic nerve, 3513 
glucose-6-phosphate dehydrogenase deficiency in NAION, 1328 
Humphrey Matrix perimetry in optic nerve and chiasmal disorders, 917 
mitochondrial abnormalities and sporadic bilateral optic neuropathy in children, 5250 
mitochondrial OPA1 release in glaucomatous optic nerve (mouse), 4903 
optic nerve projections in human carriers of oculocutaneous albinism type 1a, 2756 
oxidative stress and TGF-β2–induced HSP27 expression in optic nerve head astrocytes, 5403 
primate model of NAION, 2985 
protective effects of thioredoxins 1 and 2 in RGCs after transection of (rat), 3535 
rat AION induces RGC apoptosis, 3671 
retinal microglia activation and optic nerve integrity with minocycline in murine glaucoma, 1437 
RNFL birefringence and thickness and ERG after optic nerve transection (monkey), 4444 
time-dependent effects of elevated IOP on optic nerve head axonal transport (pig), 986 
ultrahigh-speed OCT 3D and en face imaging of retina and optic nerve head, 5103 
Optical coherence tomography (OCT) 
analysis of atypical SLP patterns by polarization-sensitive OCT, 5366 
anterior chamber angle measurement with anterior segment OCT, 3469 
cellular structure changes in optic neuropathies, 2103 
differential optical densities of intraretinal spaces, 3529 
of foveal fine structure in ROP, 2061 
vs. fundus photography of retinal thickening in diabetic macular edema, 1745 
heritability of iridotrabecular angle width in Chinese children, 1356 
high-resolution spectral domain OCT in geographic atrophy associated with AMD, 4137 
high-speed, ultrahigh-resolution OCT of outer retinal morphology, 1571 
imaging polarimetry in AMD, 2661 
impact of diabetic retinopathy on quantitative RNFL measurement and glaucoma screening, 687 
impact of optic media opacities and image compression on quantitative analysis of, 1609 
longitudinal variability of optic disc and RNFL measurements, 4886 
macular thickness measurements based on ethnicity, 2668 
macular thickness measurements on time domain and spectral domain OCT, 4893 
monitoring visual field defects in RP by quantitative OCT, 3617 
of morphologic changes in geographic atrophy, 3095 
OCT scan circle location and mean RNFL measurement variability, 2315 
overlapping of retinal nerve fibers in horizontal plane, 1753 
phase-contrast OCT of transverse flows in mouse retina and choroid, 5055 
photoreceptor layer topography in children with Leber congenital amaurosis due to RPE65 mutations, 4573 
quantitative analysis of idiopathic perifoveal telangiectasia, 2156 
quantitative OCT after ranibizumab for neovascular AMD, 3115 
quantitative OCT findings in subtypes of neovascular AMD, 5048 
reliability of retinal thickness measurements, 2627 
repeatability in neovascular AMD, 1084 
repeatability of Stratus and Cirrus OCT in diabetic macular edema, 4290 
retinal and optic disc findings in adolescents, 4328 
retinal function in Best macular dystrophy, 5553 
retinal structure in human RP caused by Rhodopsin mutations, 1580 
RNFL analysis in RP patients using Fourier-domain OCT, 3525 
of RNFL thickness in prediction of visual recovery after parachiasmal tumor surgery, 1879 
RNFL thickness measurements using 3D Fourier-domain OCT, 5386 
thickness mapping of human macula, 2046 
ultrahigh-speed OCT 3D and en face imaging of retina and optic nerve head, 5103 
visual acuity related to parafoveal retinal thickness in patients with RP and macular cysts, 4568 
Optical power of isolated human crystalline lens, 2541 
Optical quality of eyes with normal and excellent vision, 4688 
Orbital drainage of radiolabeled colloids (rabbit), 2563 
Orbital soft tissue volumes, calculation of, 1758 
Orthokeratology, overnight, time course of changes in ocular higher-order aberrations and contrast sensitivity after, 4314 
Oscillopsia, in infantile nystagmus syndrome, 3424 
Osteopontin 
corneal wound healing in osteopontin-deficient mouse, 1367 
expression in rat retina after injury, 762 
Outflow 
anandamide-induced increase in aqueous outflow facility, 4528 
effects of cyclic IOP on conventional outflow facility, 275 
ex vivo model of CSF outflow across human arachnoid granulations, 4721 
glycosaminoglycan biosynthesis and outflow facility in perfusion culture, 2495 
hydrodynamic and morphologic changes in aqueous humor outflow pathway after IOP elevation (cow), 5346 
pharmacologic inhibition of GGTase-I and aqueous humor outflow, 2464 
Oxidative stress 
alterations in lysosomal function in porcine TM cells induced by, 3961 
antioxidant effect of quercetin in human RPE, 1712 
effect of thioltransferase deletion on cellular sensitivity to oxidative stress in lens epithelial cells (mouse), 4497 
hypersensitive response to, in keratoconus corneal fibroblasts, 4361 
mitochondrial complex I defect in primary open-angle glaucoma TM cells, 1447 
mitochondrial DNA oxidative damage in high glucose–induced human retinal endothelial cells, 4203 
nitrotyrosine expression and oxidative consequences in TM of glaucoma patients, 2506 
prostaglandin analogue reduction of, in TM, 4872 
proteasome as target of oxidative damage in RPE cells, 3622 
protective effects of thioredoxins 1 and 2 in RGCs after optic nerve transection and (rat), 3535 
and retinol dehydrogenases RDH11 and RDH12 in mouse retina, 1071 
selective degeneration of central photoreceptors after hyperbaric oxygen (mouse), 3207 
sulforaphane protection of RPE cells against, 2606 
and TGF-β2–induced HSP27 expression in optic nerve head astrocytes, 5403 
zeaxanthin effects on retinal metabolic abnormalities in diabetic rats, 1645 
Oxr1, in hyperoxia-challenged mouse retina, 4561 
Oxygen 
age-dependent control of lens growth by hypoxia, 1023 
effect of dorzolamide on retinal oxygen tension in BRVO (pig), 1136 
effect of mild hypoxia on chromatic sensitivity, 820 
effects of photocoagulation on intraretinal PO2 (cat), 380 
HIF-2α haploinsufficiency and oxygen-induced retinopathy-associated neovascularization (mouse), 2714 
local neuroretinal function during acute hypoxia in older people, 807 
NO in regulation of retinal blood flow in response to hyperoxia (cat), 4595 
Oxr1 in hyperoxia-challenged mouse retina, 4561 
oxygen-induced neovascularization independent of VEGF in ROP (rat), 1591 
retinal arteriolar and middle cerebral artery responses to hypercarbic/hyperoxic stimuli, 5503 
retinal arteriolar hemodynamic response to hyperoxia and glucose in diabetic retinopathy, 699 
retinal effects of postnatal hyperoxia in neonatal rat, 458 
P
P2X7, role in cornea (mouse), 4384 
P2Y receptor subtypes regulate calcium signaling in RPE, 350 
p27, ubiquitination pathway for p27 degradation in corneal endothelial cells, 189 
p32 protein, FOXC1-interacting, 5243 
p53, antioxidant function in RGCs, 4237 
Paclitaxel-releasing polytetrafluoroethylene/polylactide-co-glycolide laminate after strabismus surgery (rabbit), 5340 
Pakistan National Blindness and Visual Impairment Survey: prevalence and causes of functional low vision, 887 
Panretinal photocoagulation, effects of triamcinolone acetonide on leukocyte dynamics in rat retinal microcirculation after, 2127 
Pattern-related visual stress, visual search and, 4210 
Pediatric population 
anisometropia, amblyopia, and stereoacuity in school children with high prevalence of astigmatism, 4427 
association of CTLA-4 and IL-13 gene polymorphisms with Graves’ disease and ophthalmopathy in Chinese children, 2409 
ciliary body thickness and refractive error in children, 4353 
computerized analysis of retinal vessel width and tortuosity in premature infants, 3577 
cone ERG in ROP, 814 
corneal biomechanical characteristics and refractive error in Singaporean children, 3852 
