February 1982
Volume 22, Issue 2
Articles  |   February 1982
HLA-B27, Klebsiella pneumoniae, and the relation to acute anterior uveitis.
Investigative Ophthalmology & Visual Science February 1982, Vol.22, 213-219. doi:https://doi.org/
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      E J Holland, A B Loren, M J O'Donnell, D J Spence, H H Tessler, M M Yokoyama; HLA-B27, Klebsiella pneumoniae, and the relation to acute anterior uveitis.. Invest. Ophthalmol. Vis. Sci. 1982;22(2):213-219. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Acute anterior uveitis (AAU) is a disease of unknown etiology, although it is frequently associated with various autoimmune diseases. It has recently been shown in patients with ankylosing spondylitis (AS), a disease often associated with AAU, that antiserum raised against a particular isolate of Klebsiella pneumoniae would cross-react with lymphocytes possessing HLA-B27. The present study was performed to evaluate the response of lymphocytes of patients to K. pneumoniae and to determine the correlation with HLA-B27. The circulating immune complex levels in the serum of the patients were also determined for correlation with the presence of HLA-B27 antigen. We were able to demonstrate this cross-reactivity in the samples of AAU patients; however, we did find an increased immune complex level that was independent of HLA-B27 antigen. From our results, we conclude that although AAU is clinically associated with AS, the role of K. pneumoniae in these disease states remains unclear.


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