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Hehua Ye, Qi Zhang, Xiaohong Liu, Xuan Cai, Wenjing Yu, Siyi Yu, Tianyu Wang, Wuyi Lu, Xiang Li, Haiying Jin, Yiqian Hu, Xiaoli Kang, Peiquan Zhao; Prevalence of Age-Related Macular Degeneration in an Elderly Urban Chinese Population in China: The Jiangning Eye Study. Invest. Ophthalmol. Vis. Sci. 2014;55(10):6374-6380. doi: https://doi.org/10.1167/iovs.14-14899.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the prevalence of AMD in an elderly urban Chinese population in China.
A population-based, cross-sectional study was conducted using a cluster random sample of residents aged 50 years or older living in the Jiangning Road Subdistrict, Jing'an District, Shanghai, China. All participants underwent a standardized interview and comprehensive eye examinations, including digital retinal photography and spectral-domain optical coherence tomography (OCT) examinations of both eyes between November 2012 and February 2013. Trained graders assessed the presence and severity of AMD lesions based on a modified version of the Wisconsin Age-Related Maculopathy Grading System.
Of the 2044 subjects who participated (82.5% response rate), 2005 had fundus photographs and OCT results of sufficient quality for grading of AMD signs. Early and late AMD were present in 206 (10.3%) and 23 (1.1%) participants, respectively. After age standardization, the prevalence of early AMD in Chinese persons aged 50 years or older was 9.5% (95% confidence interval [CI], 8.2–10.8) and that of late AMD was 1.0% (95% CI, 0.5–1.5).
The prevalence of early and late AMD in this urban Chinese sample was higher than that reported in the Beijing and Handan studies. Age-related macular degeneration is highly prevalent among the elderly urban Chinese population in mainland China.
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