corneal curvature and axial length in children with congenital/infantile cataract, 4774 
effect of amblyopia on fine motor skills, 594 
effect of parental history of myopia on children’s eye size and growth, 873 
effect of progressive addition lenses on myopia progression in Japanese children, 2781 
effect of soft contact lenses on myopia progression in, 4702 
glaucoma risk after pediatric cataract surgery, 1791 (erratum, 2805) 
heritability of iridotrabecular angle width in Chinese children, 1356 
interactions between TM cells and lens epithelial cells in infantile aphakic glaucoma, 3981 
IOP in preterm infants, 87 
mitochondrial abnormalities and sporadic bilateral optic neuropathy in, 5250 
myopia and urban environment in Australian children, 3858 
objective accommodative amplitudes by age, 2919 
OCT of foveal fine structure in ROP, 2061 
OCT study of retinal and optic disc findings in adolescents, 4328 
ocular biometry in preterm infants, 453 
ocular dominance and myopia development, 4779 
ocular growth and refractive error development in ROP, 5199 
photoreceptor layer topography in children with Leber congenital amaurosis due to RPE65 mutations, 4573 
plus disease in ROP: composite images, 4064 
prevalence and causes of functional low vision in school-age children, 877 
relationship of retinal vessel diameter parameters in 6-year-olds, 2403 
resolution visual fields in children surgically treated for congenital cataract, 3730 
role of near work in myopia among Australian children, 2903 
spectacle acceptance among rural Chinese children, 2895 
timing of surgery for infantile esotropia, 3432 
understanding retinopathy through ROP (Friedenwald Lecture), 5177 
visual function and myopia in rural Chinese children, 2888 
visual impairment in school children in Brazil, 4308 
visual sensory and motor deficits in children with cerebral palsy, 572 
Pegaptanib 
compared with bevacizumab and ranibizumab in vitro, 4523 
VEGF165 inhibition enhances PDT efficacy in ocular neovascularization (mouse), 662 
Pentacam tomograms, PCO quantification by, 2004 
(+)-Pentazocine protection against retinal neurodegeneration (mouse), 4154 
Perceptual thresholds in epiretinal prostheses, 2303 
Pericytes 
dexamethasone inhibition of inflammatory and angiogenic mediators from retinal microvascular pericytes, 2030 
inhibition of pericyte loss and endothelial cell growth by aldose reductase inhibitor, 3216 
Tie-2 in pericyte survival and recruitment in diabetic retinopathy, 2163 
Perimetry 
contrast sensitivity perimetry test in glaucoma, 3049 
diagnostic accuracy of Matrix 24–2, N-30 frequency-doubling technology, and standard automated perimetry, 954 
HRT-3 Glaucoma Probability Score vs. stereophotography for prediction of glaucoma progression, 1898 
Humphrey Matrix detection of homonymous hemianopias, 924 
Humphrey Matrix perimetry in optic nerve and chiasmal disorders, 917 
mapping standard automated perimetry to RNFL in glaucoma, 3018 
microperimetry after autologous RPE-choroid graft in macular dystrophy, 3143 
neural rim characteristics of healthy South Indians, 3457 
Peripheral vision, and self-induced motion in AMD, 3253 
Peroxiredoxins, in Fuchs endothelial corneal dystrophy, 2946 
Peroxynitrite in glaucoma, 2506 
Personality and myopia, 882 
Phacoemulsification, neovascular AMD and, 1079 
Pharmacokinetics after periocular drug administration, 320 
Pharmacologic activity of Physalis peruviana fruit juice (rabbit), 3074 
Phenotype 
genotype–phenotype correlations for exudative AMD, 3090 
Gif1 mutation, lens development, and small-eye mouse phenotype, 1525 
induction of photoreceptor phenotype by exogenous Crx expression in mouse retinal stem cells, 429 
ionic dysregulatory phenotyping of pathologic retinal thinning with manganese-enhanced MRI, 3178 
monosomy of chromosome 3 and inflammatory phenotype in uveal melanoma, 505 
variation in enhanced S-cone syndrome, 2082 
Phosphatidylinositol 3-kinase (PI3K)/Akt signaling 
IGF-1R/PI3K/AKT signaling in rod outer segments, 4765 
in normal rat retinas and RGCs, 3687 
in regulation of Nrf2-dependent antioxidant functions in RPE, 1671 
in uveal melanoma cell migration, 497 
Photocoagulation 
effects on intraretinal PO2 (cat), 380 
healing of retinal lesions from, 5540 
Photodynamic therapy (PDT) 
coagulation gene predictors of PDT for neovascular AMD, 3100 
for corneal neovascularization using polymeric micells encapsulating dendrimer porphyrins, 894 
effects of verteporfin PDT on retinoblastoma cell lines, 3158 
evaluation of new photosensitizer Stakel for (rabbit and rat), 1633 
photoreceptor protection after PDT using dexamethasone (rat), 5008 
VEGF165 inhibition enhances PDT efficacy in ocular neovascularization (mouse), 662 
Photoreceptors 
age-related cone abnormalities in zebrafish with genetic lesions in sonic hedgehog, 4631 
α-aminoadipate induces progenitor cell properties of Müller glia (mouse), 1142 
cell communication mechanisms in vertebrate retina (Proctor Lecture), 5184 
cones in rhodopsin mutant P23H-3 retina (rat), 1116 
αA-crystallin–associated photoreceptor protection in experimental uveitis (mouse), 1161 
failure of Rpe65−/−/Nrl−/− mice to generate cone outer segments, 1126 (erratum, 1762) 
FGF-19 neuroprotective effects on adult photoreceptors, 1696 
foveal cone–photoreceptor integrity in AMD, 2077 
functional rescue of degenerating photoreceptors in Pde6bH620Q mice, 5067 
G-CSF protection against light-induced damage (mouse), 5629 
GUCY2D mutations in autosomal dominant progressive cone degeneration, 5015 
hypothesis for outer segment renewal in (perspectives), 3259 
identification of photoreceptor precursors in pars plana (mouse), 422 
IGF-1R/P3K/AKT signaling in rod outer segments, 4765 
IL-6 as photoreceptor neuroprotectant in experimental retinal detachment (mouse, rat), 3193 
induction of photoreceptor phenotype by exogenous Crx expression in mouse retinal stem cells, 429 
influence of quantitative trait locus on mouse chromosome 19 to cone ERG, 4058 
in vivo labeling of mammalian cones, 2643 
interaction of CaBP4 and Unc119 in (mouse), 2366 
intrinsic signals from human cone photoreceptors, 713 
KCNV2 mutations in cone dystrophy with supernormal rod responses, 751 
long-term vision rescue by human neural progenitors in rat model of photoreceptor degeneration, 3201 
measuring rod and cone dynamics in ARM, 55 
naloxone neuroprotection against light-induced photoreceptor degeneration (rat), 2589 
phenotypic variation in enhanced S-cone syndrome, 2082 
photoreceptor layer topography in children with Leber congenital amaurosis due to RPE65 mutations, 4573 
photoreceptor preservation in murine retinal detachment, 781 
protection after PDT using dexamethasone (rat), 5008 
protective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in rabbit subretinal hemorrhage, 4071 
protective effect of saffron supplement on retinal stress (rat), 1254 
of Prpf3 knockout mice and zebrafish, 3830 
recovery of rod photoreceptors in ABCR-deficient mice, 2743 
reprogramming progeny cells of embryonic chick RPE to produce, 4145 
retinal changes in early-onset cone–rod dystrophy (dog), 1106 
RhoA and synaptic plasticity of salamander photoreceptors, 4177 
Rpe65−/− and Lrat−/− murine models of Leber congenital amaurosis, 2384 
selective degeneration of central photoreceptors after hyperbaric oxygen (mouse), 3207 
tauroursodeoxycholic acid preservation of photoreceptors in rd10 mice through postnatal day 30, 2148 
thyroid hormone required for cone opsin expression during retinal development (mouse), 2039 
variation in cone packing density and refractive error, 4679 
