July 1981
Volume 21, Issue 1
Articles  |   July 1981
Lymphocyte-induced corneal neovascularization: a morphologic assessment.
Investigative Ophthalmology & Visual Science July 1981, Vol.21, 87-94. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R J Epstein, W F Hughes; Lymphocyte-induced corneal neovascularization: a morphologic assessment.. Invest. Ophthalmol. Vis. Sci. 1981;21(1):87-94.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

Lymphocytes obtained from mesenteric lymph nodes of rabbits were stimulated in vitro by concanavalin A and injected into the corneas of allogeneic hosts. Controls were nonstimulated, killed, or autogeneic lymphocytes injected into the contralateral corneas. The stimulated cells were significantly better inducers of neovascular growth. Histologic observations of the vascularized corneas showing marked mononuclear reactions at the limbus, coupled with the requirement of allogenicity, suggest that there was immunologic recognition of the implanted cells. Stimulated allogeneic blast cells may amplify this host recognition by their elaboration of lymphokines or enhanced antigenicity. The apparent importance of allogenicity for the induction of vessel growth in these experiments may be significant in the pathogenesis tumor-induced or graft-related corneal neovascularization.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.