June 1981
Volume 20, Issue 6
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Articles  |   June 1981
Inhibition of active transport of chloride and sodium by vanadate in the cornea.
Investigative Ophthalmology & Visual Science June 1981, Vol.20, 733-737. doi:
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      O A Candia, S M Podos; Inhibition of active transport of chloride and sodium by vanadate in the cornea.. Invest. Ophthalmol. Vis. Sci. 1981;20(6):733-737.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Vanadate, an inhibitor of (Na+ + K+)ATPase, also inhibits active transepithelial Na+ and Cl- transport (measured as short-circuit current) in the isolated cornea in concentrations of 10(-4)M to 10(-3)M. The disulfonic stilbene, DIDS, does not affect the short-circuit current per se, but it prevents the inhibitory effect of vanadate on Na+ and Cl- transport. Since vanadate acts in other systems from the cytoplasmic side, it is postulated that DIDS interferes with vanadate penetration into the epithelial cells. These results also strengthen the notion of a Na-Cl co-transport system in the corneal epithelium.

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