June 1981
Volume 20, Issue 6
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Articles  |   June 1981
The effect of timolol maleate on the disruption of the blood-aqueous barrier in the rabbit eye.
Investigative Ophthalmology & Visual Science June 1981, Vol.20, 726-732. doi:
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      G Holmdahl, E Bengtsson; The effect of timolol maleate on the disruption of the blood-aqueous barrier in the rabbit eye.. Invest. Ophthalmol. Vis. Sci. 1981;20(6):726-732.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

A disruption of the blood-aqueous barrier in rabbit eyes was elicited by use of topical prostaglandin E2(PGE2), infrared irradiation of the iris, or by subcutaneous alpha-melanocyte-stimulating hormone (alpha-MSH). The aqueous flare provoked was measured quantitatively with a photoelectric instrument. The effect of the (topical) beta-adrenergic antagonist timolol maleate on the breakdown of the blood-aqueous barrier was tested. Timolol applied topically in very large doses had no effect on exogenously administered PGE2. However, even in a very small concentration applied topically, timolol reduced the flare response to both infrared irradiation and alpha-MSH. These results support the theory that the effect of alpha-MSH and infrared irradiation on the blood-aqueous barrier is dependent on intact beta-adrenergic receptor sites.

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