October 1980
Volume 19, Issue 10
Articles  |   October 1980
Vanadate and aqueous humor dynamics. Proctor Lecture.
Investigative Ophthalmology & Visual Science October 1980, Vol.19, 1156-1165. doi:
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      B Becker; Vanadate and aqueous humor dynamics. Proctor Lecture.. Invest. Ophthalmol. Vis. Sci. 1980;19(10):1156-1165.

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      © ARVO (1962-2015); The Authors (2016-present)

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Topical administration of 0.5% vanadate lowers intraocular pressure in monkey and rabbit eyes. This appears to be a consequence of a reduction in the rate of aqueous humor secretion, probably resulting from the inhibition of ciliary epithelium membrane. NaK ATPase. The ubiquitous vanadate and its interactions with catecholamines and ascorbate may play a role in regulating the sodium pump of the ciliary epithelium. Adrenergic blocking agents may also lower intraocular pressure by inhibiting the NaK ATPase of the ciliary epithelium.


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