November 1980
Volume 19, Issue 11
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Articles  |   November 1980
Effect of acyclovir on acute and latent herpes simplex virus infections in the rabbit.
Investigative Ophthalmology & Visual Science November 1980, Vol.19, 1336-1341. doi:
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      M D Trousdale, E C Dunkel, A B Nesburn; Effect of acyclovir on acute and latent herpes simplex virus infections in the rabbit.. Invest. Ophthalmol. Vis. Sci. 1980;19(11):1336-1341.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Acyclovir, a new potent antiviral drug, was used to treat herpes simplex virus (HSV) infection in the rabbit ocular model. Acyclovir (3% ointment) used topically one to five times a day on acute ocular HSV infection gave beneficial results as measured by a reduction in corneal involvement, conjunctivitis, iritis, and corneal clouding. Topical treatment did not prevent the establishment of latent HSV infection. Intravenous acyclovir used two times a day (50 mg/kg) on rabbits with latent HSV infection appeared to suppress HSV in the nervous system but did not eradicate established latent HSV infection.

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