October 1976
Volume 15, Issue 10
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Articles  |   October 1976
The corneal penetration of 6-aminohexanoic acid.
Investigative Ophthalmology & Visual Science October 1976, Vol.15, 857-860. doi:https://doi.org/
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      R C Campbell, R W Neault, R F Brubaker; The corneal penetration of 6-aminohexanoic acid.. Invest. Ophthalmol. Vis. Sci. 1976;15(10):857-860. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

6-Aminohexanoic acid is a potent antifibrinolytic agent with the ability to retard dissolution of fibrin clots. The corneal penetration of 6-aminohexanoic acid was measured to determine if therapeutic levels of the drug could be maintained in the anterior chamber by topical administration. The conjunctival sac to anterior chamber transfer coefficient was found to be 1.51 X 10-4 +/- 0.20 X 10-4 per minute and the corneal permeability found to be 3.46 X 10-7 +/- 0.46 X 10-7 cm. per second in the rhesus monkey eye. The results indicate that, to establish a therapeutic level in the aqueous humor, a high concentration of drug would have to be used with topical drop administration or a zero order delivery system must be used.

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