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ROLAND E. HOULE, W. MORTON GRANT; Alcohol, Vasopressin, and Intraocular Pressure. Invest. Ophthalmol. Vis. Sci. 1967;6(2):145-154.
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Alcohol given orally or intravenously to patients reduced the pressure in glaucomatous eyes. The duration of pressure reduction was prolonged several hours by continuing administration. Vasopressin (antidiuretic hormone) 0.5 unit injected subcutaneously in patients with normal or abnormal posterior pituitary function did not influence the pressure of either normal or glaucomatous eyes, but it did antagonize the pressure-reducing effect of alcohol. Glaucoma was induced by repeated application of dexamethasone to one eye of a patient who had severe diabetes insipidus following removal of the pituitary. Alcohol lowered the pressure in this eye, with no possibility of antidiuretic hormone being implicated.
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