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Victor T. Koh, Yih-Chung Tham, Carol Y. Cheung, Wan-Ling Wong, Mani Baskaran, Seang-Mei Saw, Tien Y. Wong, Tin Aung; Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(9):5853-5859. doi: 10.1167/iovs.12-10414.
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To determine the distribution, variation, and determinants of ganglion cell–inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT).
Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry. HD-OCT with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors.
The mean (±SD) age of study subjects was 52.84 ± 6.14 years, 50.1% were male, and all subjects had normal visual fields with no signs of glaucoma or glaucoma suspect. The mean overall, minimum, superior, and inferior GC-IPL thicknesses were 82.78 ± 7.01 μm, 79.67 ± 9.17 μm, 83.30 ± 7.89 μm, and 80.16 ± 8.31 μm, respectively. In multiple linear regression analysis, GC-IPL thickness was significantly associated with age (β = −0.202, P < 0.001), female sex (β = −2.367, P < 0.001), axial length (β = −1.279, P = 0.002), and mean peripapillary retinal nerve fiber layer (RNFL) thickness (β = 0.337, P < 0.001). IOP, central corneal thickness, disc area, serum glucose level, and history of diabetes mellitus had no significant influence on GC-IPL thickness.
Thinner GC-IPL was independently associated with older age, female sex, longer axial length, and thinner RNFL thickness. These factors should be taken into account when interpreting GC-IPL thickness measurements with HD-OCT for glaucoma assessment.
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