June 1980
Volume 19, Issue 6
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Articles  |   June 1980
Increased biosynthesis of specific glycoconjugates in rat corneal epithelium following treatment with vitamin A.
Investigative Ophthalmology & Visual Science June 1980, Vol.19, 642-647. doi:
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      J R Hassell, D A Newsome, L M De Luca; Increased biosynthesis of specific glycoconjugates in rat corneal epithelium following treatment with vitamin A.. Invest. Ophthalmol. Vis. Sci. 1980;19(6):642-647.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The biosynthesis of corneal epithelial proteins and glycoconjugates and their response to vitamin A were measured in vitamin A-deficient and normal rats. The synthesis of specific high-molecular-weight epithelial glycoconjugates was directly related to the levels of vitamin A administered. Protein synthesis, however, remained unaltered. Since vitamin A is known to reverse the keratinization process, the vitamin A-regulated high-molecular-weight glycoconjugates may play a role in modulating the expression of the keratinizing phenotype.

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