Photorefractive keratectomy (PRK), with solid state laser 213 nm and excimer laser 193 mn, 1415 
Physalis peruviana fruit juice, pharmacologic activity of (rabbit), 3074 
Physical activity level and myopia, 1322 
Picropodophyllin 
for choroidal neovascularization (mouse), 2620 
uveal melanoma growth inhibited by, 2337 
Pigment epithelium–derived factor (PEDF), regulation by Müller cells, 5161 
Pigmentation 
autosomal recessive ocular albinism in Caucasian patients, 868 
effect on transscleral drug delivery (rat), 333 
macular pigment and AMD (new developments), 843 
relation of macular pigment to foveal architecture, 2134 
Plasma-soluble Fas ligand and AMD, 1345 
Plasmapheresis, effect on hyperviscosity-related retinopathy and retinal hemodynamics in Waldenström’s macroglobulinemia, 1157 
Plasmin, in vitreous processing of PDGF-C in proliferative vitreoretinopathy, 42 
Platelet-derived growth factor (PDGF), plasmin in vitreous processing of PDGF-C in proliferative vitreoretinopathy, 42 
Plus disease in ROP: composite images, 4064 
Pneumolysin antiserum, passive immunization against S. pneumoniae keratitis (rabbit), 290 
Pneumotomography, estimation of ocular rigidity in primary open-angle glaucoma, 4046 
Poggendorff effect with subjective contours, 474 
Poloxamers for deswelling of organ-cultured corneas, 550 
Poly(I:C) in immunoinflammatory response in cultured corneal fibroblasts, 3336 
Polymerase chain reaction (PCR), for bacterial identification in postcataract surgery endophthalmitis, 1971 
Polypoidal choroidal vasculopathy, 4729 
elastin gene polymorphisms in neovascular AMD and, 1101 
gene polymorphisms in Chinese patients with, 2613 
Polysomnography, CPAP-related IOP increase in obstructive sleep apnea, 934 
Posterior capsular opacification (PCO) 
downregulation of MMP-2 and -9 by proteasome inhibition and lens epithelial cell migration, 1998 
quantification by Pentacam tomograms, 2004 
Posterior parietal cortex effects on binocular coordination, 230 
Premature infants 
IOP in, 87 
ocular biometry in, 453 
ocular growth and refractive error development in ROP, 5199 
understanding retinopathy through ROP (Friedenwald Lecture), 5177 
Proctor Lecture 
cell communication mechanisms in vertebrate retina, 5184 
Robert F. Miller, 2008 recipient of Proctor Medal, 5183 
Progesterone, in regulation of meibomian gland gene expression (mouse), 1797 
Proinsulin neuroprotection in mouse model of RP, 4188 
Proliferative vitreoretinopathy, plasmin in vitreous processing of PDGF-C in, 42 
Prostaglandin analogues, reduction of oxidative stress in TM by, 4872 
Prostheses and implants. See also Biomaterials 
effect of retinal prosthesis implant location on pursuit eye movements, 3933 
factors affecting perceptual thresholds in epiretinal prostheses, 2303 
Proteasome, oxidative damage of, 3622 
Protective effects 
anti-apoptotic effects of TFF1 in conjunctival cells, 3790 
antioxidant effect of quercetin in human RPE, 1712 
against apoptosis by exogenous glutathione in Leber hereditary optic neuropathy, 671 
BDNF protection of ganglion cell morphology after optic nerve injury (cat), 2456 
of CD1d-reactive invariant NK cells in corneal inflammation (mouse), 105 
connexin43-mediated protection of ARPE-19 cells, 800 
αA-crystallin–associated photoreceptor protection in experimental uveitis (mouse), 1161 
erythropoietin protection of retinal cells in diabetes (rat), 732 
FGF-19 neuroprotective effects on adult photoreceptors, 1696 
G-CSF protection of photoreceptors against light-induced damage (mouse), 5629 
IL-6 as photoreceptor neuroprotectant in experimental retinal detachment (mouse, rat), 3193 
inhibition of Acanthamoeba-induced cytopathic effect by milk proteins, 1010 
of intravitreal triamcinolone acetonide against photoreceptor apoptosis in rabbit subretinal hemorrhage, 4071 
KGF protection of corneal epithelial cells from hypoxia-induced disruption of barrier function, 2432 
of naloxone against light-induced photoreceptor degeneration (rat), 2589 
neutrophil protection of retina in HSV-1–injected eye (mouse), 4018 
passive immunization against S. pneumoniae keratitis (rabbit), 290 
(+)-pentazocine protection against retinal neurodegeneration (mouse), 4154 
photoreceptor preservation in murine retinal detachment, 781 
photoreceptor protection after PDT using dexamethasone (rat), 5008 
of proinsulin in mouse model of RP, 4188 
protection from membrane attack complex formation on murine RPE in AMD, 4126 
ς-1 receptor neuroprotection in RGC-5 cells, 2577 
RGC protection by α2 modulation of NMDA receptor function (rat), 4515 
saffron supplement and retinal stress (rat), 1254 
of somatostatin in rat retina, 3081 
somatostatin protection against retinal ischemia (rat), 342 
statin-mediated protection against diabetic retinopathy, 3131 
statin modulation of HSP expression and RGC survival after retinal ischemia/reperfusion (rat), 4971 
sulforaphane protection of RPE cells against oxidative stress, 2606 
tauroursodeoxycholic acid preservation of photoreceptors in rd10 mice through postnatal day 30, 2148 
of thioredoxins 1 and 2 in RGCs after optic nerve transection (rat), 3535 
Protein tyrosine phosphatases (PTBs), association of PTB-1B with c-Met receptor and modulation of corneal wound healing (rabbit), 2927 
Proteomics 
of climatic keratopathy droplets, 2829 
14–3–3 proteins in regulation of bad trafficking in RGCs (rat), 2483 
mitochondrial proteomics of RPE in AMD, 2848 
Prox1, in regulation of chicken βB1-crystallin promoter, 1542 
Prpf3 knockout mice and zebrafish, 3830 
Pseudoexfoliation syndrome 
association of LOXL1 common sequence variants in, 1459 
and LOXL1 polymorphisms in Japanese, 3976 
Pseudomonas aeruginosa keratitis 
degradation of secretory IgA in tears in, 4939 
effects of lipid raft disruption in (mouse), 1000 
substance P promotes susceptibility to (mouse), 1502 
substance P–induced delay in apoptosis after (mouse), 4458 
Q
Quality of life 
impact of glaucoma, lens opacities, and cataract surgery on visual functioning and, 1333 
National Eye Institute Visual Function Questionnaire in Macular Telangiectasia Project, 4340 
and priorities of glaucoma patients, 1907 
Timor-Leste vision-specific quality-of-life questionnaire, 4284 
and visual function in elderly women with cataracts, 1 
Quercetin, antioxidant effect in human RPE, 1712 
R
Race/ethnicity 
estimating rate of progressive visual field damage in open-angle glaucoma, 66 
ethnic variability in retinal vessel caliber, 1362 
Los Angeles Latino Eye Study, uncorrected refractive error in Latinos, 5264 
Multiethnic Study of Atherosclerosis, cardiovascular risk factors for retinal vein occlusion, 4297 
OCT macular thickness measurements based on ethnicity, 2668 
racial and other risk factors for AMD, 2395 
Radiolabeled colloids, orbital drainage of (rabbit), 2563 
Ranibizumab 
compared with bevacizumab and pegaptanib in vitro, 4523 
for neovascular AMD, quantitative OCT after, 3115 
RASEF, as tumor-suppressor gene in uveal melanoma, 1291 
Reading 
near work–induced myopia additivity and decay characteristics, 836 
nonlinear mixed-effects modeling of MNREAD data, 828 
ς-1 Receptor neuroprotection in RGC-5 cells, 2577 
Rectus muscles. See also Extraocular muscles 
activated satellite cells in medial rectus muscles in strabismus, 215 
inflection in inactive lateral rectus muscle, 4858 
Red eye, accuracy of bulbar redness grading scales, 1398 
Refraction, development of refractive status and ocular growth in C57BL/6 mice, 5208 
Refractive error 
adult-onset myopia, 3324 
anisometropia, amblyopia, and stereoacuity in school children with high prevalence of astigmatism, 4427 
