June 1978
Volume 17, Issue 6
Free
Articles  |   June 1978
Demonstration of tyrosinase in the adult bovine uveal tract and retinal pigment epithelium.
Investigative Ophthalmology & Visual Science June 1978, Vol.17, 511-514. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      T P Dryja, M O'Neil-Dryja, J M Pawelek, D M Albert; Demonstration of tyrosinase in the adult bovine uveal tract and retinal pigment epithelium.. Invest. Ophthalmol. Vis. Sci. 1978;17(6):511-514.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Modern techniques offer an opportunity for a more complete evaluation of melanin production in the uvea and retinal pigment epithelium (RPE). By measuring the release of tritium from tritiated tyrosine in homogenized samples of adult bovine RPE as well as iris and choroid, tyrosinase activity could be demonstrated in both the uveal tract and the RPE. Phenylthiourea, a specific tyrosinase inhibitor, markedly decreased tyrosinase activity, whereas 3-iodo-tyrosine, a tyrosine hydroxylase inhibitor, had no effect. These techniques indicate tyrosinase activity in the uveal tract and the RPE of adult cattle. This is the first biochemical demonstration of tyrosinase in adult RPE.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×