July 1980
Volume 19, Issue 7
Free
Articles  |   July 1980
Antianaphylactic effects of dipivalyl epinephrine and related compounds in rat conjunctiva.
Investigative Ophthalmology & Visual Science July 1980, Vol.19, 824-826. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      T Iso, K Uda, H Yamauchi, N Nakajima, H Suda; Antianaphylactic effects of dipivalyl epinephrine and related compounds in rat conjunctiva.. Invest. Ophthalmol. Vis. Sci. 1980;19(7):824-826.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Topically applied dipivalyl epinephrine (DPE) and related compounds have been found to inhibit passive anaphylactic reaction in rat conjunctiva. The order of activity is as follows: isoproterenol greater than DPE greater than epinephrine greater than norepinephrine. The antianaphylactic effect of DPE was antagonized by propranolol but was not affected by phentolamine. The effects of epinephrine, norepinephrine, and isoproterenol were also antagonized by propranolol but potentiated by pentolamine. From these findings, it was suggested that DPE not only exerts its antianaphylactic action through activation of beta-adrenergic receptor but also itself has a little different action from epinephrine.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×