November 1978
Volume 17, Issue 11
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Articles  |   November 1978
Pigment epithelial windows and drusen: an animal model.
Investigative Ophthalmology & Visual Science November 1978, Vol.17, 1059-1068. doi:
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      B S Fine, R P Kwapien; Pigment epithelial windows and drusen: an animal model.. Invest. Ophthalmol. Vis. Sci. 1978;17(11):1059-1068.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Aging rhesus monkeys, both controls and those undergoing long-term administration of investigational oral contraceptive steroids, developed widespread hyperfluorescent dots at the posterior pole. The dots were considered to represent drusen. Histologic (including electron microscopic) study showed the "drusen" in some of the animals to be almost exclusively pigment epithelial windows produced by a lipoidal degeneration of the pigment epithelial cells. The experiment provided a fortuitous model for direct correlation of clinical and histologic observations of myriad uniform, tiny, depigmented, hyperfluorescent, nonleaking spots at the level of the retinal pigment epithelium.

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