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J R Hassell, D A Newsome, L M De Luca; Increased biosynthesis of specific glycoconjugates in rat corneal epithelium following treatment with vitamin A.. Invest. Ophthalmol. Vis. Sci. 1980;19(6):642-647.
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The biosynthesis of corneal epithelial proteins and glycoconjugates and their response to vitamin A were measured in vitamin A-deficient and normal rats. The synthesis of specific high-molecular-weight epithelial glycoconjugates was directly related to the levels of vitamin A administered. Protein synthesis, however, remained unaltered. Since vitamin A is known to reverse the keratinization process, the vitamin A-regulated high-molecular-weight glycoconjugates may play a role in modulating the expression of the keratinizing phenotype.
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