June 1981
Volume 20, Issue 6
Free
Articles  |   June 1981
Additivity and repair of actinic retinal lesions.
Investigative Ophthalmology & Visual Science June 1981, Vol.20, 803-807. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      G A Griess, M F Blankenstein; Additivity and repair of actinic retinal lesions.. Invest. Ophthalmol. Vis. Sci. 1981;20(6):803-807.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Extensive exposures to light of intensities insufficient to produce thermal damage can still result in retinal damage via nonthermal mechanisms. In this work, the additivity and the repair rate for this actinic damage were measured. Rhesus monkey retinas were exposed to 458 nm light from an argon-ion laser at a dose equivalent to half the threshold retinal irradiance. After prescribed time intervals, the retinal sites were re-exposed to determine the split-dose threshold. This threshold is related to the single-dose threshold through the additivity, which in turn is dependent on the time between exposures. The observed recovery of tissue could be fitted by a single exponential with a time constant of 4 days. This result is incorporated in an analytic expression for the cumulative effect of repeated doses.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×