October 1976
Volume 15, Issue 10
Articles  |   October 1976
The corneal penetration of 6-aminohexanoic acid.
Investigative Ophthalmology & Visual Science October 1976, Vol.15, 857-860. doi:https://doi.org/
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R C Campbell, R W Neault, R F Brubaker; The corneal penetration of 6-aminohexanoic acid.. Invest. Ophthalmol. Vis. Sci. 1976;15(10):857-860. doi: https://doi.org/.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

6-Aminohexanoic acid is a potent antifibrinolytic agent with the ability to retard dissolution of fibrin clots. The corneal penetration of 6-aminohexanoic acid was measured to determine if therapeutic levels of the drug could be maintained in the anterior chamber by topical administration. The conjunctival sac to anterior chamber transfer coefficient was found to be 1.51 X 10-4 +/- 0.20 X 10-4 per minute and the corneal permeability found to be 3.46 X 10-7 +/- 0.46 X 10-7 cm. per second in the rhesus monkey eye. The results indicate that, to establish a therapeutic level in the aqueous humor, a high concentration of drug would have to be used with topical drop administration or a zero order delivery system must be used.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.