astigmatism in experimental myopia or hyperopia (chicken), 858 
canine model of inherited myopia, 4784 
and ciliary body thickness in children, 4353 
and corneal biomechanical characteristics in Singaporean children, 3852 
effect of parental history of myopia on children’s eye size and growth, 873 
effect of progressive addition lenses on myopia progression in Japanese children, 2781 
effect of soft contact lenses on myopia progression in children, 4702 
epithelial thickness changes due to CRTH rigid gas-permeable contact lenses, 3345 
Genes in Myopia Twin Study, shared genes in refraction and axial length, 4336 
influence of level of physical activity on myopia, 1322 
Los Angeles Latino Eye Study, uncorrected refractive error in Latinos, 5264 
myopia and personality, 882 
myopia and urban environment in Australian children, 3858 
near work–induced myopia additivity and decay characteristics, 836 
novel high myopia locus on 5p15, 3768 
ocular dominance and myopia development, 4779 
ocular growth and refractive error development in ROP, 5199 
off-flap Epi-LASIK for myopia, 2390 
peripheral refraction in infant monkeys, 3747 
retinal ON pathway defect in myopia (mouse), 706 
role of educational attainment in refraction, 534 
role of near work in myopia among Australian children, 2903 
spectacle acceptance among rural Chinese children, 2895 
TGIF as candidate gene for myopia, 49 
time course of changes in ocular higher-order aberrations and contrast sensitivity after overnight orthokeratology, 4314 
variation in cone packing density and, 4679 
visual function and myopia in rural Chinese children, 2888 
Refractive index 
changes in distribution with age and accommodation, 2531 
intratissue refractive index shaping of cornea and lens (cat), 5332 
optical power of isolated human crystalline lens, 2541 
Refractive surgery 
chronic dry eye after LASIK, 168 
corneal vertex vs. central pupil references with aberration-free ablation and LASIK, 5287 
effects of cyclotorsional errors during, 4828 
in vivo confocal microscopic evaluation of corneal wound healing after Epi-Lasik, 2416 
off-flap Epi-LASIK for myopia, 2390 
PRK with solid state laser 213 nm and excimer laser 193 mn, 1415 
Research laboratories, authenticating cell lines in, New Developments, 4697 
Research opportunities 
drug delivery to posterior intraocular tissues, 4712 
Ophthalmic Clinical Trial Design and Endpoints Symposium, 479 
Resveratrol, inhibition of uveal melanoma tumor growth, 1299 
Retinal degeneration 
and amyloid-β in mouse model of Alzheimer disease, 5136 
CNTF modulation of electrical retinal stimulation thresholds (rat), 372 
delay in rd10 mouse by gene therapy, 4278 
genetic modifiers in rd3 mouse, 2863 
(+)-pentazocine protection against retinal neurodegeneration (mouse), 4154 
in RCS rat, phototopic ERG from amacrine cell signaling in, 442 
sialoadhesin expression in degenerating retinas after transplantation (mouse), 5602 
visual phenotype of Rpe65rd12 and rd/rd mice, 2737 
Retinal detachment 
abnormal reactivity of Müller cells after retinal detachment in mice deficient in GFAP and vimentin, 3659 
gene expression changes in (pig), 1262 
IL-6 as photoreceptor neuroprotectant in rodent model of, 3193 
photoreceptor preservation in (mouse), 781 
and reattachment, gene profiling of (mouse), 511 
rhegmatogenous, LOX in proliferative diabetic retinopathy and, 4746 
Retinal ganglion cells (RGCs) 
abnormalities in Ins2Akita diabetic mice, 2635 
age-related losses of axons and, 4437 
antioxidant function of p53 in, 4237 
BDNF protection of ganglion cell morphology after optic nerve injury (cat), 2456 
effect of IL-1β on energy metabolism of R28 and RGC-5 retinal neurons, 5581 
effect of methylprednisolone after ocular ischemia (rat), 5003 
effects of LINGO-1 antagonists on RGC survival after ocular hypertension and optic nerve transection (rat), 975 
evaluating neural activity of RGCs in macaque retina, 4655 
14–3–3 proteins in regulation of bad trafficking in (rat), 2483 
imaging of mouse RGC death in vivo, 5546 
in vivo imaging of (macaque), 467 
longitudinal imaging of RGC damage with confocal scanning laser ophthalmoscopy, 4898 
omega-3 fatty acids and function of, 3586 
PI 3-kinase signaling in normal rat retinas and, 3687 
protective effects of thioredoxins 1 and 2 in RGCs after optic nerve transection (rat), 3535 
quantification of ischemic damage in rat retina, 1056 
quantification of retinal transneuronal degeneration in glaucoma, 1940 
rat AION induces RGC apoptosis, 3671 
ς-1 receptor neuroprotection in RGC-5 cells, 2577 
retinal microglia activation and optic nerve integrity with minocycline in murine glaucoma, 1437 
RGC protection by α2 modulation of NMDA receptor function (rat), 4515 
sigma-1 receptor regulation of voltage-gated calcium channels in, 4993 
statin modulation of HSP expression and RGC survival after retinal ischemia/reperfusion (rat), 4971 
system N glutamine transporters in, 5151 
Retinal nerve fiber layer (RNFL) 
analysis in RP patients using Fourier-domain OCT, 3525 
correlation of photopic negative response with RNFL thickness and optic disc topography in glaucoma, 2201 
impact of diabetic retinopathy on quantitative RNFL measurement and glaucoma screening, 687 
intravitreal colchicine effects on (monkey), 255 
longitudinal variability of optic disc and RNFL measurements, 4886 
mapping standard automated perimetry to RNFL in glaucoma, 3018 
morphometric analysis of human peripapillary RNFL thickness, 941 
OCT of RNFL thickness in prediction of visual recovery after parachiasmal tumor surgery, 1879 
OCT scan circle location and mean RNFL measurement variability, 2315 
overlapping of retinal nerve fibers in horizontal plane, 1753 
RNFL birefringence and thickness and ERG after optic nerve transection (monkey), 4444 
RNFL thickness measurements using 3D Fourier-domain OCT, 5386 
thickness in neuromyelitis optica, 4412 
Retinal pigment epithelium (RPE) 
amyloid β accumulation and upregulation of angiogenic factors in ARPE19 cells, 2376 
anti-apoptotic role of αB-crystallin in RPE cells, 4753 
anti-inflammatory effects of AICAR in RPE cells, 1274 
antioxidant effect of quercetin in human RPE, 1712 
autologous partial thickness RPE-choroid transplantation (rabbit), 3185 
characterization of spontaneous mouse RPE cell line B6-RPE07, 3699 
connexin43-mediated protection of ARPE-19 cells, 800 
control of chemokine gradients by, 4620 
effects of benzo(e)pyrene on, 5111 
effects of RPE melanosomes on photosensitized and iron-mediated oxidation, 2838 
FKBP8 in RPE apoptosis, 1721 
inducible expression of Cre recombinase in (mouse), 1248 
iron regulates L-cystine uptake and glutathione levels in, 310 
light-induced retinal changes observed with high-resolution autofluorescence imaging of (macaque), 3715 
lipofuscin pigments in RPE of abca4−/− mice after vitamin A supplementation, 3821 
microperimetry after autologous RPE-choroid graft in macular dystrophy, 3143 
mitochondrial proteomics of RPE in AMD, 2848 
occludin regulation of permeability in, 2568 
P2Y receptor subtypes regulate calcium signaling in, 350 
PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in, 1671 
proteasome as target of oxidative damage in, 3622 
protection from membrane attack complex formation on murine RPE in AMD, 4126 
rabbit model of RPE transplantation, 4115 
regulated expression of caspase-12 gene in, 5593 
reprogramming progeny cells of embryonic chick RPE to produce photoreceptors, 4145 
rescue in RCS rats after late-stage RPE transplantation, 416 
restoration of lysosomal pH in RPE cells, 772 
