January 1978
Volume 17, Issue 1
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Articles  |   January 1978
Antimuscarinic effects of stereoisomers of tropicamide on rabbit iris sphincter.
Investigative Ophthalmology & Visual Science January 1978, Vol.17, 65-68. doi:
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      P N Patil; Antimuscarinic effects of stereoisomers of tropicamide on rabbit iris sphincter.. Invest. Ophthalmol. Vis. Sci. 1978;17(1):65-68.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The antimuscarinic activity of optical isomers of tropicamide were compared on the isolated rabbit iris sphincter. The increasing concentrations of both the (--)- and (+)-isomer shifted the dose-response curve of carbachol to the right in a parallel fashion. The competitive reversible muscarinic blocking effects of both isomers were confirmed by pA2 plots. The pA2 values from the nonpigmented irides for (--)- and (+)-tropicamide were 7.88 and 6.18, respectively. Thus the (+)-isomer has only 1/50 the blocking activity of the (--)-isomer. Although both isomers are slightly less active in the pigmented iris, the activity difference between the isomers was high. From the nonpigmented iris, the blocking effect of the active (--)-tropicamide was readily reversed by washing, whereas reversal of this isomer's effect from the pigmented iris was relatively slow.

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