August 1976
Volume 15, Issue 8
Articles  |   August 1976
Ocular pathology induced by the suckling mouse cataract agent.
Investigative Ophthalmology & Visual Science August 1976, Vol.15, 640-647. doi:
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      R P Friedlaender, M F Barile, T Kuwabara, H F Clark; Ocular pathology induced by the suckling mouse cataract agent.. Invest. Ophthalmol. Vis. Sci. 1976;15(8):640-647.

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      © ARVO (1962-2015); The Authors (2016-present)

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The eye disease caused by SMCA may be best characterized as an endophthalmitis, with early retinitis followed by subsequent posterior uveitis. Pathologic features of lens included: proliferation and abnormal posterior extension of lens epithelium, increased accumulation of lens capsule material, and production of aberrant lens substance. Cataractous change appears to be secondary to intraocular inflammation. In addition to the above pattern, in roughly 20 per cent of all cases, 3 weeks after inoculation, lens capsule is destroyed giving rise to a foreign body granulomatous reaction.


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