May 2011
Volume 52, Issue 6
Letters to the Editor  |   May 2011
Surface and Volume Changes in the Lens during Accommodation
Author Affiliations & Notes
  • Oscar A. Candia
    Mount Sinai School of Medicine, New York, New York.
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3698. doi:
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      Oscar A. Candia; Surface and Volume Changes in the Lens during Accommodation. Invest. Ophthalmol. Vis. Sci. 2011;52(6):3698. doi:

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      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
I was excited by the results presented in the excellent paper by Sheppard et al. 1 showing a 2.3% increase in lens volume and a decrease of 1.82% in surface during accommodation in human volunteers. I was very gratified that they acknowledged that we had predicted similar changes in human lens volume and surface based on mathematical modeling of human lens dimensions, using the Pappus theorem as well as our experimentally induced changes in lens dimensions of isolated cow lenses under conditions mimicking accommodation. 2,3  
Their acknowledgment of our work is especially gratifying for us because members of the “accommodation group” had received our findings and predictions with skepticism. I hope that the publication by Sheppard et al. serves to encourage a re-evaluation of the changes that occur during accommodation. 
However, there is a point of ours that was dismissed by the authors, who simply indicated that the changes in lens volume may be due to compression of the lens bag contents. They did not consider the possibility that the change in volume could be fluid exiting and re-entering the lens bag. The lens capsule is very permeable to water, as shown by numerous “osmotic” experiments. We have also recently shown a relationship between the osmotic and mechanical forces of accommodation. 4  
Could the authors comment as to why they did not consider our suggested interpretation to explain the volume changes in their publication? 
 Supported by NIH Grant EY000160.
Sheppard AL Evans CJ Singh KD Wolffsohn JS Dunne MC Davies LN . Three-dimensional magnetic resonance imaging of the phakic crystalline lens during accommodation. Invest Ophthalmol Vis Sci. 2011;52:3689–3697. [CrossRef] [PubMed]
Gerometta R Zamudio AC Escobar DP Candia OA . Volume change of the ocular lens during accommodation. Am J Physiol Cell Physiol. 2007;293(2):C797–C804. [CrossRef] [PubMed]
Zamudio AC Candia OA Kong CW Wu B Gerometta R . Surface change of the mammalian lens during accommodation. Am J Physiol Cell Physiol. 2008;294(6):C1430–C1435. [CrossRef] [PubMed]
Candia O Zamudio AC Alvarez LJ . Mechanical stretching forces oppose osmotic lens swelling. Exp Eye Res. 2010;91(3):472–474. [CrossRef] [PubMed]

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