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Abstract
(1) In owl monkeys, where no yellow staining of the media is present, there are clear-cut ophthalmoscopic and histologic differences in the lesions produced by equal amounts of argon green and blue light. (2) The yellow staining of the macula causes differences in lesion intensity and depth when different wavelengths are used for photocoagulation. (3) In humans the influence of age on this difference is apparent.