serum-free culture of human prenatal RPE cells, 788 
sulforaphane protection of RPE cells against oxidative stress, 2606 
topical doxycycline induction of BDNF in (rat), 3631 
UBE2E3 required for proliferation of, 5611 
visual outcome after RPE–choroid translocation in AMD, 758 
Zip2 modulation of Nrf2-dependent antioxidant functions in, 1665 
Znt and ZIP zinc transporter expression in, 1221 (erratum, 3811) 
Retinal prosthesis, effect of implant location on pursuit eye movements, 3933 
Retinal thickness measurements 
OCT vs. fundus photography in diabetic macular edema, 1745 
reliability of, 2627 
Retinal vessels 
caliber changes after intravitreal triamcinolone for diabetic macular edema, 4707 
cardiovascular risk factors for retinal vein occlusion, 4297 
computerized analysis of vessel width and tortuosity in premature infants, 3577 
CRP-induced retinal vascular dysfunction (pig), 2053 
effect of aging on retinal artery blood column diameter, 2094 
effect of dorzolamide on retinal oxygen tension in BRVO (pig), 1136 
effects of triamcinolone acetonide on leukocyte dynamics in rat retinal microcirculation, 2127 
erythrocyte dynamics in retinal capillaries and choriocapillaris (monkey), 5510 
ethnic variability in caliber of, 1362 
NMDA relaxation of porcine retinal arterioles via adenosine receptors, 4590 
phase-contrast OCT of transverse flows in mouse retina and choroid, 5055 
relationship of retinal vessel diameter parameters in 6-year-olds, 2403 
retinal arteriolar and middle cerebral artery responses to hypercarbic/hyperoxic stimuli, 5503 
retinal arteriolar hemodynamic response to hyperoxia and glucose in diabetic retinopathy, 699 
role of NADPH oxidase in inflammation of, 3139 
sildenafil-induced retinal arteriolar dilation, 720 
Singapore Malay Eye Study, retinal vessel caliber, blood pressure, and cardiovascular risk factors in Asian population, 1784 
vascular narrowing in Asian eyes with glaucoma, 5397 
Retinitis pigmentosa (RP) 
allelic copy number variation in FSCN2 gene, 3799 
aqueous humor levels of VEGF in, 3499 
CERKL mutations and associated phenotypes in autosomal recessive RP, 2709 
correlation between macular volume and focal macular ERG in, 3551 
disease course of autosomal recessive RP patients with USH2A mutations, 5532 
effect of peripheral visual field loss on representations of space, 2765 
long-term follow-up of RP patients with multifocal ERG, 4664 
monitoring visual field defects by quantitative OCT, 3617 
protective effects of proinsulin in mouse model of, 4188 
retinal structure in human RP caused by Rhodopsin mutations, 1580 
RLBP1 and CAIV mutations in Bothnia dystrophy, 3172 
RNA expression atlas of RP genes in human and mouse retina, 2330 
RNFL analysis in RP patients using Fourier-domain OCT, 3525 
tauroursodeoxycholic acid preservation of photoreceptors in rd10 mice through postnatal day 30, 2148 
visual acuity related to parafoveal retinal thickness in patients with RP and macular cysts, 4568 
Retinoblastoma 
basic fibroblast growth factor in retinoblastoma progression and survival (mouse), 5215 
effects of verteporfin PDT on retinoblastoma cell lines, 3158 
subconjunctival topotecan in fibrin sealant in (mouse), 490 
targeting hypoxia as novel treatment for (mouse), 2799 
Retinol, antioxidants and cataract in North Indian population, 3328 
Retinol dehydrogenases RDH11 and RDH12, in mouse retina, 1071 
Retinopathy of prematurity (ROP) 
cone ERG in, 814 
OCT of foveal fine structure in, 2061 
ocular growth and refractive error development in, 5199 
oxygen-induced neovascularization independent of VEGF in rat model, 1591 
plus disease in: composite images, 4064 
understanding retinopathy through ROP (Friedenwald Lecture), 5177 
VEGF antibody decreases tortuosity in rat model, 3107 
Retinoschisin, circadian regulation in chick retina, 1615 
Retinoschisis, synaptic pathology in retinoschisis knockout mouse retina and modification by gene therapy, 3677 
Retinotopic mapping of primary visual cortex, effect of age and fixation instability on, 3734 
Rheumatoid arthritis, corneal involvement in, 560 
Rho 
Rho/ROCK in corneal epithelial cell cycle regulation, 175 
RhoA and synaptic plasticity of salamander photoreceptors, 4177 
RhoA/ROCK and ERK1/2 in cornea, 4982 
role in corneal epithelial wound healing, 900 
Rhodamine 6G, toxicity in rat retina, 2120 
Rhodopsin 
cones in rhodopsin mutant P23H-3 retina (rat), 1116 
misfolded, screening for pharmacologic chaperones of, 3224 
multifocal ERG in rhodopsin P347L transgenic pigs, 2208 
novel mutation in autosomal dominant congenital stationary night blindness, 4105 
retinal structure in human RP caused by Rhodopsin mutations, 1580 
Riboflavin/UVA combination treatment, antimicrobial efficacy of, 3402 
Rituximab, efficacy of intravitreal and intracerebral injections in lymphoma (mice), 4738 
Rods. See Photoreceptors 
Rotterdam Study, cataract surgery and risk of AMD, 4795 
RPE65 mutations 
novel hypomorphic mutation, 5235 
photoreceptor layer topography in children with Leber congenital amaurosis due to, 4573 
S
Saccadic eye movements 
fMRI study of eye movement control in AMD, 1728 
relationship between upper lid saccades and pursuit, 2444 
saccade dynamics and saccadic adaptation, 604 
Safety of intravitreal infliximab (rabbit), 1151 
Saffron supplement and retinal stress (rat), 1254 
Salisbury Eye Evaluation Project, racial and other risk factors for AMD, 2395 
Satellite cells in medial rectus muscles in strabismus, 215 
Scanning laser polarimetry (SLP) 
in AMD, 2661 
analysis of atypical SLP patterns by polarization-sensitive OCT, 5366 
impact of diabetic retinopathy on quantitative RNFL measurement and glaucoma screening, 687 
longitudinal variability of optic disc and RNFL measurements, 4886 
Sclera 
immunochemical localization of keratan sulfate proteoglycans in, 2424 
MMP-2 expression in melanoma-associated spongiform scleropathy, 2806 
scleral hydraulic conductivity and macromolecular diffusion in uveal effusion syndrome, 5033 
structural factors that mediate scleral stiffness (pig), 4232 
transscleral albumin permeability, 4041 
Scleral buckling, biodegradable collagen–glycosaminoglycan polymer for (rabbit), 2673 
Secretoglobins in rabbit lacrimal glands, 2856 
SEE Project, motion-detection threshold and measures of balance in older adults, 5257 
D-Serine, cell communication mechanisms in vertebrate retina (Proctor Lecture), 5184 
Serum amyloid A in glaucoma, 1916 
Sex steroids, in regulation of meibomian gland gene expression (mouse), 1797 
Shihpai Eye Study, prevalence and risk factors of AMD in elderly Chinese population, 3126 
Sialoadhesin expression in degenerating retinas after transplantation (mouse), 5602 
Sigma-1 receptor regulation of voltage-gated calcium channels, 4993 
Signal transduction 
β2-adrenergic receptor signaling–mediated corneal epithelial wound repair (mouse), 1857 
diadenosine polyphosphate recruits RhoA/ROCK and ERK1/2 in cornea, 4982 
IGF-1R/PI3K/AKT signaling in rod outer segments, 4765 
JNK-paxillin signaling pathway in corneal epithelial cell wound healing, 125 
NFI regulation of α6 integrin gene during corneal wound healing, 3758 
P2Y receptor subtypes regulate calcium signaling in RPE, 350 
PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in RPE, 1671 
PI3K/Akt signaling in uveal melanoma cell migration, 497 
Rho/ROCK in corneal epithelial cell cycle regulation, 175 
RhoA and synaptic plasticity of salamander photoreceptors, 4177 
Sildenafil-induced retinal arteriolar dilation, 720 
Singapore Malay Eye Study 
prevalence and types of glaucoma in Malay people, 3846 
retinal vessel caliber, blood pressure, and cardiovascular risk factors in Asian population, 1784 
