July 1981
Volume 21, Issue 1
Articles  |   July 1981
Immunohistochemical comparison of ocular zonules and the microfibrils of elastic tissue.
Investigative Ophthalmology & Visual Science July 1981, Vol.21, 130-135. doi:https://doi.org/
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      B W Streeten, P A Licari, A A Marucci, R M Dougherty; Immunohistochemical comparison of ocular zonules and the microfibrils of elastic tissue.. Invest. Ophthalmol. Vis. Sci. 1981;21(1):130-135. doi: https://doi.org/.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements
This content is PDF only. Please click on the PDF icon to access.

Antibody to bovine zonules raised in rabbits gave diffuse staining of zonular fibrils with prominent accumulations at 35 to 45 nm sites of overbanding by means of the indirect immunoperoxidase technique. Antibody binding occurred in both fresh and paraffin-embedded material and was not species specific. The same pattern of heavy antibody binding and 35 to 45 nm periodicity was found on the microfibrils of elastic tissue in human and bovine ciliary body, calf ligamentum nuchae, and chick aorta. This cross reaction is the first direct evidence of a structural similarity or identity between components of the zonules and the microfibrils of elastic tissue, correlating with similarities in their morphology and amino acid profiles. Interstitial collagen fibers appear to have a minimal quantity of antigenically similar material at cross-banding sites. These relationships may hold important clues to the site of systemic involvement in connective tissue diseases associated with lens dislocation. Zonular antibody should prove useful in investigating abnormalities of the zonular-elastic microfibrillar system and cross-banding sites.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.