August 1980
Volume 19, Issue 8
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Articles  |   August 1980
Cyclic nucleotides vary by area in the retina and pigmented epithelium of the human and monkey.
Investigative Ophthalmology & Visual Science August 1980, Vol.19, 864-869. doi:
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      D A Newsome, R T Fletcher, G J Chader; Cyclic nucleotides vary by area in the retina and pigmented epithelium of the human and monkey.. Invest. Ophthalmol. Vis. Sci. 1980;19(8):864-869.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Cyclic GMP and cyclic AMP are present in lower concentrations in the central (macular) region of the neural retina of the human and monkey than in other areas. This pattern approximates the distribution of rod photoreceptor cells. Surprisingly, an inverse gradient of cyclic GMP concentration is observed in the pigmented epithelium. Levels in the central region are over fourfold higher than in cells in the periphery, offering the first evidence of biochemical differences in this embryologically uniform cell type.

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