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Marcel N. Menke, Jens H. Kowal, Pascal Dufour, Ute E. Wolf-Schnurrbusch, Lala Ceklic, Carsten Framme, Sebastian Wolf; Retinal Layer Measurements After Successful Macula-Off Retinal Detachment Repair Using Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2014;55(10):6575-6579. doi: https://doi.org/10.1167/iovs.14-14412.
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Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair.
Optical coherence tomography scans of patients after successful macula-off RD repair were reanalyzed with a subsegmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had a follow-up period after surgery of up to 7 weeks (range, 21–49 days). In group 2, the follow-up period was >8 weeks (range, 60–438 days). Findings were compared to a group of age-matched healthy controls.
Correlation analysis showed a significant positive correlation between inner nuclear-outer plexiform layer (INL-OPL) thickness and time after surgery (P = 0.0212; r 2 = 0.1551). Similar results were found for the ellipsoid zone–retinal pigment epithelium complex (EZ-RPE) thickness (P = 0.005; r 2 = 0.2215). Ganglion cell-inner plexiform layer thickness (GCL-IPL) was negatively correlated with time after surgery (P = 0.0064; r 2 = 0.2101). For group comparison, the retinal nerve fiber layer in both groups was thicker compared to controls. The GCL-IPL showed significant thinning in group 2. The outer nuclear layer was significantly thinner in groups 1 and 2 compared to controls. The EZ-RPE complex was significantly thinner in groups 1 and 2 compared to controls. In addition, values in group 1 were significantly thinner than in group 2.
Optical coherence tomography retinal layer thickness measurements after successful macular-off RD repair revealed time-dependent thickness changes. Inner nuclear-outer plexiform layer thickness and EZ-RPE thickness was positively correlated with time after surgery. Ganglion cell-inner plexiform layer thickness was negatively correlated with time after surgery.
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