January 1978
Volume 17, Issue 1
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Articles  |   January 1978
Quantitative verification of the existence of high molecular weight protein aggregates in the intact normal human lens by light-scattering spectroscopy.
Investigative Ophthalmology & Visual Science January 1978, Vol.17, 51-57. doi:
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      J A Jedziniak, D F Nicoli, H Baram, G B Benedek; Quantitative verification of the existence of high molecular weight protein aggregates in the intact normal human lens by light-scattering spectroscopy.. Invest. Ophthalmol. Vis. Sci. 1978;17(1):51-57.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The method of quasi-elastic light-scattering spectroscopy was used to establish quantitatively the concentration of high mmolecular weight (HMW) aggregates present in the normal human intact lens as a function of age. The concentration of HMW proteins increases monotonically with age. HMW proteins are absent in the infant lens, but represent 3% of the total soluble lens protein at age 60 years. The percent concentration of HMW proteins measured in intact lenses of various ages by quasi-elastic light scattering is in striking agreement with values determined biochemically.

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