June 1981
Volume 20, Issue 6
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Articles  |   June 1981
In vitro contraction of the pupillary sphincter by substance P and its stable analogs.
Investigative Ophthalmology & Visual Science June 1981, Vol.20, 717-721. doi:
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      S Cohen, E Dusman, S Blumberg, V I Teichberg; In vitro contraction of the pupillary sphincter by substance P and its stable analogs.. Invest. Ophthalmol. Vis. Sci. 1981;20(6):717-721.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The effects of substance P and substance P analogs have been studied quantitatively by use of an isolated preparation of bovine pupillary sphincter muscle. Substance P contracts the pupillary sphincter in a dose-dependent manner with a value for median effective dose (ED50) of 1.0 X 10(-6) M. The effects of substance P result from its interaction with a specific receptor in the pupillary sphincter. These results strengthen the view that substance P is involved in the oculopupillary reflex.

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