visual impairment, causes of vision loss, and falls, 528 (erratum, 1298) 
Skew deviation, Listing’s law in patients with, 204 
Smith, Lois E. H., 2008 recipient of Friedenwald Award, 5175 
Smoking 
AMD, CFH, and, 2357 
effects of benzo(e)pyrene on RPE cells, 5111 
Soft tissue volumes of orbit, calculation of, 1758 
Soluble gp130 in uveitis aqueous humor, 3988 
Somatostatin 
neuroprotective effects in rat retina, 3081 
protection against retinal ischemia (rat), 342 
nonpeptide somatostatin receptor agonists target ocular neovascularization, 5094 
Spectacles 
acceptance among rural Chinese children, 2895 
effect of progressive addition lenses on myopia progression in Japanese children, 2781 
SPRR1B, as biomarker for squamous metaplasia in dry eye disease, 34 
Squamous metaplasia 
of human limbal epithelium, 154 
SPRR1B as biomarker for, in dry eye disease, 34 
Stakel, evaluation of new photosensitizer for PDT (rabbit and rat), 1633 
Stargardt disease, retinal dysfunction in patients and carrier relatives, 1191 
Stat6-independent inflammation of IκBζ−/− mice, 3387 
Statins 
HSP expression and RGC survival after retinal ischemia/reperfusion modulated by (rat), 4971 
protection against diabetic retinopathy mediated by, 3131 
Statistics, MNREAD–nonlinear mixed-effects modeling, 828 
Stem cells 
cornea limbal stem/progenitor cell transfection in organ culture model, 3395 
differentiation and production of action potentials by embryonic rat retina stem cells, 5144 
engrafted chicken neural tube–derived stem cells support axonal regeneration in rat optic nerve, 3513 
human Müller stem cell transplantation in rat glaucoma, 3449 
induction of photoreceptor phenotype by exogenous Crx expression in mouse retinal stem cells, 429 
retinal explant culture system as stem cell transplantation model, 3503 
separation of two populations of mouse limbal stem cells, 3903 
Stereo disc photographs, automated assessment of optic nerve head on, 2512 
Stereopsis, and quality of life in elderly women with cataracts, 1 
Stevens-Johnson syndrome with ocular surface complications, IL13/IL-4R gene polymorphisms in, 1809 
Strabismus 
activated satellite cells in medial rectus muscles in, 215 
color and motion VEPs in strabismic amblyopia, 4418 
duration of binocular decorrelation and latent nystagmus in strabismic monkeys, 1872 
Listing’s law in patients with skew deviation, 204 
myogenic growth factors decrease EOM force generation (rabbit), 221 
ocular torsion and cyclovertical strabismus (Weisenfeld Lecture), 847 
paclitaxel-releasing polytetrafluoroethylene/polylactide-co-glycolide laminate after strabismus surgery (rabbit), 5340 
temporal instability in amblyopic vision, 3940 
Streptococcus pneumoniae keratitis, passive immunization with pneumolysin antiserum (rabbit), 290 
Stress effects in infantile nystagmus syndrome, 2977 
Substance P 
apoptosis after Pseudomonas aeruginosa keratitis delayed by (mouse), 4458 
susceptibility to Pseudomonas aeruginosa keratitis promoted by (mouse), 1502 
Sulforaphane protection of RPE cells against oxidative stress, 2606 
Superior oblique palsy 
effect on vertical pursuit in monkeys, 3927 
and torsional optokinetic nystagmus (monkey), 1421 
Sydney Childhood Eye Study 
ethnic variability in retinal vessel caliber, 1362 
OCT study of retinal and optic disc findings in adolescents, 4328 
Syndromic choroideremia, 4096 
System N glutamine transporters in RGCs, 5151 
T
T cells 
dysfunction of CD4+CD25high regulatory T cells in Vogt-Koyanagi-Harada syndrome, 3475 
modulation of T cell responses by B subunit of E. coli heat-labile enterotoxin in EAU (mouse), 4008 
protective effects of CD1d-reactive invariant NK cells in corneal inflammation (mouse), 105 
reactivation of uveitogenic T cells by retinal astrocytes (mouse), 282 
regulatory T cells in EAU (rat), 3999 
suppression of ocular surface inflammation by expanded regulatory T cells (mouse), 5434 
Tauroursodeoxycholic acid, preservation of photoreceptors in rd10 mice through postnatal day 30, 2148 
TCF8 in Fuchs endothelial corneal dystrophy, 184 
Tears. See also Dry eye disease 
adsorption of tear film lipids to silicone hydrogels, 120 
degradation of secretory IgA in tears in P. aeruginosa keratitis, 4939 
lipid composition of human meibum and tears, 3779 
rheology of tear film lipid layer in normal and dry eyes, 5319 
Telangiectasia, macular, National Eye Institute Visual Function Questionnaire in, 4340 
Telmisartan, inhibition of neovascularization by (mouse), 4370 
TEM7 in fibrovascular membranes in proliferative diabetic retinopathy, 3151 
Temperature and atmospheric pressure influences on IOP, 5392 
Temporal instability in amblyopic vision, 3940 
TGIF as candidate gene for myopia, 49 
Thioltransferase deletion, effect on cellular sensitivity to oxidative stress in lens epithelial cells (mouse), 4497 
Thioredoxin 1 
protective effects of thioredoxins 1 and 2 in RGCs after optic nerve transection (rat), 3535 
suppression of choroidal neovascularization by interaction with complement factor H (mouse), 5118 
Thrombin, blebbistatin prevention of inhibitory effects of thrombin on intercellular calcium wave propagation, 4816 
Thyroid eye disease 
association of CTLA-4 and IL-13 gene polymorphisms with Graves’ disease and ophthalmopathy in Chinese children, 2409 
lysosome-related gene regulation in orbital fat in Graves’ ophthalmopathy, 4760 
Thyroid hormone 
required for cone opsin expression during retinal development (mouse), 2039 
thyroxine effects on embryonic chick corneal innervation, 139 
Tie-2, in pericyte survival and recruitment in diabetic retinopathy, 2163 
Timolol, effects of timolol-dorzolamide fixed combination vs. latanoprost on circadian diastolic ocular perfusion pressure in glaucoma, 4226 
Timor-Leste vision-specific quality-of-life questionnaire, 4284 
Tissue engineering 
artificial cornea construction from collagen–chondroitin sulfate foams and human cell cultures, 5325 
human tissue–engineered model of corneal wound healing, 1376 
innervation of recombinant human collagen-based corneal substitutes, 3895 
recombinant human collagen-based corneal substitutes for implantation, 3887 
Tissue inhibitors of matrix metalloproteinases (TIMPs), choroidal vessel abnormalities in mice lacking TIMP-3, 2813 
Tissue plasminogen activator, recombinant (rtPA), toxic effects of rtPA on cultured corneal endothelial cells, 1392 
Tissue release from a vibrating instrument, 1629 
Tissue transglutaminase expression in glaucomatous trabecular tissue, 622 
Toll-like receptors (TLR) 
AMD and polymorphisms of, 1652 
TLR4 in AMD, 364 
TLR4 polymorphisms and normal tension glaucoma, 4453 
Tonometry, IOP in preterm infants, 87 
Topotecan, subconjunctival, in fibrin sealant in murine retinoblastoma, 490 
Toxoplasmic retinochoroiditis, IL-10 polymorphism in, 1979 
Trabecular meshwork (TM) 
activation of store-operated Ca2+ channels in TM cells, 677 
effects on substrate rigidity on, 262 
gene expression profiles of human TM cells induced by triamcinolone and dexamethasone, 1886 
interactions between TM cells and lens epithelial cells in infantile aphakic glaucoma, 3981 
mitochondrial complex I defect in primary open-angle glaucoma TM cells, 1447 
mitochondrial defects and dysfunction in calcium regulation in glaucomatous TM cells, 4912 
nitrotyrosine expression and oxidative consequences in TM of glaucoma patients, 2506 
oxidative stress-induced alterations in lysosomal function in porcine TM cells, 3961 
pharmacologic inhibition of GGTase-I and aqueous humor outflow through, 2464 
podosome- or invadopodia-like structures for focal TM ECM turnover, 5353 
