June 1980
Volume 19, Issue 6
Articles  |   June 1980
Participation of ocular tissues in systemic anaphylaxis.
Investigative Ophthalmology & Visual Science June 1980, Vol.19, 690-694. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M R Allansmith, K J Bloch, R S Baird, K J Sinclair; Participation of ocular tissues in systemic anaphylaxis.. Invest. Ophthalmol. Vis. Sci. 1980;19(6):690-694.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

The participation of ocular tissues was examined in two models of systemic anaphylaxis in the rat. Increased retention of radiolabeled rat serum albumin, which accompanies anaphylaxis, was the parameter measured. The production of IgE antibodies to egg albumin or worm antigen was stimulated by immunization with minute amounts of egg albumin and alum or by infection with Nippostrongylus brasiliensis. Intravenous administration of egg albumin or worm extract produced clinical signs of systemic anaphylaxis in the correspondingly immunized rats. Systemic anaphylaxis was accompanied by increased retention of radiolabeled rat serum albumin in the small intestine in both groups of rats. Significantly increased retention occurred in rat lid-conjunctivaorbital tissues of both groups and in globe tissues of the rats immunized with egg albumin. We concluded that the ocular tissues participated in systemic anaphylaxis.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.