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GEORGE H. BRESNICK; Oxygen-Induced Visual Cell Degeneration in the Rabbit. Invest. Ophthalmol. Vis. Sci. 1970;9(5):372-387.
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High oxygen concentrations induced visual cell degeneration in albino and pigmented rabbits. The most sensitive cells were located in the area centralis, a zone analogous to the human macula, and characterized by low glycogen content and rich choroidal blood supply. Electron microscopy demonstrated early pathological changes of intracellular membranes followed by total disorganization of visual cells, particularly those with rod-type synapses. DL-alphatocopherol acetate did not prevent visual cell damage.
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