prostaglandin analogue reduction of oxidative stress in, 4872 
response of human TM cells to topographic cues on nanoscale level, 629 
tissue transglutaminase expression in glaucomatous trabecular tissue, 622 
Transcranial magnetic stimulation (TMS), study of posterior parietal cortex effects on binocular coordination, 230 
Transforming growth factor-β (TGF-β) 
effect of TGF-β2 in human optic nerve astrocytes, 1464 
EGF synergism with TGF-β1 in keratocyte differentiation, 2936 
matrix contraction mediated by, 650 
oxidative stress and TGF-β2–induced HSP27 expression in optic nerve head astrocytes, 5403 
Transient receptor potential vanilloid-1 receptor (TRPV1), modulation of IL-6 and NFκB with pressure (mouse), 3004 
Transplantation 
autologous partial thickness RPE-choroid transplantation (rabbit), 3185 
effect of amniotic membrane transplantation on healing of bacterial keratitis (rat), 163 
human Müller stem cell transplantation in rat glaucoma, 3449 
improved corneal graft survival due to ZK 261991-blocked angiogenesis, 1836 
innervation of tissue-engineered recombinant human collagen-based corneal substitutes, 3895 
lack of IFN-γ synthesis in aqueous humor during corneal graft rejection and suppressed NO production by macrophages (rat), 4923 
microperimetry after autologous RPE-choroid graft in macular dystrophy, 3143 
rabbit model of RPE transplantation, 4115 
rescue in RCS rats after late-stage RPE transplantation, 416 
retinal explant culture system as stem cell transplantation model, 3503 
tissue-engineered recombinant human collagen-based corneal substitutes for implantation, 3887 
Trefoil factor 1 (TFF1), anti-apoptotic effects in conjunctival cells, 3790 
Triamcinolone 
effects on leukocyte dynamics in rat retinal microcirculation, 2127 
enhancement of intraocular gene expression after adenoviral delivery (mouse), 399 
gene expression profiles of human TM cells induced by dexamethasone and, 1886 
inhibition of angiogenesis, 1184 
pharmacokinetics of intraocular drug delivery of Oregon Green–labeled triamcinolone by subtenon injection (rabbit), 4506 
protective effect against photoreceptor apoptosis in rabbit subretinal hemorrhage, 4071 
retinal vascular caliber changes after intravitreal triamcinolone for diabetic macular edema, 4707 
Tumor necrosis factor-α (TNF-α) 
delayed disruption of barrier function in cultured corneal epithelial cells induced by, 565 
deleterious role in retinal ischemia–reperfusion injury, 3605 
in pathogenesis of Bacillus cereus endophthalmitis (mouse), 4482 
regulation of TNFR1 in conjunctival epithelial cells, 3992 
Tumors 
lymphoma 
efficacy of intravitreal and intracerebral rituximab injections in (mice), 4738 
incidence of ophthalmic lymphoma in Denmark, 1980–2005, 3283 
OCT of RNFL thickness in prediction of visual recovery after parachiasmal tumor surgery, 1879 
retinoblastoma 
basic fibroblast growth factor in retinoblastoma progression and survival (mouse), 5215 
effects of verteporfin PDT on retinoblastoma cell lines, 3158 
subconjunctival topotecan in fibrin sealant in (mouse), 490 
targeting hypoxia as novel treatment for (mouse), 2799 
uveal melanoma 
B-RAF mutations in, 23 
chemokine receptor expression by, 636 
early oncogenic mutations in GNAQ in, 5230 
functional PD-L1 expression by, 2518 
gene expression profiling in, 4254 
high-frequency ultrasound of choroidal melanoma xenograft volume (rat), 16 
HSP90 inhibition in, 2348 
monosomy of chromosome 3 and inflammatory phenotype in, 505 
PI3K/Akt signaling in cell migration in, 497 
picropodophyllin-inhibited growth of, 2337 
RASEF as tumor-suppressor gene in, 1291 
resveratrol inhibition of tumor growth, 1299 
size overlap between benign melanocytic choroidal nevi and, 2823 
Twin studies 
Genes in Myopia Twin Study 
adult-onset myopia, 3324 
dominant genetic effects on corneal astigmatism, 1339 
role of educational attainment in refraction, 534 
shared genes in refraction and axial length, 4336 
Guangzhou Twin Eye Study 
heritability of anterior chamber depth in Chinese, 81 
heritability of central corneal thickness in Chinese, 4303 
heritability of iridotrabecular angle width in Chinese children, 1356 
heritability of optic disc and cup in Chinese, 1350 
shared genetic determinant of axial length, anterior chamber depth, and angle opening distance, 4790 
heritability of optic disc parameters, 77 
Tyrosine kinase inhibitors, improved corneal graft survival due to ZK 261991-blocked angiogenesis, 1836 
U
UBE2E3 required for proliferation of RPE cells, 5611 
Ubiquitination pathway for p27 degradation in corneal endothelial cells, 189 
Ultrasonography, high-frequency ultrasound of choroidal melanoma xenograft volume (rat), 16 
Ultraviolet (UV) radiation 
antimicrobial efficacy of riboflavin/UVA combination treatment, 3402 
and MMPs in ocular surface squamous neoplasia, 5295 
Unc119, interaction with CaBP4 in photoreceptors (mouse), 2366 
Urban environment and myopia in Australian children, 3858 
USH2A gene, disease course of autosomal recessive RP patients with mutations of, 5532 
Usher syndrome III, retinal disease due to clarin-1 mutations, 2651 
Uveal effusion syndrome, scleral hydraulic conductivity and macromolecular diffusion in, 5033 
Uveal melanoma 
B-RAF mutations in, 23 
chemokine receptor expression by, 636 
early oncogenic mutations in GNAQ in, 5230 
functional PD-L1 expression by, 2518 
gene expression profiling in, 4254 
high-frequency ultrasound of choroidal melanoma xenograft volume (rat), 16 
HSP90 inhibition in, 2348 
monosomy of chromosome 3 and inflammatory phenotype in, 505 
PI3K/Akt signaling in cell migration in, 497 
picropodophyllin-inhibited growth of, 2337 
RASEF as tumor-suppressor gene in, 1291 
resveratrol inhibition of tumor growth, 1299 
size overlap between benign melanocytic choroidal nevi and, 2823 
Uveitis 
abnormal cellular reactivity to microbial antigens in, 2526 
anti-crystallin seroreactivity in, 4476 
clinical time-course of experimental autoimmune uveoretinitis (mouse), 5458 
αA-crystallin–associated photoreceptor protection in experimental uveitis (mouse), 1161 
dysfunction of CD4+CD25high regulatory T cells in Vogt-Koyanagi-Harada syndrome, 3475 
endotoxin-induced, anti-inflammatory effects of C. longa and B. aristata in (rabbit), 4036 
experimental autoimmune (EAU) 
gene expression in rats that are susceptible or resistant to, 1957 
mitochondrial oxidative DNA damage in (rat), 3299 
modulation of T cell responses by B subunit of E. coli heat-labile enterotoxin in (mouse), 4008 
new pathogenic epitopes of IRBP in (mouse), 1946 
reactivation of uveitogenic T cells by retinal astrocytes (mouse), 282 
regulatory T cells in (rat), 3999 
glucosamine inhibition of endotoxin-induced uveitis (rat), 5441 
Il-23 and IL-17 in Behçet disease with active uveitis, 3058 
leptospiral, endotoxin as cause of, 5419 
neutrophil chemotaxis and IL-10 expression in tolerance of endotoxin-induced uveitis (rat), 5450 
NOD2 in murine muramyl dipeptide–induced uveitis, 1518 
soluble gp130 in uveitis aqueous humor, 3988 
V
Vascular endothelial growth factor (VEGF) 
aqueous humor levels of VEGF in RP, 3499 
effects of anti–VEGF-A monoclonal antibody on murine choroidal neovascularization, 1178 
induction of MEF2C in endothelial cells by, 3640 
interaction between bevacizumab and murine VEGF-A, 522 
mediation of corneal nerve repair by, 3870 
murine model of Bruch membrane lipoidal degeneration and VEGF164 detection, 390 
picropodophyllin inhibition of (mouse), 2620 
in ROP (Friedenwald Lecture), 5177 
VEGF antibody decreases tortuosity in rat ROP model, 3107 
