April 1967
Volume 6, Issue 2
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Articles  |   April 1967
Alcohol, Vasopressin, and Intraocular Pressure
Author Affiliations
  • ROLAND E. HOULE
    Massachusetts Eye and Ear Infirmary (Glaucoma Consultation Service), Howe Laboratory of Ophthalmology Boston, Mass.
  • W. MORTON GRANT
    Massachusetts Eye and Ear Infirmary (Glaucoma Consultation Service), Howe Laboratory of Ophthalmology Boston, Mass.
Investigative Ophthalmology & Visual Science April 1967, Vol.6, 145-154. doi:
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      ROLAND E. HOULE, W. MORTON GRANT; Alcohol, Vasopressin, and Intraocular Pressure. Invest. Ophthalmol. Vis. Sci. 1967;6(2):145-154.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Alcohol given orally or intravenously to patients reduced the pressure in glaucomatous eyes. The duration of pressure reduction was prolonged several hours by continuing administration. Vasopressin (antidiuretic hormone) 0.5 unit injected subcutaneously in patients with normal or abnormal posterior pituitary function did not influence the pressure of either normal or glaucomatous eyes, but it did antagonize the pressure-reducing effect of alcohol. Glaucoma was induced by repeated application of dexamethasone to one eye of a patient who had severe diabetes insipidus following removal of the pituitary. Alcohol lowered the pressure in this eye, with no possibility of antidiuretic hormone being implicated.

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