December 1977
Volume 16, Issue 12
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Articles  |   December 1977
Biosynthesis of proteins by the retina. Inactivation by near-ultraviolet light and the effects of tryptophan, epinephrine, and catalase.
Investigative Ophthalmology & Visual Science December 1977, Vol.16, 1104-1109. doi:
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      Y Matuk, P Lou, J A Parker; Biosynthesis of proteins by the retina. Inactivation by near-ultraviolet light and the effects of tryptophan, epinephrine, and catalase.. Invest. Ophthalmol. Vis. Sci. 1977;16(12):1104-1109.

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Abstract

Postmitochondrial supernatant, cytosol, and microsomes were exposed to near-ultraviolet light and assayed for incorporation of (3H)leucine. The results indicate that near-ultraviolet light decreased the incorporation of radioactivity into the aminoacyl-tRNA fraction and into proteins. This effect depended on the wavelength of irradiation and the concentration of exposed protein. Tryptophan and epinephrine potentiated the effect of near-ultraviolet light, but catalase prevented this effect. Hydrogen peroxide decreased protein synthesis when it was added to unirradiated postmitochondrial supernatant. The results suggest that near-ultraviolet light would decrease protein synthesis by generating hydrogen peroxide from tryptophan and epinephrine.

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