September 1975
Volume 14, Issue 9
Articles  |   September 1975
Effects of lysophosphatidyl choline and phospholipase A on the lens.
Investigative Ophthalmology & Visual Science September 1975, Vol.14, 697-701. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      E Cotlier, M Baskin, L Kresca; Effects of lysophosphatidyl choline and phospholipase A on the lens.. Invest. Ophthalmol. Vis. Sci. 1975;14(9):697-701.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Lenses incubated for 24 or 63 hours in media containing either lysophosphatidyl choline or phospholipase A gained Na+ ions and water. Electrolyte imbalances and damage to lens fiber membranes occurred at lysophosphatidyl choline and phospholipase A concentrations of 7.5 mug per milliliter and 0.25 mug per milliliter, respectively. Intravitreal injection of 250 mug of lysophosphatidyl choline or 0.4 mug of phospholipase A induced posterior subcapsular cataracts which progressed to maturity only in the latter instance. This is the first demonstration of the cataractogenic effects of a naturally occurring aqueous humor phospholipid or its generating enzyme.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.