August 1981
Volume 21, Issue 2
Articles  |   August 1981
Retinal degeneration in cats fed casein. IV. The early receptor potential.
Investigative Ophthalmology & Visual Science August 1981, Vol.21, 345-350. doi:
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      E L Berson, G Watson, K L Grasse, R B Szamier; Retinal degeneration in cats fed casein. IV. The early receptor potential.. Invest. Ophthalmol. Vis. Sci. 1981;21(2):345-350.

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      © ARVO (1962-2015); The Authors (2016-present)

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Electroretinographic studies of casein-fed cats with retinal taurine deficiency revealed that the early receptor potential (ERP) was initially normal in amplitude at a time when the a-wave and b-wave of the electroretinogram were substantially reduced or even nondetectable. The preserved ERP's in these taurine-deficient cats could be correlated with the histologic finding that their outer segments were relatively intact over 90% of the retinal area subtended by the test flash. The sequence of electroretinographic changes in these taurine-deficient cats was also consistent with previous biochemical studies on the normal cat retina that have shown a relatively low concentration of taurine at the level of the outer segments and a higher concentration at the level of the inner segments. The responses in early stages from taurine-deficient cats differed from the responses obtained from vitamin A--deficient cats but resembled those from cats that received an intravitreal injection of ouabain. Similarities and a difference between the responses of taurine-deficient cats and those of patients with early retinitis pigmentosa are considered.


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