Purchase this article with an account.
R W Bellhorn, D A Lipman, J Confino, M S Burns; Effect of monosodium glutamate on retinal vessel development and permeability in rats.. Invest. Ophthalmol. Vis. Sci. 1981;21(2):237-247. doi: https://doi.org/.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Monosodium glutamate (MSG) administered to neonatal rats on postnatal days 1 to 10 caused a generalized degeneration of the inner retinal layers. MSG administered only on postnatal days 8, 9, 10, and/or 11 caused a retinopathy limited to more peripheral retinal areas corresponding to currently existing regions of immature retinal vessels. Ink-injected retinal vessel studies showed a delay in development of the retinal vessel network but no alterations in vessel patency. Fluorescence microscopic examination of freeze-dried tissues revealed to abnormalities of the blood-retinal barriers to sodium fluorescein. We conclude, as demonstrated by these methods, that MSG retards development of the retinal vessels but does not affect development of the blood-retinal barriers. The retinotoxic effect of MSG apparently results from a mechanism(s) other than a breakdown of the blood-retinal barrier.
This PDF is available to Subscribers Only