December 2012
Volume 53, Issue 13
Letters to the Editor  |   December 2012
Author Response: Pupil Dynamics and Response Amplitude: Only Size Matters
Author Notes
  • Department of Neuro-ophthalmology, National Hospital for Neurology & Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom. 
Investigative Ophthalmology & Visual Science December 2012, Vol.53, 8049. doi:
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      Fion D. Bremner; Author Response: Pupil Dynamics and Response Amplitude: Only Size Matters. Invest. Ophthalmol. Vis. Sci. 2012;53(13):8049.

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      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
I was not aware of these studies, but am indebted to Professor Maddess 1 for bringing to our attention these earlier publications by Semmlow and Stark. 2,3 These studies and mine 4 show that pupil dynamics are scaled according to response amplitude as an intrinsic property of the neuromuscular plant, and so provide no specific additional information about function in the optic nerves, a point that has not been appreciated in many of the publications on pupillometric evaluation of optic neuropathies over the last 40 years. 
Maddess T. Pupil dynamics and response amplitude: only size matters. Invest Ophthalmol Vis Sci . 2012;53:7644. [CrossRef] [PubMed]
Semmlow J Stark L. Pupil movements to light and accommodative stimulation: a comparative study. Vision Res . 1973;13:1087–1100. [CrossRef] [PubMed]
Semmlow J Hansmann D Stark L. Variation in pupillomotor responsiveness with mean pupil size. Vision Res . 1975;15:85–90. [CrossRef] [PubMed]
Bremner FD. Pupillometric evaluation of the dynamics of the pupillary response to a brief light stimulus in healthy subjects. Invest Ophthalmol Vis Sci . 2012;53:7343–7347. [CrossRef] [PubMed]

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