June 1976
Volume 15, Issue 6
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Articles  |   June 1976
Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution.
Investigative Ophthalmology & Visual Science June 1976, Vol.15, 489-492. doi:https://doi.org/
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      I M Katz, W A Hubbard, A J Getson, A L Gould; Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution.. Invest. Ophthalmol. Vis. Sci. 1976;15(6):489-492. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Timolol ophthalmic solutions 0.5 per cent, 1.0 per cent, and 1.5 per cent lowered intraocular pressures significantly in normal human volunteers. Maximum lowering of the intraocular pressures was reached at two hours with the 0.5 per cent solution of timolol and at one hour with the 1.0 per cent and 1.5 per cent timolol ophthalmic solutions. The effect lasted the full seven hours of observations. No objective or subjective evidence of ocular irritation could be attributed to the drug. A single dose of timolol applied topically to the eyes of normal human volunteers had no effect on pupillary size, visual acuity, blood pressure, or pulse rate.

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