October 1980
Volume 19, Issue 10
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Articles  |   October 1980
Reduction of intraocular pressure in glaucomatous dogs by a new cholinergic drug.
Investigative Ophthalmology & Visual Science October 1980, Vol.19, 1198-1203. doi:
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      C Y Chiou, J Trzeciakowski, K N Gelatt; Reduction of intraocular pressure in glaucomatous dogs by a new cholinergic drug.. Invest. Ophthalmol. Vis. Sci. 1980;19(10):1198-1203.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

N-Demethylated carbachol (DMC) was synthesized and analyzed for its ocular effects. DMC has been found to penetrate ocular tissue effectively. It has been shown to be free of acute toxic properties in rabbits and dogs at therapeutic doses and has been demonstrated to lower intraocular pressure of glaucomatous beagles without causing intense miosis. The effects of DMC and pilocarpine on outflow facility were compared in normal dogs. At the dose used in these experiments, both drugs affected outflow facility to a similar extent. It is concluded that DMC could be a potentially useful ocular hypotensive agent.

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