March 1975
Volume 14, Issue 3
Articles  |   March 1975
Pathways for the response of the eye to injury.
Investigative Ophthalmology & Visual Science March 1975, Vol.14, 184-189. doi:
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      L M Jampol, A H Neufeld, M L Sears; Pathways for the response of the eye to injury.. Invest. Ophthalmol. Vis. Sci. 1975;14(3):184-189.

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      © ARVO (1962-2015); The Authors (2016-present)

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The role of a neural pathway in the disruption of the blood-aqueous barrier of the rabbit after two irritating stimuli, topical nitrogen mustard, and paracentesis, was studied. Retrobulbar anesthesia or section of the ophthalmic division of the trigeminal nerve decreased the breakdown of the blood-aqueous barrier, as measured by protein in the aqueous humor, after topical nitrogen mustard. Sensory denervation, accomplished with retrobulbar alcohol, virtually prevented the protein rise in the aqueous humor. Disruption of the blood-aqueous barrier after paracentesis, however, was not affected by retrobulbar anesthesia or alcohol denervation. Therefore, the increased protein in the aqueous humor after an irritative stimulus appears to be mediated by at least two pathways. The response to a stimulus such as nitrogen mustard depends on sensory innervation and is not mediated by prostaglandins to any important degree. The response to paracentesis does not require sensory innervation and appears to be mediated, at least in part, by prostaglandins.


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