VEGF polymorphisms and severity of diabetic retinopathy, 3611 
VEGF165 inhibition enhances PDT efficacy in ocular neovascularization (mouse), 662 
Vascular endothelial growth factor receptor 2 (VEGFR2) 
suppression of choroidal neovascularization by vaccine derived from (mouse), 2143 
suppression of corneal neovascularization by dendritic cell immunization against (mouse), 2172 
Vasculature. See also Endothelium; Neovascularization 
advanced glycation impairment of vascular repair by endothelial progenitor cells, 1232 
cardiovascular risk factors for retinal vein occlusion, 4297 
choroidal vessel abnormalities in mice lacking TIMP-3, 2813 
computerized analysis of retinal vessel width and tortuosity in premature infants, 3577 
CRP-induced retinal vascular dysfunction (pig), 2053 
cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells, 1242 
effect of aging on retinal artery blood column diameter, 2094 
effect of dorzolamide on retinal oxygen tension in BRVO (pig), 1136 
erythrocyte dynamics in retinal capillaries and choriocapillaris (monkey), 5510 
ethnic variability in retinal vessel caliber, 1362 
neuronal NO in lactate-induced vasodilation (minipig), 5060 
NMDA relaxation of porcine retinal arterioles via adenosine receptors, 4590 
phase-contrast OCT of transverse flows in mouse retina and choroid, 5055 
polypoidal choroidal vasculopathy, 4729 
relationship of retinal vessel diameter parameters in 6-year-olds, 2403 
retinal arteriolar and middle cerebral artery responses to hypercarbic/hyperoxic stimuli, 5503 
retinal arteriolar hemodynamic response to hyperoxia and glucose in diabetic retinopathy, 699 
retinal Frizzled-5 in regulation of hyaloid vitreous vasculature development (mouse), 5561 
retinal vascular caliber changes after intravitreal triamcinolone for diabetic macular edema, 4707 
retinal vascular narrowing in Asian eyes with glaucoma, 5397 
retinal vessel caliber, blood pressure, and cardiovascular risk factors in Asian population, 1784 
role of NADPH oxidase in retinal vascular inflammation, 3139 
sildenafil-induced retinal arteriolar dilation, 720 
triamcinolone acetonide inhibition of angiogenesis, 1184 
vascular precursors in developing human retina, 2178 
Vasoactive intestinal peptide (VIP), in maintenance of corneal endothelial differentiation state, 3491 
Versican and fibrillin-1 form hyaluronan-binding complex in ciliary body, 2870 
Verteporfin, effects on retinoblastoma cell lines, 3158 
Very-low-density lipoprotein receptor (VLDLR), retinal expression and neovascularization in knockout mouse model of retinal angiomatous proliferation, 407 
Vimentin, abnormal reactivity of Müller cells after retinal detachment in mice deficient in GFAP and, 3659 
Viscosity and elasticity effects on hysteresis, 3919 
Vision impairment/loss 
assessing effect on mortality through multiple health pathways, 3318 
effect of cognitive and vision loss on topography of attentional visual field, 4672 
falls and, 528 (erratum, 1298) 
functional vision in diabetic low-vision patients, 4051 
impact of glaucoma, lens opacities, and cataract surgery on visual functioning and quality of life, 1333 
prevalence and causes of functional low vision in Pakistan National Blindness and Visual Impairment Survey, 887 
prevalence and causes of functional low vision in school-age children, 877 
visual impairment in school children in Brazil, 4308 
visual sensory and motor deficits in children with cerebral palsy, 572 
Vision testing for inherited retinal disease (dog), 3568 
Visual acuity 
corneal vertex vs. central pupil references with aberration-free ablation and LASIK, 5287 
long-term vision rescue by human neural progenitors in rat model of photoreceptor degeneration, 3201 
and myopia in rural Chinese children, 2888 
National Eye Institute Visual Function Questionnaire in Macular Telangiectasia Project, 4340 
OCT of RNFL thickness in prediction of visual recovery after parachiasmal tumor surgery, 1879 
optical quality of eyes with normal and excellent vision, 4688 
and quality of life in elderly women with cataracts, 1 
rapid acuity assessment using VEPs, 438 
relation to parafoveal retinal thickness in patients with RP and macular cysts, 4568 
repeatability of visual acuity scores in AMD, 4347 
Timor-Leste vision-specific quality-of-life questionnaire, 4284 
uniformity of visual acuity measures in published studies, 4321 
visual outcome after RPE–choroid translocation in AMD, 758 
visual search and pattern-related visual stress, 4210 
Visual evoked potentials (VEPs) 
autoimmune optic neuritis in Marmoset monkeys, 3707 
color and motion VEPs in strabismic amblyopia, 4418 
effect of methylprednisolone on RGCs and visual function after ocular ischemia (rat), 5003 
in identification of human albinism, 238 
of optic nerve projections in human carriers of oculocutaneous albinism type 1a, 2756 
in primate model of NAION, 2985 
quantification of ischemic damage in rat retina, 1056 
rapid acuity assessment using, 438 
Visual field defects 
effect on representations of space, 2765 
estimating rate of progression in open-angle glaucoma, 66 
glaucoma and fitness to drive, 2449 
nitrotyrosine expression and oxidative consequences in TM of glaucoma patients, 2506 
resolution visual fields in children surgically treated for congenital cataract, 3730 
in RP, monitoring by quantitative OCT, 3617 
Visual phenotype of Rpe65rd12 and rd/rd mice, 2737 
Visual search and pattern-related visual stress, 4210 
Vitamin A supplementation, lipofuscin pigments in RPE of abca4−/− mice after, 3821 
Vitamin C, antioxidants and cataract in North Indian population, 3328 
Vitrectomy, endoscopic, in keratoprosthesis exchange (rabbit), 4407 
Vitreoretinal interface, collagen distribution in, 4089 
Vitreoretinopathy, proliferative, plasmin in vitreous processing of PDGF-C in, 42 
Vitreous fluid abnormalities, amelioration in diabetes by inhibitor of albumin glycation (rat), 5089 
Vogt-Koyanagi-Harada syndrome, dysfunction of CD4+CD25high regulatory T cells in, 3475 
W
Waldenström’s macroglobulinemia, effect of plasmapheresis on hyperviscosity-related retinopathy and retinal hemodynamics in, 1157 
Water, free and bound, in normal and cataractous lenses, 1991 
WDR36 missense variants in glaucoma, 270 
Weisenfeld Lecture 
David L. Guyton, 2007 recipient of the Weisenfeld Award, 846 
ocular torsion reveals mechanisms of cyclovertical strabismus, 847 
Wound healing, corneal 
β2-adrenergic receptor signaling–mediated (mouse), 1857 
association of PTB-1B with c-Met receptor and modulation of (rabbit), 2927 
connexin43 knockdown in (rat), 93 
heme oxygenase-1 in (mouse), 3379 
human tissue–engineered model of, 1376 
independent of limbal stem cell influence, 5279 
in vivo confocal microscopic evaluation after Epi-Lasik, 2416 
JNK-paxillin signaling pathway in, 125 
NFI regulation of α6 integrin gene during, 3758 
in osteopontin-deficient mouse, 1367 
role of Rho in, 900 
X
Xichang Pediatric Refractive Error Study 
spectacle acceptance among rural Chinese children, 2895 
visual function and myopia in rural Chinese children, 2888 
Z
Zeaxanthin 
effect on retinal metabolic abnormalities in diabetic rats, 1645 
fundus reflectometry measurement of retinal lutein and, 5568 
lutein/zeaxanthin and omega-3 fatty acid supplementation in older adults, 3864 
Zeb1 mutant mouse model of posterior corneal dystrophy, 1843 
Zip2 modulation of Nrf2-dependent antioxidant functions in RPE, 1665 
ZK 261991-blocked angiogenesis, improved corneal graft survival due to, 1836 
Znt and ZIP zinc transporters, expression in RPE, 1221 (erratum, 3811) 
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