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M Tamai, P Teirstein, A Goldman, P O'Brien, G Chader; The pineal gland does not control rod outer segment shedding and phagocytosis in the rat retina and pigment epithelium.. Invest. Ophthalmol. Vis. Sci. 1978;17(6):558-562.
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Diurnal patterns of retinal outer segment shedding and phagocytosis by the pigment epithelium were examined in pinealectomized, superior-cervical-ganglionectomized, and sham-operated rats. Phagocytosis was quantitatively similar in all groups. Sharp increases in the number of large phagosomes were observed soon after lights were turned on in the tree sets of animals. Pinealectomized animals kept in constant darkness over a 24 hr period also exhibited normal shedding patterns. Our results suggest that the pineal does not exert a major influence on the daily rhythms of shedding and phagocytosis observed in the retina-pigment epithelium unit.
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